Leisure-time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study

We tested the hypotheses that higher levels of and persistence of midlife leisure-time physical activity (LTPA) are associated long-term with lower cognitive decline and less incident dementia. A total of 10,705 participants (mean age: 60 years) had LTPA (no, low, middle, or high) measured in 1987-1...

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Veröffentlicht in:Alzheimer's & dementia Jg. 15; H. 2; S. 273
Hauptverfasser: Palta, Priya, Sharrett, A Richey, Deal, Jennifer A, Evenson, Kelly R, Gabriel, Kelley Pettee, Folsom, Aaron R, Gross, Alden L, Windham, B Gwen, Knopman, David, Mosley, Thomas H, Heiss, Gerardo
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.02.2019
Schlagworte:
Age Factors
Atherosclerosis - epidemiology
Cognition - physiology
Exercise - physiology
Female
Humans
Leisure Activities
Male
Middle Aged
Risk Factors
Cognitive decline
Physical activity
Epidemiology
Cohort study
Dementia
ISSN:1552-5279, 1552-5279
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Zusammenfassung:We tested the hypotheses that higher levels of and persistence of midlife leisure-time physical activity (LTPA) are associated long-term with lower cognitive decline and less incident dementia. A total of 10,705 participants (mean age: 60 years) had LTPA (no, low, middle, or high) measured in 1987-1989 and 1993-1995. LTPA was assessed in relation to incident dementia and 14-year change in general cognitive performance. Over a median follow-up of 17.4 years, 1063 dementia cases were observed. Compared with no LTPA, high LTPA in midlife was associated with lower incidence of dementia (hazard ratio [95% confidence interval], 0.71 [0.61, 0.86]) and lower declines in general cognitive performance (-0.07 standard deviation difference [-0.12 to -0.04]). These associations were stronger when measured against persistence of midlife LTPA over 6 years. LTPA is a readily modifiable factor associated inversely with long-term dementia incidence and cognitive decline.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1552-5279
1552-5279
DOI:10.1016/j.jalz.2018.08.008