Unexpected guests in the tumor microenvironment: microbiome in cancer

Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has reveale d that the local microbiota make up an important part o...

Full description

Saved in:

Bibliographic Details
Published in:	Protein & cell Vol. 12; no. 5; pp. 426 - 435
Main Authors:	Wong-Rolle, Abigail, Wei, Haohan Karen, Zhao, Chen, Jin, Chengcheng
Format:	Journal Article
Language:	English
Published:	Beijing Higher Education Press 01.05.2021 Springer Nature B.V
Subjects:	Bacteria - metabolism Biochemistry Biomedical and Life Sciences Cancer cancer immunotherapy Cell Biology Developmental Biology Gastrointestinal Microbiome Gastrointestinal tract Human Genetics Humans immune system Intestine Life Sciences Lung cancer microbiome Microbiomes Microbiota Mucosa Neoplasms - metabolism Neoplasms - microbiology Protein Science Review Stem Cells tumor Tumor Microenvironment tumor-associated microbiota Tumors lung cancer tumor-associated microbiota immune system microbiome tumor cancer immunotherapy
ISSN:	1674-800X, 1674-8018, 1674-8018
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has reveale d that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment.
AbstractList	Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has revealed that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment. Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has revealed that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment.Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has revealed that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment. Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has reveale d that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment.
Author	Wei, Haohan Karen Zhao, Chen Jin, Chengcheng Wong-Rolle, Abigail
Author_xml	– sequence: 1 givenname: Abigail surname: Wong-Rolle fullname: Wong-Rolle, Abigail organization: Thoracic and Gastrointestinal Malignancies Branch, National Cancer Institute, National Institutes of Health, 4 Memorial Drive, Bethesda, MD 20892, USA – sequence: 2 givenname: Haohan Karen surname: Wei fullname: Wei, Haohan Karen organization: Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd., Philadelphia, PA 19104, USA – sequence: 3 givenname: Chen surname: Zhao fullname: Zhao, Chen email: chen.zhao@nih.gov (C. Zhao) organization: Thoracic and Gastrointestinal Malignancies Branch, National Cancer Institute, National Institutes of Health, 4 Memorial Drive, Bethesda, MD 20892, USA – sequence: 4 givenname: Chengcheng surname: Jin fullname: Jin, Chengcheng email: Chengcheng.Jin@Pennmedicine.upenn.edu (C. Jin) organization: Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd., Philadelphia, PA 19104, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33296049$$D View this record in MEDLINE/PubMed
BookMark	eNp9kc1u1TAUhC1UREvpC7BAkdiwCRz_JQ4LpKoqUKlSN63EznKck3tdJfbFTip4exzSFtrF9caWPd9ofOY1OfDBIyFvKXykAPWnRDnjqgQGJYCivFQvyBGtalEqoOrg8Qw_DslJSreQF-dUVvUrcsg5ayoQzRE5v_H4a4d2wq7YzJimVDhfTFsspnkMsRidjQH9nYvBj-inz-tN68KIi9IabzG-IS97MyQ8ud-PyfXX8-uz7-Xl1beLs9PL0komppJ3rG-lQTTQcOyZqEEoJTpuGLctCmugpy3IvhKcGitry1poGBrLbKNafky-rLa7uR2xszlPNIPeRTea-FsH4_TTF--2ehPutKJQSSmywYd7gxh-Lr_Vo0sWh8F4DHPSTFSqknmaPEvfP5Pehjn6_DvNJOMN5UItqnf_J3qM8jDgLFCrIA8tpYi9tm4ykwtLQDdoCnqpU6916lyn_lunVhllz9AH970QX6GUxX6D8V_svVSzUlu32WLEbhcxJd3n0ieHcS_7B2IFxPk
CitedBy_id	crossref_primary_10_1002_bab_2738 crossref_primary_10_1080_1040841X_2022_2080526 crossref_primary_10_3390_antibiotics11111521 crossref_primary_10_1159_000541678 crossref_primary_10_1007_s44337_024_00063_1 crossref_primary_10_1186_s40779_025_00623_1 crossref_primary_10_1002_advs_202403393 crossref_primary_10_1111_andr_13305 crossref_primary_10_1007_s12672_025_02038_9 crossref_primary_10_1080_19490976_2022_2073785 crossref_primary_10_1016_j_isci_2024_109893 crossref_primary_10_1002_VIW_20230100 crossref_primary_10_1016_j_heliyon_2024_e32273 crossref_primary_10_3390_ijms25179463 crossref_primary_10_1007_s12272_025_01532_6 crossref_primary_10_1007_s13577_021_00659_0 crossref_primary_10_3389_fphar_2025_1627656 crossref_primary_10_1186_s12967_024_05320_6 crossref_primary_10_3390_cells12242801 crossref_primary_10_1007_s12672_023_00745_9 crossref_primary_10_1039_D5BM00026B crossref_primary_10_1038_s41598_024_72918_7 crossref_primary_10_1038_s41598_025_87194_2 crossref_primary_10_1016_j_addr_2024_115345 crossref_primary_10_1002_EXP_20210185 crossref_primary_10_3389_fonc_2023_1154586 crossref_primary_10_1016_j_bbcan_2021_188626 crossref_primary_10_1016_j_intimp_2024_112984 crossref_primary_10_3390_pathogens14010002 crossref_primary_10_1016_j_biopha_2023_115336 crossref_primary_10_1038_s41392_023_01406_7 crossref_primary_10_1016_j_canlet_2022_216031 crossref_primary_10_1111_jop_13298 crossref_primary_10_1038_s41598_025_16431_5 crossref_primary_10_1007_s12672_025_02595_z crossref_primary_10_1016_j_phrs_2025_107897 crossref_primary_10_1007_s12672_025_03379_1 crossref_primary_10_1136_jitc_2022_004698 crossref_primary_10_1016_j_ecoenv_2024_116821 crossref_primary_10_1186_s12943_025_02328_4 crossref_primary_10_3389_fgene_2022_957675 crossref_primary_10_3892_or_2024_8803 crossref_primary_10_3389_fonc_2025_1506577 crossref_primary_10_1038_s41522_025_00789_5 crossref_primary_10_3389_fimmu_2022_1008975 crossref_primary_10_3389_fimmu_2024_1375433 crossref_primary_10_1128_msystems_00457_24 crossref_primary_10_1002_ijc_70063 crossref_primary_10_3389_fimmu_2024_1507355 crossref_primary_10_1016_j_coi_2025_102537 crossref_primary_10_1016_j_isci_2021_103638 crossref_primary_10_3389_fimmu_2022_1001381 crossref_primary_10_1093_bjsopen_zraf091 crossref_primary_10_3389_fimmu_2022_968729 crossref_primary_10_59717_j_xinn_life_2023_100016 crossref_primary_10_1002_smtd_202301309 crossref_primary_10_1002_cac2_12597 crossref_primary_10_1002_cbf_3999 crossref_primary_10_1016_j_shpsa_2022_12_007 crossref_primary_10_3389_fmicb_2023_1100873 crossref_primary_10_1080_19490976_2024_2369336 crossref_primary_10_3390_ijms241713237 crossref_primary_10_1007_s12094_024_03697_w crossref_primary_10_3390_biology14070756 crossref_primary_10_1142_S0192415X24500903 crossref_primary_10_1080_21505594_2024_2313410 crossref_primary_10_3389_fimmu_2023_1298524 crossref_primary_10_3389_fcimb_2023_1294082 crossref_primary_10_3389_fcell_2025_1480233 crossref_primary_10_1111_1759_7714_14159 crossref_primary_10_59717_j_xinn_life_2023_100028 crossref_primary_10_1002_cac2_12200 crossref_primary_10_1093_pcmedi_pbac005 crossref_primary_10_1128_mbio_03873_24 crossref_primary_10_1177_20499361251333562 crossref_primary_10_3390_ijms251910486 crossref_primary_10_1007_s12072_023_10507_y crossref_primary_10_1016_j_micres_2024_127857 crossref_primary_10_1038_s41598_024_85035_2 crossref_primary_10_3892_or_2023_8618 crossref_primary_10_1016_j_ajoc_2023_101833 crossref_primary_10_1002_mnfr_202400750 crossref_primary_10_2147_IJN_S439381 crossref_primary_10_1016_j_bbcan_2025_189364 crossref_primary_10_1097_HEP_0000000000000427 crossref_primary_10_3389_fmicb_2025_1591735 crossref_primary_10_3892_ol_2025_15273 crossref_primary_10_3389_fmicb_2025_1551515 crossref_primary_10_3748_wjg_v28_i18_1981 crossref_primary_10_1016_j_semcancer_2025_07_005 crossref_primary_10_3390_cancers17132181 crossref_primary_10_1002_advs_202203115 crossref_primary_10_1016_j_biopha_2025_118559 crossref_primary_10_1186_s12879_025_10851_4 crossref_primary_10_1073_pnas_2421710122 crossref_primary_10_7759_cureus_45474 crossref_primary_10_1177_10815589241277829 crossref_primary_10_3390_cancers15030935 crossref_primary_10_1007_s11033_023_08910_7 crossref_primary_10_1016_j_cej_2022_139939 crossref_primary_10_1016_j_ijpx_2025_100400 crossref_primary_10_3389_fnut_2025_1602603 crossref_primary_10_1128_spectrum_01068_22 crossref_primary_10_3389_fimmu_2023_1235827 crossref_primary_10_3389_fcimb_2024_1474998 crossref_primary_10_3390_cancers16193416 crossref_primary_10_1111_1751_7915_70029 crossref_primary_10_1002_ctm2_1331 crossref_primary_10_1016_j_micres_2024_127871 crossref_primary_10_1016_j_pdpdt_2025_104518 crossref_primary_10_1007_s00284_024_04004_0 crossref_primary_10_1016_j_ijrobp_2023_06_2515 crossref_primary_10_1016_j_bpg_2024_101961 crossref_primary_10_1038_s41392_023_01693_0 crossref_primary_10_1186_s12967_025_06142_w crossref_primary_10_3389_fimmu_2022_874922 crossref_primary_10_1016_j_semcancer_2025_09_005 crossref_primary_10_3389_fimmu_2025_1581492 crossref_primary_10_1016_j_micpath_2024_107091 crossref_primary_10_3389_fimmu_2022_935846 crossref_primary_10_1007_s00432_021_03567_w crossref_primary_10_3389_fcimb_2025_1513270 crossref_primary_10_3389_fonc_2024_1451175 crossref_primary_10_1155_2023_3965198 crossref_primary_10_3390_jpm14111083 crossref_primary_10_1016_j_ccr_2025_216938 crossref_primary_10_3390_molecules27010137 crossref_primary_10_1080_03007995_2022_2129231 crossref_primary_10_1016_j_lfs_2022_121215 crossref_primary_10_1038_s43705_023_00338_1 crossref_primary_10_1007_s00284_025_04390_z crossref_primary_10_1093_carcin_bgac063 crossref_primary_10_1158_1541_7786_MCR_24_0747 crossref_primary_10_1155_2024_8640014 crossref_primary_10_3350_cmh_2024_1039 crossref_primary_10_3390_ijms24032170 crossref_primary_10_1155_2022_3387671 crossref_primary_10_1186_s13073_023_01180_9 crossref_primary_10_1016_j_bioactmat_2023_09_007 crossref_primary_10_1038_s41420_024_02258_y crossref_primary_10_1128_spectrum_02830_24 crossref_primary_10_1007_s13402_023_00876_9 crossref_primary_10_1016_j_biomaterials_2024_123078 crossref_primary_10_3390_microorganisms11020288 crossref_primary_10_1186_s13048_024_01464_7 crossref_primary_10_3390_ijms231911566 crossref_primary_10_1097_MD_0000000000038078 crossref_primary_10_1002_agm2_12359 crossref_primary_10_1002_mco2_715 crossref_primary_10_3390_biomedicines13051261 crossref_primary_10_3389_fimmu_2024_1431747 crossref_primary_10_1016_j_gene_2024_148347 crossref_primary_10_3389_fimmu_2022_923533 crossref_primary_10_3389_fonc_2025_1505656 crossref_primary_10_1002_advs_202200470 crossref_primary_10_25259_Cytojournal_43_2024 crossref_primary_10_3390_cancers14215394 crossref_primary_10_3390_cancers15245859 crossref_primary_10_1002_mco2_70018 crossref_primary_10_1016_j_biopha_2021_112443 crossref_primary_10_1016_j_heliyon_2024_e35617 crossref_primary_10_1039_D5PM00045A crossref_primary_10_3389_fphar_2023_1320028 crossref_primary_10_3389_fonc_2023_1198259 crossref_primary_10_1038_s41416_025_03106_1 crossref_primary_10_1007_s12672_025_03378_2 crossref_primary_10_3389_fimmu_2024_1389446 crossref_primary_10_3390_jcm13133885 crossref_primary_10_3389_fonc_2023_1127225 crossref_primary_10_3389_fimmu_2022_1051987 crossref_primary_10_1097_JU9_0000000000000306 crossref_primary_10_1186_s12967_025_06916_2 crossref_primary_10_3390_metabo11110758 crossref_primary_10_1007_s00284_025_04289_9 crossref_primary_10_3389_fgene_2024_1481787 crossref_primary_10_1038_s41598_025_12160_x crossref_primary_10_1099_jmm_0_001744 crossref_primary_10_1016_j_tim_2025_03_011 crossref_primary_10_33073_pjm_2023_044 crossref_primary_10_3389_fimmu_2023_1290414 crossref_primary_10_2147_IJN_S413831 crossref_primary_10_1016_j_gendis_2025_101733 crossref_primary_10_1093_carcin_bgad078 crossref_primary_10_1016_j_intimp_2025_114283 crossref_primary_10_1080_19490976_2024_2341717 crossref_primary_10_3390_ijms26167814 crossref_primary_10_1186_s12964_023_01425_5 crossref_primary_10_1186_s40779_023_00471_x crossref_primary_10_1016_j_critrevonc_2025_104629 crossref_primary_10_3389_fneur_2025_1549465 crossref_primary_10_4103_jcrt_jcrt_50_24 crossref_primary_10_3389_fonc_2022_924849 crossref_primary_10_3390_ijms23115896 crossref_primary_10_3390_cancers15020509 crossref_primary_10_1016_j_micres_2022_127082 crossref_primary_10_1016_j_canlet_2024_217077 crossref_primary_10_3390_ijms26188844 crossref_primary_10_1186_s13027_025_00667_x crossref_primary_10_1016_j_micpath_2024_106784 crossref_primary_10_1515_biol_2022_0850 crossref_primary_10_3389_fimmu_2025_1582166 crossref_primary_10_1002_cam4_70703 crossref_primary_10_1093_pcmedi_pbae020 crossref_primary_10_1128_spectrum_00390_25
Cites_doi	10.1126/science.1224820 10.3389/fmicb.2018.00951 10.1002/ijc.31098 10.1128/CMR.00053-08 10.1186/s13059-016-1021-1 10.1016/j.cell.2019.07.008 10.1126/science.1127059 10.4049/jimmunol.1600279 10.1084/jem.20192282 10.1126/science.aaa4972 10.1186/s13059-018-1501-6 10.1111/1471-0528.15854 10.1183/09031936.01.00228801 10.1038/nature11234 10.1016/j.chom.2013.07.007 10.1038/s41586-019-1608-2 10.1126/science.aah3648 10.1371/journal.pone.0016384 10.1016/j.cell.2006.02.017 10.1038/ncomms6932 10.1007/s00018-020-03452-8 10.1126/science.aar7785 10.1158/1078-0432.CCR-16-1786 10.1038/mi.2016.129 10.1016/j.cell.2014.03.011 10.1146/annurev-immunol-082019-081656 10.3322/caac.21442 10.1126/science.aal5240 10.1126/science.aaw2367 10.1128/IAI.00522-09 10.1038/ni.2604 10.1038/nrc3611 10.1016/S0140-6736(14)61136-3 10.1101/gr.126573.111 10.1016/j.jaad.2013.01.016 10.1126/science.aay9189 10.1016/j.immuni.2017.04.005 10.1093/infdis/155.5.855 10.1016/S1470-2045(12)70137-7 10.1038/nature24462 10.1586/ers.13.24 10.1111/j.1600-065X.2012.01099.x 10.1038/s41598-019-49195-w 10.1126/science.1177486 10.1126/scitranslmed.3000251 10.1126/science.aah5043 10.1126/sciadv.aao4502 10.1128/AEM.01235-16 10.3322/caac.21551 10.1111/j.1742-4658.2011.08125.x 10.1016/j.trecan.2019.12.007 10.1016/j.cell.2017.07.008 10.1016/j.celrep.2018.08.090 10.1053/j.gastro.2014.01.001 10.1016/j.lungcan.2016.10.016 10.1378/chest.91.2.233 10.18632/oncotarget.15687 10.1126/science.1240527 10.1016/j.trecan.2019.10.005 10.1371/journal.pone.0177062 10.1164/rccm.201104-0655OC 10.1016/j.ccell.2020.06.017 10.1126/science.aao3290 10.1158/2159-8290.CD-17-1134 10.1126/science.aad1329 10.1513/AnnalsATS.201501-029OC 10.1016/j.chom.2013.07.012 10.1371/journal.pone.0008578 10.1007/s12223-018-00670-3 10.1101/gr.126516.111 10.1038/srep30751 10.1164/rccm.201710-2118OC 10.1126/science.aan4236 10.1016/j.immuni.2015.01.010 10.1126/science.aan3706 10.1038/mi.2016.108 10.1146/annurev-immunol-051116-052133 10.1126/science.aac4255 10.1126/science.1240537 10.1038/s41586-020-2541-0
ContentType	Journal Article
Copyright	Copyright reserved, 2020, The Author(s) The Author(s) 2020 The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: Copyright reserved, 2020, The Author(s) – notice: The Author(s) 2020 – notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 5PM
DOI	10.1007/s13238-020-00813-8
DatabaseName	SpringerOpen CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest : Biological Science Collection journals [unlimited simultaneous users] ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database ProQuest Central Premium ProQuest One Academic ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	CrossRef Publicly Available Content Database MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	1674-8018
EndPage	435
ExternalDocumentID	PMC8106554 33296049 10_1007_s13238_020_00813_8 10.1007/s13238-020-00813-8
Genre	Research Support, N.I.H., Intramural Review Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NCI NIH HHS grantid: K99 CA226400 – fundername: NCI NIH HHS grantid: R00 CA226400
GroupedDBID	--- -A0 0R~ 0VY 1-T 1N0 2JY 2VQ 30V 3V. 408 409 40D 53G 5VS 67N 7X7 88E 8AO 8FE 8FH 8FI 8FJ AAFWJ AAKKN AAPXW AAVAP AAYZJ ABPTD ABUWG ABXVV ACACY ACGFS ACPRK ACULB ADBBV ADINQ AENEX AFGXO AFKRA AFNRJ AFPKN AFWTZ AGJBK AHBXF AHBYD AHMBA AHSBF AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AOIJS BAPOH BAWUL BBNVY BCNDV BENPR BGNMA BHPHI BPHCQ BVXVI C24 C6C CAG CCPQU COF DIK EBD EBS EMOBN F5P FYUFA GQ8 GROUPED_DOAJ HCIFZ HMCUK HMJXF HYE HZ~ I0C IPNFZ IZIGR KOV KQ8 LK8 M1P M4Y M7P NU0 O9- OJZSN OK1 P4S PIMPY PQQKQ PROAC PSQYO QOS R9I RIG ROX RPM RSV S27 S3A S3B SBL SCL SOJ SV3 T13 TOX TUS U2A UKHRP WK8 ~A9 AAYZH ABEEZ ABEJV ABGNP ALIPV AMNDL H13 -SA -S~ AAXDM AAYXX ABFSG ACSTC AEZWR AFFHD AFHIU AHWEU AIXLP CAJEA CITATION PHGZM PHGZT PJZUB PPXIY PQGLB Q-- TGP U1G U5K CGR CUY CVF ECM EIF NPM 7XB 8FK AZQEC DWQXO GNUQQ K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c524t-3d2fb5aeea093ef24704884d3a23cbe4ca0f1b05f6431ac57c2b092eac2c98b3
IEDL.DBID	M7P
ISICitedReferencesCount	232
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000597722700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1674-800X 1674-8018
IngestDate	Tue Nov 04 01:51:50 EST 2025 Fri Sep 05 06:22:18 EDT 2025 Sat Nov 29 14:22:29 EST 2025 Wed Feb 19 02:27:13 EST 2025 Tue Nov 18 22:37:08 EST 2025 Sat Nov 29 04:39:41 EST 2025 Fri Feb 21 02:48:31 EST 2025 Tue Feb 27 04:43:01 EST 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	5
Keywords	lung cancer tumor-associated microbiota immune system microbiome tumor cancer immunotherapy
Language	English
License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c524t-3d2fb5aeea093ef24704884d3a23cbe4ca0f1b05f6431ac57c2b092eac2c98b3
Notes	lung cancer tumor-associated microbiota Document received on :2020-08-23 tumor cancer immunotherapy immune system Document accepted on :2020-11-01 microbiome ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
OpenAccessLink	https://www.proquest.com/docview/2523913483?pq-origsite=%requestingapplication%
PMID	33296049
PQID	2523913483
PQPubID	2034672
PageCount	10
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_8106554 proquest_miscellaneous_2468658133 proquest_journals_2523913483 pubmed_primary_33296049 crossref_citationtrail_10_1007_s13238_020_00813_8 crossref_primary_10_1007_s13238_020_00813_8 springer_journals_10_1007_s13238_020_00813_8 higheredpress_frontiers_10_1007_s13238_020_00813_8
PublicationCentury	2000
PublicationDate	2021-05-01
PublicationDateYYYYMMDD	2021-05-01
PublicationDate_xml	– month: 05 year: 2021 text: 2021-05-01 day: 01
PublicationDecade	2020
PublicationPlace	Beijing
PublicationPlace_xml	– name: Beijing – name: Germany – name: Heidelberg
PublicationTitle	Protein & cell
PublicationTitleAbbrev	Protein Cell
PublicationTitleAlternate	Protein Cell
PublicationYear	2021
Publisher	Higher Education Press Springer Nature B.V
Publisher_xml	– name: Higher Education Press – name: Springer Nature B.V
References	Vitiello, Cohen, Miller (CR77) 2019; 5 de Martel, Ferlay, Franceschi, Vignat, Bray, Forman, Plummer (CR15) 2012; 13 Putze, Hennequin, Nougayrede, Zhang, Homburg, Karch, Bringer, Fayolle, Carniel, Rabsch (CR58) 2009; 77 Castellarin, Warren, Freeman, Dreolini, Krzywinski, Strauss, Barnes, Watson, Allen-Vercoe, Moore (CR11) 2012; 22 Gur, Ibrahim, Isaacson, Yamin, Abed, Gamliel, Enk, Bar-On, Stanietsky-Kaynan, Coppenhagen-Glazer (CR32) 2015; 42 Mrázek, Mekadim, Kučerová, Švejstil, Salmonová, Vlasáková, Tarasová, Čížková, Červinková (CR50) 2019; 64 Jin, Lagoudas, Zhao, Bullman, Bhutkar, Hu, Ameh, Sandel, Liang, Mazzilli (CR40) 2019; 176 Yan, Yang, Liu, Gao, Hu, Li, Zhang, Shi, Guo, Cheng (CR80) 2015; 5 Kadosh, Snir-Alkalay, Venkatachalam, May, Lasry, Elyada, Zinger, Shaham, Vaalani, Mernberger (CR41) 2020; 586 Wilson, Jiang, Villalta, Stornetta, Boudreau, Carrá, Brennan, Chun, Ngo, Samson (CR78) 2019; 363 Kostic, Chun, Robertson, Glickman, Gallini, Michaud, Clancy, Chung, Lochhead, Hold (CR42) 2013; 14 Ley, Peterson, Gordon (CR46) 2006; 124 Belkaid, Naik (CR8) 2013; 14 (CR38) 2012; 486 Nakatsuji, Chen, Butcher, Trzoss, Nam, Shirakawa, Zhou, Oh, Otto, Fenical (CR51) 2018; 4 Sommariva, Le Noci, Bianchi, Camelliti, Balsari, Tagliabue, Sfondrini (CR71) 2020; 77 Urbaniak, Gloor, Brackstone, Scott, Tangney, Reid (CR74) 2016; 82 Greathouse, White, Vargas, Bliskovsky, Beck, von Muhlinen, Polley, Bowman, Khan, Robles (CR30) 2018; 19 Banerjee, Tian, Wei, Shih, Feldman, Peck, DeMichele, Alwine, Robertson (CR5) 2018; 9 Guerra, Guidi, Frisan (CR31) 2011; 278 Garrett (CR25) 2019; 364 Yu, Guo, Yu, Sun, Ma, Han, Qian, Kryczek, Sun, Nagarsheth (CR82) 2017; 170 Pilette, Ouadrhiri, Godding, Vaerman, Sibille (CR56) 2001; 18 Shannon, Yi, Perusini, Gajer, Ma, Humphrys, Thomas-Pavanel, Chieza, Janakiram, Saunders (CR66) 2017; 10 Abreu, Peek (CR1) 2014; 146 Huffnagle, Dickson, Lukacs (CR37) 2017; 10 Hoste, Arwert, Lal, South, Salas-Alanis, Murrell, Donati, Watt (CR36) 2015; 6 Belkaid, Hand (CR7) 2014; 157 Dickson, Martinez, Huffnagle (CR19) 2014; 384 Greathouse, Stone, Harris (CR29) 2020; 38 Bullman, Pedamallu, Sicinska, Clancy, Zhang, Cai, Neuberg, Huang, Guevara, Nelson (CR9) 2017; 358 O’Dwyer, Dickson, Moore (CR55) 2016; 196 Riquelme, Zhang, Zhang, Montiel, Zoltan, Dong, Quesada, Sahin, Chandra, San Lucas (CR60) 2019; 178 Balachandran, Łuksza, Zhao, Makarov, Moral, Remark, Herbst, Askan, Bhanot, Senbabaoglu (CR4) 2017; 551 Shalapour, Karin (CR64) 2020; 38 Matson, Fessler, Bao, Chongsuwat, Zha, Alegre, Luke, Gajewski (CR49) 2018; 359 Sears (CR63) 2009; 22 Le Noci, Guglielmetti, Arioli, Camisaschi, Bianchi, Sommariva, Storti, Triulzi, Castelli, Balsari (CR44) 2018; 24 Garrett (CR24) 2015; 348 Shang, Hua, Hu (CR65) 2017; 8 Siegel, Miller, Jemal (CR68) 2018; 68 Yamamura, Baba, Nakagawa, Mima, Miyake, Nakamura, Sawayama, Kinoshita, Ishimoto, Iwatsuki (CR79) 2016; 22 Vétizou, Pitt, Daillère, Lepage, Waldschmitt, Flament, Rusakiewicz, Routy, Roberti, Duong (CR75) 2015; 350 DiDonato, Mercurio, Karin (CR20) 2012; 246 Rubinstein, Wang, Liu, Hao, Cai, Han (CR62) 2013; 14 Costello, Lauber, Hamady, Fierer, Gordon, Knight (CR14) 2009; 326 Sivan, Corrales, Hubert, Williams, Aquino-Michaels, Earley, Benyamin, Lei, Jabri, Alegre (CR70) 2015; 350 Iida, Dzutsev, Stewart, Smith, Bouladoux, Weingarten, Molina, Salcedo, Back, Cramer (CR39) 2013; 342 Gomes, Cavadas, Ferreira, Marques, Monteiro, Sucena, Sousa, Vaz Rodrigues, Teixeira, Pinto (CR27) 2019; 9 Liu, Tao, Zhang, Zhu, Zheng, Liu, Zhou, Ke, Shi, Qu (CR47) 2018; 142 Lee, Sung, Yong, Chun, Kim, Song, Chung, Kim, Jung, Kang (CR45) 2016; 102 Shi, Zheng, Yang, Harris, Ni, Xue, Lin, Chang, Weichselbaum, Fu (CR67) 2020; 217 Gopalakrishnan, Spencer, Nezi, Reuben, Andrews, Karpinets, Prieto, Vicente, Hoffman, Wei (CR28) 2018; 359 Norenhag, Du, Olovsson, Verstraelen, Engstrand, Brusselaers (CR53) 2020; 127 Thorpe, Baughman, Frame, Wesseler, Staneck (CR72) 1987; 155 Viaud, Saccheri, Mignot, Yamazaki, Daillere, Hannani, Enot, Pfirschke, Engblom, Pittet (CR76) 2013; 342 Lloyd, Marsland (CR48) 2017; 46 Elinav, Nowarski, Thaiss, Hu, Jin, Flavell (CR22) 2013; 13 Kostic, Gevers, Pedamallu, Michaud, Duke, Earl, Ojesina, Jung, Bass, Tabernero (CR43) 2012; 22 Dickson, Erb-Downward, Freeman, McCloskey, Beck, Huffnagle, Curtis (CR17) 2015; 12 Yu, Gail, Consonni, Carugno, Humphrys, Pesatori, Caporaso, Goedert, Ravel, Landi (CR81) 2016; 17 Hilty, Burke, Pedro, Cardenas, Bush, Bossley, Davies, Ervine, Poulter, Pachter (CR35) 2010; 5 Arthur, Perez-Chanona, Muhlbauer, Tomkovich, Uronis, Fan, Campbell, Abujamel, Dogan, Rogers (CR2) 2012; 338 Baughman, Thorpe, Staneck, Rashkin, Frame (CR6) 1987; 91 Routy, Le Chatelier, Derosa, Duong, Alou, Daillere, Fluckiger, Messaoudene, Rauber, Roberti (CR61) 2018; 359 Gustafson, Soldi, Anderlind, Scholand, Qian, Zhang, Cooper, Walker, McWilliams, Liu (CR33) 2010; 2 Aykut, Pushalkar, Chen, Li, Abengozar, Kim, Shadaloey, Wu, Preiss, Verma (CR3) 2019; 574 Charlson, Bittinger, Haas, Fitzgerald, Frank, Yadav, Bushman, Collman (CR12) 2011; 184 Nejman, Livyatan, Fuks, Gavert, Zwang, Geller, Rotter-Maskowitz, Weiser, Mallel, Gigi (CR52) 2020; 368 Nougayrede, Homburg, Taieb, Boury, Brzuszkiewicz, Gottschalk, Buchrieser, Hacker, Dobrindt, Oswald (CR54) 2006; 313 Pushalkar, Hundeyin, Daley, Zambirinis, Kurz, Mishra, Mohan, Aykut, Usyk, Torres (CR57) 2018; 8 Ramirez-Labrada, Isla, Artal, Arias, Rezusta, Pardo, Galvez (CR59) 2020; 6 Siegel, Miller, Jemal (CR69) 2019; 69 Dejea, Fathi, Craig, Boleij, Taddese, Geis, Wu, DeStefano Shields, Hechenbleikner, Huso (CR16) 2018; 359 Hieken, Chen, Hoskin, Walther-Antonio, Johnson, Ramaker, Xiao, Radisky, Knutson, Kalari (CR34) 2016; 6 Tsay, Wu, Badri, Clemente, Shen, Meyn, Li, Yie, Lhakhang, Olsen (CR73) 2018; 198 Dzutsev, Badger, Perez-Chanona, Roy, Salcedo, Smith, Trinchieri (CR21) 2017; 35 Cameron, Lewis, Huws, Hegarty, Lewis, Pachebat, Mur (CR10) 2017; 12 Chen, Tsao (CR13) 2013; 69 Dickson, Erb-Downward, Huffnagle (CR18) 2013; 7 Geller, Barzily-Rokni, Danino, Jonas, Shental, Nejman, Gavert, Zwang, Cooper, Shee (CR26) 2017; 357 Erb-Downward, Thompson, Han, Freeman, McCloskey, Schmidt, Young, Toews, Curtis, Sundaram (CR23) 2011; 6 J Putze (813_CR58) 2009; 77 AM Gustafson (813_CR33) 2010; 2 GB Huffnagle (813_CR37) 2017; 10 AG Ramirez-Labrada (813_CR59) 2020; 6 RP Dickson (813_CR18) 2013; 7 M Vétizou (813_CR75) 2015; 350 RL Siegel (813_CR68) 2018; 68 M Hilty (813_CR35) 2010; 5 G Yu (813_CR81) 2016; 17 JA DiDonato (813_CR20) 2012; 246 RE Ley (813_CR46) 2006; 124 WS Garrett (813_CR24) 2015; 348 C Gur (813_CR32) 2015; 42 A Dzutsev (813_CR21) 2017; 35 JP Nougayrede (813_CR54) 2006; 313 SH Lee (813_CR45) 2016; 102 Y Belkaid (813_CR8) 2013; 14 MR Wilson (813_CR78) 2019; 363 M Castellarin (813_CR11) 2012; 22 L Guerra (813_CR31) 2011; 278 Y Shi (813_CR67) 2020; 217 N Iida (813_CR39) 2013; 342 E Kadosh (813_CR41) 2020; 586 AD Kostic (813_CR42) 2013; 14 JC Arthur (813_CR2) 2012; 338 CM Lloyd (813_CR48) 2017; 46 C Pilette (813_CR56) 2001; 18 E Hoste (813_CR36) 2015; 6 DN O’Dwyer (813_CR55) 2016; 196 JJ Tsay (813_CR73) 2018; 198 S Shalapour (813_CR64) 2020; 38 S Banerjee (813_CR5) 2018; 9 C de Martel (813_CR15) 2012; 13 KL Greathouse (813_CR30) 2018; 19 MT Abreu (813_CR1) 2014; 146 K Yamamura (813_CR79) 2016; 22 AD Kostic (813_CR43) 2012; 22 D Nejman (813_CR52) 2020; 368 CM Dejea (813_CR16) 2018; 359 Y Belkaid (813_CR7) 2014; 157 LT Geller (813_CR26) 2017; 357 VP Balachandran (813_CR4) 2017; 551 RL Siegel (813_CR69) 2019; 69 RP Dickson (813_CR19) 2014; 384 B Shannon (813_CR66) 2017; 10 V Gopalakrishnan (813_CR28) 2018; 359 S Gomes (813_CR27) 2019; 9 E Elinav (813_CR22) 2013; 13 JR Erb-Downward (813_CR23) 2011; 6 HX Liu (813_CR47) 2018; 142 E Riquelme (813_CR60) 2019; 178 B Routy (813_CR61) 2018; 359 RP Baughman (813_CR6) 1987; 91 B Aykut (813_CR3) 2019; 574 SJS Cameron (813_CR10) 2017; 12 T Yu (813_CR82) 2017; 170 S Shang (813_CR65) 2017; 8 KL Greathouse (813_CR29) 2020; 38 JE Thorpe (813_CR72) 1987; 155 TJ Hieken (813_CR34) 2016; 6 A Sivan (813_CR70) 2015; 350 Human Microbiome Project Consortium (813_CR38) 2012; 486 WS Garrett (813_CR25) 2019; 364 CL Sears (813_CR63) 2009; 22 S Viaud (813_CR76) 2013; 342 C Urbaniak (813_CR74) 2016; 82 X Yan (813_CR80) 2015; 5 T Nakatsuji (813_CR51) 2018; 4 MR Rubinstein (813_CR62) 2013; 14 GA Vitiello (813_CR77) 2019; 5 EK Costello (813_CR14) 2009; 326 RP Dickson (813_CR17) 2015; 12 C Jin (813_CR40) 2019; 176 V Matson (813_CR49) 2018; 359 S Bullman (813_CR9) 2017; 358 J Mrázek (813_CR50) 2019; 64 YE Chen (813_CR13) 2013; 69 J Norenhag (813_CR53) 2020; 127 ES Charlson (813_CR12) 2011; 184 V Le Noci (813_CR44) 2018; 24 M Sommariva (813_CR71) 2020; 77 S Pushalkar (813_CR57) 2018; 8
References_xml	– volume: 359 start-page: 592 year: 2018 end-page: 597 ident: CR16 article-title: Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria publication-title: Science – volume: 124 start-page: 837 year: 2006 end-page: 848 ident: CR46 article-title: Ecological and evolutionary forces shaping microbial diversity in the human intestine publication-title: Cell – volume: 9 start-page: 12838 year: 2019 ident: CR27 article-title: Profiling of lung microbiota discloses differences in adenocarcinoma and squamous cell carcinoma publication-title: Sci Rep – volume: 313 start-page: 848 year: 2006 end-page: 851 ident: CR54 article-title: induces DNA double-strand breaks in eukaryotic cells publication-title: Science – volume: 68 start-page: 7 year: 2018 end-page: 30 ident: CR68 article-title: Cancer statistics, 2018 publication-title: CA Cancer J Clin – volume: 12 start-page: e0177062 year: 2017 ident: CR10 article-title: A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer publication-title: PLoS ONE – volume: 5 start-page: 670 year: 2019 end-page: 676 ident: CR77 article-title: Harnessing the microbiome for pancreatic cancer immunotherapy publication-title: Trends Cancer – volume: 38 start-page: 158 year: 2020 end-page: 160 ident: CR29 article-title: Cancer-type-specific bacteria: freeloaders or partners? publication-title: Cancer Cell – volume: 8 start-page: 33972 year: 2017 end-page: 33989 ident: CR65 article-title: The regulation of β-catenin activity and function in cancer: therapeutic opportunities publication-title: OncoTarget – volume: 338 start-page: 120 year: 2012 end-page: 123 ident: CR2 article-title: Intestinal inflammation targets cancer-inducing activity of the microbiota publication-title: Science – volume: 278 start-page: 4577 year: 2011 end-page: 4588 ident: CR31 article-title: Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression? publication-title: FEBS J – volume: 363 start-page: eaar7785 year: 2019 ident: CR78 article-title: The human gut bacterial genotoxin colibactin alkylates DNA publication-title: Science – volume: 12 start-page: 821 year: 2015 end-page: 830 ident: CR17 article-title: Spatial variation in the healthy human lung microbiome and the adapted island model of lung biogeography publication-title: Ann Am Thorac Soc – volume: 14 start-page: 646 year: 2013 end-page: 653 ident: CR8 article-title: Compartmentalized and systemic control of tissue immunity by commensals publication-title: Nat Immunol – volume: 348 start-page: 80 year: 2015 end-page: 86 ident: CR24 article-title: Cancer and the microbiota publication-title: Science – volume: 155 start-page: 855 year: 1987 end-page: 861 ident: CR72 article-title: Bronchoalveolar lavage for diagnosing acute bacterial pneumonia publication-title: J Infect Dis – volume: 10 start-page: 1310 year: 2017 end-page: 1319 ident: CR66 article-title: Association of HPV infection and clearance with cervicovaginal immunology and the vaginal microbiota publication-title: Mucosal Immunol – volume: 13 start-page: 607 year: 2012 end-page: 615 ident: CR15 article-title: Global burden of cancers attributable to infections in 2008: a review and synthetic analysis publication-title: Lancet Oncol – volume: 5 start-page: 3111 year: 2015 end-page: 3122 ident: CR80 article-title: Discovery and validation of potential bacterial biomarkers for lung cancer publication-title: Am J Cancer Res – volume: 8 start-page: 403 year: 2018 end-page: 416 ident: CR57 article-title: The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression publication-title: Cancer Discov – volume: 357 start-page: 1156 year: 2017 end-page: 1160 ident: CR26 article-title: Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine publication-title: Science – volume: 22 start-page: 299 year: 2012 end-page: 306 ident: CR11 article-title: infection is prevalent in human colorectal carcinoma publication-title: Genome Res – volume: 350 start-page: 1079 year: 2015 end-page: 1084 ident: CR75 article-title: Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota publication-title: Science – volume: 178 start-page: 795 year: 2019 end-page: 806.e712 ident: CR60 article-title: Tumor microbiome diversity and composition influence pancreatic cancer outcomes publication-title: Cell – volume: 2 start-page: 26ra25 year: 2010 ident: CR33 article-title: Airway PI3K pathway activation is an early and reversible event in lung cancer development publication-title: Sci Transl Med – volume: 127 start-page: 171 year: 2020 end-page: 180 ident: CR53 article-title: The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis publication-title: BJOG – volume: 176 start-page: e1016 issue: 998–1013 year: 2019 ident: CR40 article-title: Commensal microbiota promote lung cancer development via gammadelta T cells publication-title: Cell – volume: 586 start-page: 133 year: 2020 end-page: 138 ident: CR41 article-title: The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic publication-title: Nature – volume: 359 start-page: 97 year: 2018 end-page: 103 ident: CR28 article-title: Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients publication-title: Science – volume: 18 start-page: 571 year: 2001 end-page: 588 ident: CR56 article-title: Lung mucosal immunity: immunoglobulin—a revisited publication-title: Eur Respir J – volume: 7 start-page: 245 year: 2013 end-page: 257 ident: CR18 article-title: The role of the bacterial microbiome in lung disease publication-title: Expert Rev Respir Med – volume: 77 start-page: 4696 year: 2009 end-page: 4703 ident: CR58 article-title: Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae publication-title: Infect Immun – volume: 368 start-page: 973 year: 2020 end-page: 980 ident: CR52 article-title: The human tumor microbiome is composed of tumor type-specific intracellular bacteria publication-title: Science – volume: 4 start-page: eaao4502 year: 2018 ident: CR51 article-title: A commensal strain of protects against skin neoplasia publication-title: Sci Adv – volume: 246 start-page: 379 year: 2012 end-page: 400 ident: CR20 article-title: NF-kappaB and the link between inflammation and cancer publication-title: Immunol Rev – volume: 14 start-page: 207 year: 2013 end-page: 215 ident: CR42 article-title: potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment publication-title: Cell Host Microbe – volume: 38 start-page: 649 year: 2020 end-page: 671 ident: CR64 article-title: Cruel to be kind: epithelial, microbial, and immune cell interactions in gastrointestinal cancers publication-title: Annu Rev Immunol – volume: 326 start-page: 1694 year: 2009 end-page: 1697 ident: CR14 article-title: Bacterial community variation in human body habitats across space and time publication-title: Science (New York NY) – volume: 64 start-page: 435 year: 2019 end-page: 442 ident: CR50 article-title: Melanoma-related changes in skin microbiome publication-title: Folia Microbiol (Praha) – volume: 91 start-page: 233 year: 1987 end-page: 236 ident: CR6 article-title: Use of the protected specimen brush in patients with endotracheal or tracheostomy tubes publication-title: Chest – volume: 184 start-page: 957 year: 2011 end-page: 963 ident: CR12 article-title: Topographical continuity of bacterial populations in the healthy human respiratory tract publication-title: Am J Respir Crit Care Med – volume: 6 start-page: e16384 year: 2011 ident: CR23 article-title: Analysis of the lung microbiome in the “healthy” smoker and in COPD publication-title: PLoS ONE – volume: 82 start-page: 5039 year: 2016 end-page: 5048 ident: CR74 article-title: The microbiota of breast tissue and its association with breast cancer publication-title: Appl Environ Microbiol – volume: 19 start-page: 123 year: 2018 ident: CR30 article-title: Interaction between the microbiome and TP53 in human lung cancer publication-title: Genome Biol – volume: 22 start-page: 292 year: 2012 end-page: 298 ident: CR43 article-title: Genomic analysis identifies association of with colorectal carcinoma publication-title: Genome Res – volume: 486 start-page: 207 year: 2012 end-page: 214 ident: CR38 article-title: Structure, function and diversity of the healthy human microbiome publication-title: Nature – volume: 42 start-page: 344 year: 2015 end-page: 355 ident: CR32 article-title: Binding of the Fap2 protein of to human inhibitory receptor TIGIT protects tumors from immune cell attack publication-title: Immunity – volume: 146 start-page: 1534 year: 2014 end-page: 1546.e1533 ident: CR1 article-title: Gastrointestinal malignancy and the microbiome publication-title: Gastroenterology – volume: 342 start-page: 967 year: 2013 end-page: 970 ident: CR39 article-title: Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment publication-title: Science – volume: 358 start-page: 1443 year: 2017 end-page: 1448 ident: CR9 article-title: Analysis of persistence and antibiotic response in colorectal cancer publication-title: Science – volume: 350 start-page: 1084 year: 2015 end-page: 1089 ident: CR70 article-title: Commensal promotes antitumor immunity and facilitates anti-PD-L1 efficacy publication-title: Science – volume: 6 start-page: 5932 year: 2015 ident: CR36 article-title: Innate sensing of microbial products promotes wound-induced skin cancer publication-title: Nat Commun – volume: 198 start-page: 1188 year: 2018 end-page: 1198 ident: CR73 article-title: Airway microbiota is associated with upregulation of the PI3K pathway in lung cancer publication-title: Am J Respir Crit Care Med – volume: 22 start-page: 349 year: 2009 end-page: 369 ident: CR63 article-title: Enterotoxigenic : a rogue among symbiotes publication-title: Clin Microbiol Rev – volume: 196 start-page: 4839 year: 2016 end-page: 4847 ident: CR55 article-title: The lung microbiome, immunity, and the pathogenesis of chronic lung disease publication-title: J Immunol – volume: 102 start-page: 89 year: 2016 end-page: 95 ident: CR45 article-title: Characterization of microbiome in bronchoalveolar lavage fluid of patients with lung cancer comparing with benign mass like lesions publication-title: Lung Cancer – volume: 46 start-page: 549 year: 2017 end-page: 561 ident: CR48 article-title: Lung homeostasis: influence of age, microbes, and the immune system publication-title: Immunity – volume: 142 start-page: 769 year: 2018 end-page: 778 ident: CR47 article-title: Difference of lower airway microbiome in bilateral protected specimen brush between lung cancer patients with unilateral lobar masses and control subjects publication-title: Int J Cancer – volume: 157 start-page: 121 year: 2014 end-page: 141 ident: CR7 article-title: Role of the microbiota in immunity and inflammation publication-title: Cell – volume: 359 start-page: 91 year: 2018 end-page: 97 ident: CR61 article-title: Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors publication-title: Science – volume: 342 start-page: 971 year: 2013 end-page: 976 ident: CR76 article-title: The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide publication-title: Science – volume: 170 start-page: 548 year: 2017 end-page: 563.e516 ident: CR82 article-title: promotes chemoresistance to colorectal cancer by modulating autophagy publication-title: Cell – volume: 574 start-page: 264 year: 2019 end-page: 267 ident: CR3 article-title: The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL publication-title: Nature – volume: 35 start-page: 199 year: 2017 end-page: 228 ident: CR21 article-title: Microbes and cancer publication-title: Annu Rev Immunol – volume: 14 start-page: 195 year: 2013 end-page: 206 ident: CR62 article-title: promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin publication-title: Cell Host Microbe – volume: 69 start-page: 143 year: 2013 end-page: 155 ident: CR13 article-title: The skin microbiome: current perspectives and future challenges publication-title: J Am Acad Dermatol – volume: 24 start-page: 3528 year: 2018 end-page: 3538 ident: CR44 article-title: Modulation of pulmonary microbiota by antibiotic or probiotic aerosol therapy: a strategy to promote immunosurveillance against lung metastases publication-title: Cell Rep – volume: 5 start-page: e8578 year: 2010 ident: CR35 article-title: Disordered microbial communities in asthmatic airways publication-title: PLoS ONE – volume: 69 start-page: 7 year: 2019 end-page: 34 ident: CR69 article-title: Cancer statistics, 2019 publication-title: CA Cancer J Clin – volume: 364 start-page: 1133 year: 2019 end-page: 1135 ident: CR25 article-title: The gut microbiota and colon cancer publication-title: Science – volume: 551 start-page: 512 year: 2017 end-page: 516 ident: CR4 article-title: Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer publication-title: Nature – volume: 22 start-page: 5574 year: 2016 end-page: 5581 ident: CR79 article-title: Human microbiome in esophageal cancer tissue is associated with prognosis publication-title: Clin Cancer Res – volume: 17 start-page: 163 year: 2016 ident: CR81 article-title: Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features publication-title: Genome Biol – volume: 6 start-page: 30751 year: 2016 ident: CR34 article-title: The microbiome of aseptically collected human breast tissue in benign and malignant disease publication-title: Sci Rep – volume: 217 start-page: e20192282 issue: 5 year: 2020 ident: CR67 article-title: Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling publication-title: J Exp Med – volume: 9 start-page: 951 year: 2018 ident: CR5 article-title: Distinct microbial signatures associated with different breast cancer types publication-title: Front Microbiol – volume: 77 start-page: 2739 year: 2020 end-page: 2749 ident: CR71 article-title: The lung microbiota: role in maintaining pulmonary immune homeostasis and its implications in cancer development and therapy publication-title: Cell Mol Life Sci – volume: 384 start-page: 691 year: 2014 end-page: 702 ident: CR19 article-title: The role of the microbiome in exacerbations of chronic lung diseases publication-title: Lancet – volume: 10 start-page: 299 year: 2017 end-page: 306 ident: CR37 article-title: The respiratory tract microbiome and lung inflammation: a two-way street publication-title: Mucosal Immunol – volume: 13 start-page: 759 year: 2013 end-page: 771 ident: CR22 article-title: Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms publication-title: Nat Rev Cancer – volume: 359 start-page: 104 year: 2018 end-page: 108 ident: CR49 article-title: The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients publication-title: Science – volume: 6 start-page: 86 year: 2020 end-page: 97 ident: CR59 article-title: The influence of lung microbiota on lung carcinogenesis, immunity, and immunotherapy publication-title: Trends Cancer – volume: 338 start-page: 120 year: 2012 ident: 813_CR2 publication-title: Science doi: 10.1126/science.1224820 – volume: 9 start-page: 951 year: 2018 ident: 813_CR5 publication-title: Front Microbiol doi: 10.3389/fmicb.2018.00951 – volume: 142 start-page: 769 year: 2018 ident: 813_CR47 publication-title: Int J Cancer doi: 10.1002/ijc.31098 – volume: 22 start-page: 349 year: 2009 ident: 813_CR63 publication-title: Clin Microbiol Rev doi: 10.1128/CMR.00053-08 – volume: 17 start-page: 163 year: 2016 ident: 813_CR81 publication-title: Genome Biol doi: 10.1186/s13059-016-1021-1 – volume: 178 start-page: 795 year: 2019 ident: 813_CR60 publication-title: Cell doi: 10.1016/j.cell.2019.07.008 – volume: 313 start-page: 848 year: 2006 ident: 813_CR54 publication-title: Science doi: 10.1126/science.1127059 – volume: 196 start-page: 4839 year: 2016 ident: 813_CR55 publication-title: J Immunol doi: 10.4049/jimmunol.1600279 – volume: 217 start-page: e20192282 issue: 5 year: 2020 ident: 813_CR67 publication-title: J Exp Med doi: 10.1084/jem.20192282 – volume: 348 start-page: 80 year: 2015 ident: 813_CR24 publication-title: Science doi: 10.1126/science.aaa4972 – volume: 19 start-page: 123 year: 2018 ident: 813_CR30 publication-title: Genome Biol doi: 10.1186/s13059-018-1501-6 – volume: 127 start-page: 171 year: 2020 ident: 813_CR53 publication-title: BJOG doi: 10.1111/1471-0528.15854 – volume: 18 start-page: 571 year: 2001 ident: 813_CR56 publication-title: Eur Respir J doi: 10.1183/09031936.01.00228801 – volume: 486 start-page: 207 year: 2012 ident: 813_CR38 publication-title: Nature doi: 10.1038/nature11234 – volume: 14 start-page: 207 year: 2013 ident: 813_CR42 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2013.07.007 – volume: 574 start-page: 264 year: 2019 ident: 813_CR3 publication-title: Nature doi: 10.1038/s41586-019-1608-2 – volume: 359 start-page: 592 year: 2018 ident: 813_CR16 publication-title: Science doi: 10.1126/science.aah3648 – volume: 6 start-page: e16384 year: 2011 ident: 813_CR23 publication-title: PLoS ONE doi: 10.1371/journal.pone.0016384 – volume: 124 start-page: 837 year: 2006 ident: 813_CR46 publication-title: Cell doi: 10.1016/j.cell.2006.02.017 – volume: 6 start-page: 5932 year: 2015 ident: 813_CR36 publication-title: Nat Commun doi: 10.1038/ncomms6932 – volume: 77 start-page: 2739 year: 2020 ident: 813_CR71 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-020-03452-8 – volume: 363 start-page: eaar7785 year: 2019 ident: 813_CR78 publication-title: Science doi: 10.1126/science.aar7785 – volume: 22 start-page: 5574 year: 2016 ident: 813_CR79 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-16-1786 – volume: 10 start-page: 1310 year: 2017 ident: 813_CR66 publication-title: Mucosal Immunol doi: 10.1038/mi.2016.129 – volume: 157 start-page: 121 year: 2014 ident: 813_CR7 publication-title: Cell doi: 10.1016/j.cell.2014.03.011 – volume: 38 start-page: 649 year: 2020 ident: 813_CR64 publication-title: Annu Rev Immunol doi: 10.1146/annurev-immunol-082019-081656 – volume: 68 start-page: 7 year: 2018 ident: 813_CR68 publication-title: CA Cancer J Clin doi: 10.3322/caac.21442 – volume: 358 start-page: 1443 year: 2017 ident: 813_CR9 publication-title: Science doi: 10.1126/science.aal5240 – volume: 364 start-page: 1133 year: 2019 ident: 813_CR25 publication-title: Science doi: 10.1126/science.aaw2367 – volume: 77 start-page: 4696 year: 2009 ident: 813_CR58 publication-title: Infect Immun doi: 10.1128/IAI.00522-09 – volume: 14 start-page: 646 year: 2013 ident: 813_CR8 publication-title: Nat Immunol doi: 10.1038/ni.2604 – volume: 13 start-page: 759 year: 2013 ident: 813_CR22 publication-title: Nat Rev Cancer doi: 10.1038/nrc3611 – volume: 384 start-page: 691 year: 2014 ident: 813_CR19 publication-title: Lancet doi: 10.1016/S0140-6736(14)61136-3 – volume: 22 start-page: 292 year: 2012 ident: 813_CR43 publication-title: Genome Res doi: 10.1101/gr.126573.111 – volume: 69 start-page: 143 year: 2013 ident: 813_CR13 publication-title: J Am Acad Dermatol doi: 10.1016/j.jaad.2013.01.016 – volume: 368 start-page: 973 year: 2020 ident: 813_CR52 publication-title: Science doi: 10.1126/science.aay9189 – volume: 46 start-page: 549 year: 2017 ident: 813_CR48 publication-title: Immunity doi: 10.1016/j.immuni.2017.04.005 – volume: 155 start-page: 855 year: 1987 ident: 813_CR72 publication-title: J Infect Dis doi: 10.1093/infdis/155.5.855 – volume: 13 start-page: 607 year: 2012 ident: 813_CR15 publication-title: Lancet Oncol doi: 10.1016/S1470-2045(12)70137-7 – volume: 551 start-page: 512 year: 2017 ident: 813_CR4 publication-title: Nature doi: 10.1038/nature24462 – volume: 7 start-page: 245 year: 2013 ident: 813_CR18 publication-title: Expert Rev Respir Med doi: 10.1586/ers.13.24 – volume: 246 start-page: 379 year: 2012 ident: 813_CR20 publication-title: Immunol Rev doi: 10.1111/j.1600-065X.2012.01099.x – volume: 9 start-page: 12838 year: 2019 ident: 813_CR27 publication-title: Sci Rep doi: 10.1038/s41598-019-49195-w – volume: 326 start-page: 1694 year: 2009 ident: 813_CR14 publication-title: Science (New York NY) doi: 10.1126/science.1177486 – volume: 2 start-page: 26ra25 year: 2010 ident: 813_CR33 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3000251 – volume: 357 start-page: 1156 year: 2017 ident: 813_CR26 publication-title: Science doi: 10.1126/science.aah5043 – volume: 4 start-page: eaao4502 year: 2018 ident: 813_CR51 publication-title: Sci Adv doi: 10.1126/sciadv.aao4502 – volume: 82 start-page: 5039 year: 2016 ident: 813_CR74 publication-title: Appl Environ Microbiol doi: 10.1128/AEM.01235-16 – volume: 69 start-page: 7 year: 2019 ident: 813_CR69 publication-title: CA Cancer J Clin doi: 10.3322/caac.21551 – volume: 278 start-page: 4577 year: 2011 ident: 813_CR31 publication-title: FEBS J doi: 10.1111/j.1742-4658.2011.08125.x – volume: 176 start-page: e1016 issue: 998–1013 year: 2019 ident: 813_CR40 publication-title: Cell – volume: 6 start-page: 86 year: 2020 ident: 813_CR59 publication-title: Trends Cancer doi: 10.1016/j.trecan.2019.12.007 – volume: 170 start-page: 548 year: 2017 ident: 813_CR82 publication-title: Cell doi: 10.1016/j.cell.2017.07.008 – volume: 24 start-page: 3528 year: 2018 ident: 813_CR44 publication-title: Cell Rep doi: 10.1016/j.celrep.2018.08.090 – volume: 146 start-page: 1534 year: 2014 ident: 813_CR1 publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.01.001 – volume: 102 start-page: 89 year: 2016 ident: 813_CR45 publication-title: Lung Cancer doi: 10.1016/j.lungcan.2016.10.016 – volume: 91 start-page: 233 year: 1987 ident: 813_CR6 publication-title: Chest doi: 10.1378/chest.91.2.233 – volume: 8 start-page: 33972 year: 2017 ident: 813_CR65 publication-title: OncoTarget doi: 10.18632/oncotarget.15687 – volume: 342 start-page: 967 year: 2013 ident: 813_CR39 publication-title: Science doi: 10.1126/science.1240527 – volume: 5 start-page: 670 year: 2019 ident: 813_CR77 publication-title: Trends Cancer doi: 10.1016/j.trecan.2019.10.005 – volume: 12 start-page: e0177062 year: 2017 ident: 813_CR10 publication-title: PLoS ONE doi: 10.1371/journal.pone.0177062 – volume: 184 start-page: 957 year: 2011 ident: 813_CR12 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201104-0655OC – volume: 38 start-page: 158 year: 2020 ident: 813_CR29 publication-title: Cancer Cell doi: 10.1016/j.ccell.2020.06.017 – volume: 359 start-page: 104 year: 2018 ident: 813_CR49 publication-title: Science doi: 10.1126/science.aao3290 – volume: 8 start-page: 403 year: 2018 ident: 813_CR57 publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-17-1134 – volume: 350 start-page: 1079 year: 2015 ident: 813_CR75 publication-title: Science doi: 10.1126/science.aad1329 – volume: 12 start-page: 821 year: 2015 ident: 813_CR17 publication-title: Ann Am Thorac Soc doi: 10.1513/AnnalsATS.201501-029OC – volume: 14 start-page: 195 year: 2013 ident: 813_CR62 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2013.07.012 – volume: 5 start-page: e8578 year: 2010 ident: 813_CR35 publication-title: PLoS ONE doi: 10.1371/journal.pone.0008578 – volume: 64 start-page: 435 year: 2019 ident: 813_CR50 publication-title: Folia Microbiol (Praha) doi: 10.1007/s12223-018-00670-3 – volume: 22 start-page: 299 year: 2012 ident: 813_CR11 publication-title: Genome Res doi: 10.1101/gr.126516.111 – volume: 6 start-page: 30751 year: 2016 ident: 813_CR34 publication-title: Sci Rep doi: 10.1038/srep30751 – volume: 198 start-page: 1188 year: 2018 ident: 813_CR73 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201710-2118OC – volume: 359 start-page: 97 year: 2018 ident: 813_CR28 publication-title: Science doi: 10.1126/science.aan4236 – volume: 42 start-page: 344 year: 2015 ident: 813_CR32 publication-title: Immunity doi: 10.1016/j.immuni.2015.01.010 – volume: 359 start-page: 91 year: 2018 ident: 813_CR61 publication-title: Science doi: 10.1126/science.aan3706 – volume: 10 start-page: 299 year: 2017 ident: 813_CR37 publication-title: Mucosal Immunol doi: 10.1038/mi.2016.108 – volume: 5 start-page: 3111 year: 2015 ident: 813_CR80 publication-title: Am J Cancer Res – volume: 35 start-page: 199 year: 2017 ident: 813_CR21 publication-title: Annu Rev Immunol doi: 10.1146/annurev-immunol-051116-052133 – volume: 350 start-page: 1084 year: 2015 ident: 813_CR70 publication-title: Science doi: 10.1126/science.aac4255 – volume: 342 start-page: 971 year: 2013 ident: 813_CR76 publication-title: Science doi: 10.1126/science.1240537 – volume: 586 start-page: 133 year: 2020 ident: 813_CR41 publication-title: Nature doi: 10.1038/s41586-020-2541-0
SSID	ssj0000331567
Score	2.6326437
SecondaryResourceType	review_article
Snippet	Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known...
SourceID	pubmedcentral proquest pubmed crossref springer higheredpress
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	426
SubjectTerms	Bacteria - metabolism Biochemistry Biomedical and Life Sciences Cancer cancer immunotherapy Cell Biology Developmental Biology Gastrointestinal Microbiome Gastrointestinal tract Human Genetics Humans immune system Intestine Life Sciences Lung cancer microbiome Microbiomes Microbiota Mucosa Neoplasms - metabolism Neoplasms - microbiology Protein Science Review Stem Cells tumor Tumor Microenvironment tumor-associated microbiota Tumors
SummonAdditionalLinks	– databaseName: SpringerLINK dbid: C24 link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dSxwxEB9a24JQWls_uq2VLfimgWySvU36VkTpQxEfFO5t2cwm9UD35D4E_3sz2d07z1qhfU0mSzaZJDPMb34DsI-ZqaQZ1AyV8UzVCpnlmWX5ILRbbW3t4k7_Kk5P9XBozrqksGmPdu9DkvGmXia7yfC8MHJ36B2TTL-EV3mmDQH5jroch3j_ShmcklhVZVCocAXzYZct8_RnVl6kt5cRXuHqCEN9yuz8Ez35KIQaX6aT9__3TxvwrrNE0x-t6nyAF675CG_a2pR3m3B80RD7PwaLNP1NU5umoyYN5mI6m1-PJ-k1IfkepMl9b1tiOj9JIqnTZAvOT47Pj36yruYCw1yoGZO18DavnKu4kc4LVdARV7WshETrFFbcZ5bnPlgyWYV5gcJyI8L1LdBoK7dhrRk37hOk3nMnNHfIdaF85bRCJzwihZ2J5yuBrF_2Ejs-ciqLcVUumZRpdcqwOmVcnVIncLAYc9OycTwrLVZ2s_TECUEVxp8dtNtvedkd52kpgrtOEAUtE_i26A4HkaIrVePG8yCjBjqYc8HnT2Cn1ZDFHKUURIJjEihWdGchQCTfqz3N6DKSfevgsweTL4HDXoOW0_r7X3z-N_EvsC4IqxOBnLuwNpvM3Vd4jbez0XSyF4_XPRQRHeo priority: 102 providerName: Springer Nature
Title	Unexpected guests in the tumor microenvironment: microbiome in cancer
URI	https://journal.hep.com.cn/pac/EN/10.1007/s13238-020-00813-8 https://link.springer.com/article/10.1007/s13238-020-00813-8 https://www.ncbi.nlm.nih.gov/pubmed/33296049 https://www.proquest.com/docview/2523913483 https://www.proquest.com/docview/2468658133 https://pubmed.ncbi.nlm.nih.gov/PMC8106554
Volume	12
WOSCitedRecordID	wos000597722700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: Directory of Open Access Journals customDbUrl: eissn: 1674-8018 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0000331567 issn: 1674-800X databaseCode: DOA dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVASL databaseName: Oxford Journals Open Access Collection (WRLC) customDbUrl: eissn: 1674-8018 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000331567 issn: 1674-800X databaseCode: TOX dateStart: 20100101 isFulltext: true titleUrlDefault: https://academic.oup.com/journals/ providerName: Oxford University Press – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1674-8018 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000331567 issn: 1674-800X databaseCode: M7P dateStart: 20120901 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1674-8018 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000331567 issn: 1674-800X databaseCode: 7X7 dateStart: 20120901 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1674-8018 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000331567 issn: 1674-800X databaseCode: BENPR dateStart: 20120901 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1674-8018 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000331567 issn: 1674-800X databaseCode: PIMPY dateStart: 20120901 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerOpen customDbUrl: eissn: 1674-8018 dateEnd: 20221231 omitProxy: false ssIdentifier: ssj0000331567 issn: 1674-800X databaseCode: C24 dateStart: 20100101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3di9QwEB-8OwVB_PasnksF3zRcmqTb1BfRYw8FXYusUJ9Kmybewl333A_B_96ZtNt1_dgXXwpJJiVhJslMZvIbgGcmSkuZDmtmVOqYqpVhFY8qFg-xvtJVVVvP6ffJeKzzPM26C7dFF1a53hP9Rl3PDN2RHwu0mMhLrOWry2-MskaRd7VLobEHB4SSIHzoXtbfsXAp0Tzx-VWGicLNmOfdu5n29ZzE84qR_UQHo2R662y6ceYDLWztA1L_poD-GUf5mzPVn1Gnt_53drfhZqedhq9bcboDV2xzF661-Sp_3IPR54YyAhjUUsOv9PdFOG1CVCHD5epiNg8vKLrvl6dzL9sa_8SfKA2J2Pw-TE5Hk5O3rMvDwEws1JLJWrgqLq0teSqtEyqhZa9qWQppKqtMyV1U8dihdhOVJk6MqHgqcEsXJtWVfAD7zayxDyF0jluhuTVcJ8qVVitjhTOGXNGE_RVAtGZAYTqMckqVcV5s0JWJaQUyrfBMK3QAz_s-ly1Cx05qscXXwhFOBGUd39npaM21olvii2LDsgCe9s24OMnjUjZ2tkIaNdSo4kUSaQ5bWenHKKUgYJw0gGRLinoCAv7ebmmmZx4AXKMdj2pgAC_W8rYZ1r9n8Wj3LB7DdUHxOj6Y8wj2l_OVfQJXzffldDEfwF6SJ_6rB3DwZjTOPmHpRKiBv8UY-IWHLdm7D9kXLE0-5j8B2yUwjA
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFD4aHWhIiPslMCBI8AQWie00DhJCCDatWlf1oUjlyYode6vE0tELaD-K_4iPcynl0rc98JqcRHH8-Vx8jr8D8FzHWc6ybkE0zyzhBddERbEiSdddV0KpwviZ7qeDgRiPs-EW_GjOwmBZZaMTvaIuphr3yF9TFzFhlliwd2dfCXaNwuxq00KjgsWhOf_uQrb5295HN78vKN3fG304IHVXAaITyheEFdSqJDcmd8G8sZSnCGJesJwyrQzXeWRjFSXW2eo410mqqYoy6hQU1ZlQzL32EmxzxHoHtoe9o-HndlMnYszFQ76hSzflTvtH4_qgTnVcjzkDSTBgQ0vMiFgzhtdOfGWHKXwF7N883j8LN3_L3nqjuH_jP_udN-F67X2H76vlcgu2THkbrlT9OM_vwN6nEjseaOeFh8c4mHk4KUPnIoeL5el0Fp5i9eIvRwPfVFc8hQFKalxCs7swuogh3INOOS3NAwitjQwVkdGRSLnNjeDaUKs1ptqR2yyAuJlvqWsOdmwF8kWu2KMRI9JhRHqMSBHAy_aZs4qBZKM0XYORtMiDgV3VNz6024BE1ipsLlcICeBZe9spH8wo5aWZLp0M7wrnwsbMydyvoNl-I2MUiX-yANI10LYCSGy-fqecnHiCcxE7xzjhAbxq4L36rH-P4uHmUTyFnYPRUV_2e4PDR3CVYm2SL1zdhc5itjSP4bL-tpjMZ0_qVR2CvGDg_wSHP4f1
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Zj9MwEB4tXUBIiPsILBAkeAJrE9tpHCSEELsV1S5VHxapPFmxY7OV2HTpAdqfxr9jJkdLOfq2D7wmkyiOP8_hGX8D8MzGWS6ybsGszDyThbTMRLFhSRevG2VM4aqZPkwHAzUaZcMt-NGehaGyylYnVoq6mFjaI9_lGDFRlliJXd-URQz3em9OvzLqIEWZ1radRg2RA3f2HcO32ev-Hs71c857-0fv3rOmwwCzCZdzJgruTZI7l2Ng7zyXKQFaFiLnwhonbR752ESJR7sd5zZJLTdRxlFZcZspI_C1F2AbPXLJO7A97H8Yflpu8ERCYGxUNXfpphItQTRqDu3UR_cEGktGwRtZZcHUmmG8elxVebiiqob9m_f7ZxHnb5ncykD2rv_Hv_YGXGu88vBtvYxuwpYrb8Gluk_n2W3Y_1hSJwSL3nn4mQY2C8dliK5zOF-cTKbhCVU1_nJk8FV9paI2IElLS2t6B47OYwh3oVNOSncfQu8jx1XkbKRS6XOnpHXcW0speOI8CyBu517bhpudWoR80StWacKLRrzoCi9aBfBi-cxpzUyyUZqvQUp74segbusbH9ppAaMb1TbTK7QE8HR5G5USZZry0k0WKCO7Cl3bWKDMvRqmy28UghMhUBZAugbgpQARnq_fKcfHFfG5itFhTmQAL1uorz7r36N4sHkUT-Ayol0f9gcHD-EKp5Klqp51Bzrz6cI9gov223w8mz5uFngI-pxx_xMVw5C1
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Unexpected+guests+in+the+tumor+microenvironment%3A+microbiome+in+cancer&rft.jtitle=Protein+%26+cell&rft.au=Wong-Rolle%2C+Abigail&rft.au=Wei%2C+Haohan+Karen&rft.au=Zhao%2C+Chen&rft.au=Jin%2C+Chengcheng&rft.date=2021-05-01&rft.issn=1674-800X&rft.eissn=1674-8018&rft.volume=12&rft.issue=5&rft.spage=426&rft.epage=435&rft_id=info:doi/10.1007%2Fs13238-020-00813-8&rft.externalDBID=n%2Fa&rft.externalDocID=10_1007_s13238_020_00813_8
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1674-800X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1674-800X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1674-800X&client=summon