Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures

Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons and in diverse populations is unknown. We applied systems approaches to study immune responses in young, elderly, and di...

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Vydané v:	Immunity (Cambridge, Mass.) Ročník 43; číslo 6; s. 1186 - 1198
Hlavní autori:	Nakaya, Helder I, Hagan, Thomas, Duraisingham, Sai S, Lee, Eva K, Kwissa, Marcin, Rouphael, Nadine, Frasca, Daniela, Gersten, Merril, Mehta, Aneesh K, Gaujoux, Renaud, Li, Gui-Mei, Gupta, Shakti, Ahmed, Rafi, Mulligan, Mark J, Shen-Orr, Shai, Blomberg, Bonnie B, Subramaniam, Shankar, Pulendran, Bali
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 15.12.2015
Predmet:	Adult Aged Antibodies, Viral - blood Antibodies, Viral - genetics Female Flow Cytometry Humans Influenza Vaccines - immunology Influenza, Human - prevention & control Male Middle Aged Oligonucleotide Array Sequence Analysis Seasons Systems Analysis Transcriptome - immunology
ISSN:	1097-4180
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Abstract	Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons and in diverse populations is unknown. We applied systems approaches to study immune responses in young, elderly, and diabetic subjects vaccinated with the seasonal influenza vaccine across five consecutive seasons. Signatures of innate immunity and plasmablasts correlated with and predicted influenza antibody titers at 1 month after vaccination with >80% accuracy across multiple seasons but were not associated with the longevity of the response. Baseline signatures of lymphocyte and monocyte inflammation were positively and negatively correlated, respectively, with antibody responses at 1 month. Finally, integrative analysis of microRNAs and transcriptomic profiling revealed potential regulators of vaccine immunity. These results identify shared vaccine-induced signatures across multiple seasons and in diverse populations and might help guide the development of next-generation vaccines that provide persistent immunity against influenza.
AbstractList	Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons and in diverse populations is unknown. We applied systems approaches to study immune responses in young, elderly, and diabetic subjects vaccinated with the seasonal influenza vaccine across five consecutive seasons. Signatures of innate immunity and plasmablasts correlated with and predicted influenza antibody titers at 1 month after vaccination with >80% accuracy across multiple seasons but were not associated with the longevity of the response. Baseline signatures of lymphocyte and monocyte inflammation were positively and negatively correlated, respectively, with antibody responses at 1 month. Finally, integrative analysis of microRNAs and transcriptomic profiling revealed potential regulators of vaccine immunity. These results identify shared vaccine-induced signatures across multiple seasons and in diverse populations and might help guide the development of next-generation vaccines that provide persistent immunity against influenza.
Author	Shen-Orr, Shai Duraisingham, Sai S Gaujoux, Renaud Frasca, Daniela Ahmed, Rafi Gersten, Merril Li, Gui-Mei Rouphael, Nadine Subramaniam, Shankar Pulendran, Bali Nakaya, Helder I Lee, Eva K Kwissa, Marcin Blomberg, Bonnie B Mehta, Aneesh K Gupta, Shakti Mulligan, Mark J Hagan, Thomas
Author_xml	– sequence: 1 givenname: Helder I surname: Nakaya fullname: Nakaya, Helder I organization: School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 580, São Paulo 05508, Brazil; Department of Pathology, School of Medicine, Emory University, 1648 Pierce Drive NE, Atlanta, GA 30307, USA – sequence: 2 givenname: Thomas surname: Hagan fullname: Hagan, Thomas organization: Department of Bioengineering, University of California, 9500 Gilman Drive MC 0412, San Diego, La Jolla, CA 92093, USA – sequence: 3 givenname: Sai S surname: Duraisingham fullname: Duraisingham, Sai S organization: Department of Immunology, Churchill Hospital, Oxford University Hospitals NHS Trust, Old Road, Oxford OX3 7J, UK – sequence: 4 givenname: Eva K surname: Lee fullname: Lee, Eva K organization: Center for Operations Research in Medicine & Healthcare, School of Industrial & Systems Engineering, Georgia Institute of Technology, North Avenue NW, Atlanta, GA 30332, USA – sequence: 5 givenname: Marcin surname: Kwissa fullname: Kwissa, Marcin organization: Institute for Molecular Engineering, University of Chicago, 5640 S. Elis Avenue, Chicago, IL 60637, USA – sequence: 6 givenname: Nadine surname: Rouphael fullname: Rouphael, Nadine organization: Hope Clinic of Emory University, 500 Irvin Court/Suite 200, Atlanta, GA 30030, USA – sequence: 7 givenname: Daniela surname: Frasca fullname: Frasca, Daniela organization: Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA – sequence: 8 givenname: Merril surname: Gersten fullname: Gersten, Merril organization: Department of Bioengineering, University of California, 9500 Gilman Drive MC 0412, San Diego, La Jolla, CA 92093, USA – sequence: 9 givenname: Aneesh K surname: Mehta fullname: Mehta, Aneesh K organization: Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, 1648 Pierce Drive NE, Atlanta, GA 30307, USA – sequence: 10 givenname: Renaud surname: Gaujoux fullname: Gaujoux, Renaud organization: Department of Immunology, Faculty of Medicine, Technion, 1 Efron Street, Haifa 3109601, Israel – sequence: 11 givenname: Gui-Mei surname: Li fullname: Li, Gui-Mei organization: Department of Microbiology and Immunology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA; Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA – sequence: 12 givenname: Shakti surname: Gupta fullname: Gupta, Shakti organization: Department of Bioengineering, University of California, 9500 Gilman Drive MC 0412, San Diego, La Jolla, CA 92093, USA – sequence: 13 givenname: Rafi surname: Ahmed fullname: Ahmed, Rafi organization: Department of Microbiology and Immunology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA; Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA – sequence: 14 givenname: Mark J surname: Mulligan fullname: Mulligan, Mark J organization: Hope Clinic of Emory University, 500 Irvin Court/Suite 200, Atlanta, GA 30030, USA – sequence: 15 givenname: Shai surname: Shen-Orr fullname: Shen-Orr, Shai organization: Department of Immunology, Faculty of Medicine, Technion, 1 Efron Street, Haifa 3109601, Israel – sequence: 16 givenname: Bonnie B surname: Blomberg fullname: Blomberg, Bonnie B organization: Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA – sequence: 17 givenname: Shankar surname: Subramaniam fullname: Subramaniam, Shankar email: shankar@ucsd.edu organization: Department of Bioengineering, University of California, 9500 Gilman Drive MC 0412, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA 92093, USA; Department of Nanoengineering, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA 92093, USA; Department of Computer Science and Engineering, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA 92093, USA. Electronic address: shankar@ucsd.edu – sequence: 18 givenname: Bali surname: Pulendran fullname: Pulendran, Bali email: bpulend@emory.edu organization: Department of Pathology, School of Medicine, Emory University, 1648 Pierce Drive NE, Atlanta, GA 30307, USA; Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. Electronic address: bpulend@emory.edu
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SubjectTerms	Adult Aged Antibodies, Viral - blood Antibodies, Viral - genetics Female Flow Cytometry Humans Influenza Vaccines - immunology Influenza, Human - prevention & control Male Middle Aged Oligonucleotide Array Sequence Analysis Seasons Systems Analysis Transcriptome - immunology
Title	Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures
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