Unexpected guests in the tumor microenvironment: microbiome in cancer

Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has reveale d that the local microbiota make up an important part o...

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Vydáno v:	Protein & cell Ročník 12; číslo 5; s. 426 - 435
Hlavní autoři:	Wong-Rolle, Abigail, Wei, Haohan Karen, Zhao, Chen, Jin, Chengcheng
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Beijing Higher Education Press 01.05.2021 Springer Nature B.V
Témata:	Bacteria - metabolism Biochemistry Biomedical and Life Sciences Cancer cancer immunotherapy Cell Biology Developmental Biology Gastrointestinal Microbiome Gastrointestinal tract Human Genetics Humans immune system Intestine Life Sciences Lung cancer microbiome Microbiomes Microbiota Mucosa Neoplasms - metabolism Neoplasms - microbiology Protein Science Review Stem Cells tumor Tumor Microenvironment tumor-associated microbiota Tumors lung cancer tumor-associated microbiota immune system microbiome tumor cancer immunotherapy
ISSN:	1674-800X, 1674-8018, 1674-8018
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Abstract	Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has reveale d that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment.
AbstractList	Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has revealed that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment.Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has revealed that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment. Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has reveale d that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment. Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has revealed that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment.
Author	Wei, Haohan Karen Zhao, Chen Jin, Chengcheng Wong-Rolle, Abigail
Author_xml	– sequence: 1 givenname: Abigail surname: Wong-Rolle fullname: Wong-Rolle, Abigail organization: Thoracic and Gastrointestinal Malignancies Branch, National Cancer Institute, National Institutes of Health, 4 Memorial Drive, Bethesda, MD 20892, USA – sequence: 2 givenname: Haohan Karen surname: Wei fullname: Wei, Haohan Karen organization: Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd., Philadelphia, PA 19104, USA – sequence: 3 givenname: Chen surname: Zhao fullname: Zhao, Chen email: chen.zhao@nih.gov (C. Zhao) organization: Thoracic and Gastrointestinal Malignancies Branch, National Cancer Institute, National Institutes of Health, 4 Memorial Drive, Bethesda, MD 20892, USA – sequence: 4 givenname: Chengcheng surname: Jin fullname: Jin, Chengcheng email: Chengcheng.Jin@Pennmedicine.upenn.edu (C. Jin) organization: Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd., Philadelphia, PA 19104, USA
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Issue	5
Keywords	lung cancer tumor-associated microbiota immune system microbiome tumor cancer immunotherapy
Language	English
License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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Notes	lung cancer tumor-associated microbiota Document received on :2020-08-23 tumor cancer immunotherapy immune system Document accepted on :2020-11-01 microbiome ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
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Publisher	Higher Education Press Springer Nature B.V
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Snippet	Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known...
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SubjectTerms	Bacteria - metabolism Biochemistry Biomedical and Life Sciences Cancer cancer immunotherapy Cell Biology Developmental Biology Gastrointestinal Microbiome Gastrointestinal tract Human Genetics Humans immune system Intestine Life Sciences Lung cancer microbiome Microbiomes Microbiota Mucosa Neoplasms - metabolism Neoplasms - microbiology Protein Science Review Stem Cells tumor Tumor Microenvironment tumor-associated microbiota Tumors
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Title	Unexpected guests in the tumor microenvironment: microbiome in cancer
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