Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures

Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons and in diverse populations is unknown. We applied systems approaches to study immune responses in young, elderly, and di...

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Veröffentlicht in:Immunity (Cambridge, Mass.) Jg. 43; H. 6; S. 1186 - 1198
Hauptverfasser: Nakaya, Helder I, Hagan, Thomas, Duraisingham, Sai S, Lee, Eva K, Kwissa, Marcin, Rouphael, Nadine, Frasca, Daniela, Gersten, Merril, Mehta, Aneesh K, Gaujoux, Renaud, Li, Gui-Mei, Gupta, Shakti, Ahmed, Rafi, Mulligan, Mark J, Shen-Orr, Shai, Blomberg, Bonnie B, Subramaniam, Shankar, Pulendran, Bali
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 15.12.2015
Schlagworte:
Adult
Aged
Antibodies, Viral - blood
Antibodies, Viral - genetics
Female
Flow Cytometry
Humans
Influenza Vaccines - immunology
Influenza, Human - prevention & control
Male
Middle Aged
Oligonucleotide Array Sequence Analysis
Seasons
Systems Analysis
Transcriptome - immunology
ISSN:1097-4180
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Zusammenfassung:Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons and in diverse populations is unknown. We applied systems approaches to study immune responses in young, elderly, and diabetic subjects vaccinated with the seasonal influenza vaccine across five consecutive seasons. Signatures of innate immunity and plasmablasts correlated with and predicted influenza antibody titers at 1 month after vaccination with >80% accuracy across multiple seasons but were not associated with the longevity of the response. Baseline signatures of lymphocyte and monocyte inflammation were positively and negatively correlated, respectively, with antibody responses at 1 month. Finally, integrative analysis of microRNAs and transcriptomic profiling revealed potential regulators of vaccine immunity. These results identify shared vaccine-induced signatures across multiple seasons and in diverse populations and might help guide the development of next-generation vaccines that provide persistent immunity against influenza.
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ISSN:1097-4180
DOI:10.1016/j.immuni.2015.11.012