Unexpected guests in the tumor microenvironment: microbiome in cancer

Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has reveale d that the local microbiota make up an important part o...

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Veröffentlicht in:Protein & cell Jg. 12; H. 5; S. 426 - 435
Hauptverfasser: Wong-Rolle, Abigail, Wei, Haohan Karen, Zhao, Chen, Jin, Chengcheng
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Beijing Higher Education Press 01.05.2021
Springer Nature B.V
Schlagworte:
Bacteria - metabolism
Biochemistry
Biomedical and Life Sciences
Cancer
cancer immunotherapy
Cell Biology
Developmental Biology
Gastrointestinal Microbiome
Gastrointestinal tract
Human Genetics
Humans
immune system
Intestine
Life Sciences
Lung cancer
microbiome
Microbiomes
Microbiota
Mucosa
Neoplasms - metabolism
Neoplasms - microbiology
Protein Science
Review
Stem Cells
tumor
Tumor Microenvironment
tumor-associated microbiota
Tumors
lung cancer
tumor-associated microbiota
immune system
microbiome
tumor
cancer immunotherapy
ISSN:1674-800X, 1674-8018, 1674-8018
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has reveale d that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment.
Bibliographie:lung cancer
tumor-associated microbiota
Document received on :2020-08-23
tumor
cancer immunotherapy
immune system
Document accepted on :2020-11-01
microbiome
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ISSN:1674-800X
1674-8018
1674-8018
DOI:10.1007/s13238-020-00813-8