Effects of Altering Levothyroxine (L-T4) Doses on Quality of Life, Mood, and Cognition in L-T4 Treated Subjects

Abstract Background The brain is a critical target organ for thyroid hormone, but it is unclear whether variations in thyroid function within and near the reference range affect quality of life, mood, or cognition. Methods A total of 138 subjects with levothyroxine (L-T4)-treated hypothyroidism and...

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Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism Vol. 103; no. 5; pp. 1997 - 2008
Main Authors:	Samuels, Mary H, Kolobova, Irina, Niederhausen, Meike, Janowsky, Jeri S, Schuff, Kathryn G
Format:	Journal Article
Language:	English
Published:	Washington, DC Endocrine Society 01.05.2018 Copyright Oxford University Press Oxford University Press
Subjects:	Adult Affect - drug effects Aged Clinical s Clinical trials Cognition Cognition & reasoning Cognition - drug effects Dose-Response Relationship, Drug Emotional behavior Executive function Female Hormone Replacement Therapy - methods Humans Hypothyroidism Hypothyroidism - blood Hypothyroidism - drug therapy Hypothyroidism - psychology Lability Male Memory Middle Aged Mood Motivation Quality of life Quality of Life - psychology Thyroid Thyroid gland Thyroid-stimulating hormone Thyrotropin - blood Thyroxine Thyroxine - administration & dosage Treatment Outcome
ISSN:	0021-972X, 1945-7197, 1945-7197
Online Access:	Get full text
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