Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events

In a large study in 17 countries, an estimated sodium intake that was either higher or lower than the average estimated sodium intake was associated with an increased risk of cardiovascular events. A higher-than-average potassium intake was associated with reduced risk. Most of the global population...

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Vydané v:	The New England journal of medicine Ročník 371; číslo 7; s. 612 - 623
Hlavní autori:	O'Donnell, Martin, Mente, Andrew, Rangarajan, Sumathy, McQueen, Matthew J, Wang, Xingyu, Liu, Lisheng, Yan, Hou, Lee, Shun Fu, Mony, Prem, Devanath, Anitha, Rosengren, Annika, Lopez-Jaramillo, Patricio, Diaz, Rafael, Avezum, Alvaro, Lanas, Fernando, Yusoff, Khalid, Iqbal, Romaina, Ilow, Rafal, Mohammadifard, Noushin, Gulec, Sadi, Yusufali, Afzal Hussein, Kruger, Lanthe, Yusuf, Rita, Chifamba, Jephat, Kabali, Conrad, Dagenais, Gilles, Lear, Scott A, Teo, Koon, Yusuf, Salim
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Waltham, MA Massachusetts Medical Society 14.08.2014
Predmet:	Adult Biological and medical sciences Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases/epidemiology/etiology Clinical Medicine Death Diet Dietary/administration & dosage/adverse effects Epidemiology Excretion Family medical history Female Follow-Up Studies General aspects Health risk assessment Humans Klinisk medicin Linear Models Male Medical research Medical sciences Middle Aged Mortality Potassium Potassium - administration & dosage Potassium - urine Potassium/administration & dosage/urine Sodium Sodium - urine Sodium, Dietary - administration & dosage Sodium, Dietary - adverse effects Urine Ontario Canada Canada Turkey China India Medicine Excretion Prognosis Sodium Mortality Inorganic element Potassium
ISSN:	0028-4793, 1533-4406, 1533-4406
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Shrnutí:	In a large study in 17 countries, an estimated sodium intake that was either higher or lower than the average estimated sodium intake was associated with an increased risk of cardiovascular events. A higher-than-average potassium intake was associated with reduced risk. Most of the global population consumes between 3.0 and 6.0 g of sodium per day (7.5 to 15.0 g of salt per day). 1 , 2 Guidelines on cardiovascular disease prevention recommend a maximum sodium intake of 1.5 to 2.4 g per day, but achieving this target will require a substantial change in diet for most people. 3 – 5 Although clinical trials have shown a reduction in blood pressure with a reduced sodium intake, to our knowledge, no large randomized trial has been conducted to document reductions in the risk of cardiovascular disease with low sodium intake. 6 Prospective cohort studies have shown inconsistent . . .
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1311889