Patterns of Multiple Organ Dysfunction and Renal Recovery in Critically Ill Children and Young Adults Receiving Continuous Renal Replacement Therapy

OBJECTIVES: Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal replacement therapy (CRRT) is the modality of choice for AKI-D. Mid-term outcomes of pediatric AKI-D supported with CRRT are unknown. We aimed to...

Full description

Saved in:

Bibliographic Details
Published in:	Critical care explorations Vol. 6; no. 5; p. e1084
Main Authors:	Thadani, Sameer, Fuhrman, Dana, Hanson, Claire, Park, Hyun Jung, Angelo, Joseph, Srivaths, Poyyapakkam, Typpo, Katri, Bell, Michael J., Gist, Katja M., Carcillo, Joseph, Akcan-Arikan, Ayse
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 06.05.2024 Wolters Kluwer
Subjects:	Acute Kidney Injury - physiopathology Acute Kidney Injury - therapy Adolescent Adult Child Child, Preschool Cohort Studies Continuous Renal Replacement Therapy - methods Critical Illness - therapy Female Humans Infant Male Multiple Organ Failure - etiology Multiple Organ Failure - physiopathology Multiple Organ Failure - therapy Observational Study Organ Dysfunction Scores Renal Replacement Therapy - methods Retrospective Studies Young Adult progressive multiple organ dysfunction continuous renal replacement therapy outcomes pediatrics
ISSN:	2639-8028, 2639-8028
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	OBJECTIVES: Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal replacement therapy (CRRT) is the modality of choice for AKI-D. Mid-term outcomes of pediatric AKI-D supported with CRRT are unknown. We aimed to describe the pattern and impact of organ dysfunction on renal outcomes in critically ill children and young adults with AKI-D. DESIGN: Retrospective cohort. SETTING: Two large quarternary care pediatric hospitals. PATIENTS: Patients 26 y old or younger who received CRRT from 2014 to 2020, excluding patients with chronic kidney disease. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Organ dysfunction was assessed using the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. MODS was defined as greater than or equal to two organ dysfunctions. The primary outcome was major adverse kidney events at 30 days (MAKE30) (decrease in estimated glomerular filtration rate greater than or equal to 25% from baseline, need for renal replacement therapy, and death). Three hundred seventy-three patients, 50% female, with a median age of 84 mo (interquartile range [IQR] 16-172) were analyzed. PELOD-2 increased from 6 (IQR 3-9) to 9 (IQR 7-12) between ICU admission and CRRT initiation. Ninety-seven percent of patients developed MODS at CRRT start and 266 patients (71%) had MAKE30. Acute kidney injury (adjusted odds ratio [aOR] 3.55 [IQR 2.13-5.90]), neurologic (aOR 2.07 [IQR 1.15-3.74]), hematologic/oncologic dysfunction (aOR 2.27 [IQR 1.32-3.91]) at CRRT start, and progressive MODS (aOR 1.11 [IQR 1.03-1.19]) were independently associated with MAKE30. CONCLUSIONS: Ninety percent of critically ill children and young adults with AKI-D develop MODS by the start of CRRT. Lack of renal recovery is associated with specific extrarenal organ dysfunction and progressive multiple organ dysfunction. Currently available extrarenal organ support strategies, such as therapeutic plasma exchange lung-protective ventilation, and other modifiable risk factors, should be incorporated into clinical trial design when investigating renal recovery.
AbstractList	Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal replacement therapy (CRRT) is the modality of choice for AKI-D. Mid-term outcomes of pediatric AKI-D supported with CRRT are unknown. We aimed to describe the pattern and impact of organ dysfunction on renal outcomes in critically ill children and young adults with AKI-D.OBJECTIVESAcute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal replacement therapy (CRRT) is the modality of choice for AKI-D. Mid-term outcomes of pediatric AKI-D supported with CRRT are unknown. We aimed to describe the pattern and impact of organ dysfunction on renal outcomes in critically ill children and young adults with AKI-D.Retrospective cohort.DESIGNRetrospective cohort.Two large quarternary care pediatric hospitals.SETTINGTwo large quarternary care pediatric hospitals.Patients 26 y old or younger who received CRRT from 2014 to 2020, excluding patients with chronic kidney disease.PATIENTSPatients 26 y old or younger who received CRRT from 2014 to 2020, excluding patients with chronic kidney disease.None.INTERVENTIONSNone.Organ dysfunction was assessed using the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. MODS was defined as greater than or equal to two organ dysfunctions. The primary outcome was major adverse kidney events at 30 days (MAKE30) (decrease in estimated glomerular filtration rate greater than or equal to 25% from baseline, need for renal replacement therapy, and death). Three hundred seventy-three patients, 50% female, with a median age of 84 mo (interquartile range [IQR] 16-172) were analyzed. PELOD-2 increased from 6 (IQR 3-9) to 9 (IQR 7-12) between ICU admission and CRRT initiation. Ninety-seven percent of patients developed MODS at CRRT start and 266 patients (71%) had MAKE30. Acute kidney injury (adjusted odds ratio [aOR] 3.55 [IQR 2.13-5.90]), neurologic (aOR 2.07 [IQR 1.15-3.74]), hematologic/oncologic dysfunction (aOR 2.27 [IQR 1.32-3.91]) at CRRT start, and progressive MODS (aOR 1.11 [IQR 1.03-1.19]) were independently associated with MAKE30.MEASUREMENTS AND MAIN RESULTSOrgan dysfunction was assessed using the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. MODS was defined as greater than or equal to two organ dysfunctions. The primary outcome was major adverse kidney events at 30 days (MAKE30) (decrease in estimated glomerular filtration rate greater than or equal to 25% from baseline, need for renal replacement therapy, and death). Three hundred seventy-three patients, 50% female, with a median age of 84 mo (interquartile range [IQR] 16-172) were analyzed. PELOD-2 increased from 6 (IQR 3-9) to 9 (IQR 7-12) between ICU admission and CRRT initiation. Ninety-seven percent of patients developed MODS at CRRT start and 266 patients (71%) had MAKE30. Acute kidney injury (adjusted odds ratio [aOR] 3.55 [IQR 2.13-5.90]), neurologic (aOR 2.07 [IQR 1.15-3.74]), hematologic/oncologic dysfunction (aOR 2.27 [IQR 1.32-3.91]) at CRRT start, and progressive MODS (aOR 1.11 [IQR 1.03-1.19]) were independently associated with MAKE30.Ninety percent of critically ill children and young adults with AKI-D develop MODS by the start of CRRT. Lack of renal recovery is associated with specific extrarenal organ dysfunction and progressive multiple organ dysfunction. Currently available extrarenal organ support strategies, such as therapeutic plasma exchange lung-protective ventilation, and other modifiable risk factors, should be incorporated into clinical trial design when investigating renal recovery.CONCLUSIONSNinety percent of critically ill children and young adults with AKI-D develop MODS by the start of CRRT. Lack of renal recovery is associated with specific extrarenal organ dysfunction and progressive multiple organ dysfunction. Currently available extrarenal organ support strategies, such as therapeutic plasma exchange lung-protective ventilation, and other modifiable risk factors, should be incorporated into clinical trial design when investigating renal recovery. OBJECTIVES: Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal replacement therapy (CRRT) is the modality of choice for AKI-D. Mid-term outcomes of pediatric AKI-D supported with CRRT are unknown. We aimed to describe the pattern and impact of organ dysfunction on renal outcomes in critically ill children and young adults with AKI-D. DESIGN: Retrospective cohort. SETTING: Two large quarternary care pediatric hospitals. PATIENTS: Patients 26 y old or younger who received CRRT from 2014 to 2020, excluding patients with chronic kidney disease. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Organ dysfunction was assessed using the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. MODS was defined as greater than or equal to two organ dysfunctions. The primary outcome was major adverse kidney events at 30 days (MAKE30) (decrease in estimated glomerular filtration rate greater than or equal to 25% from baseline, need for renal replacement therapy, and death). Three hundred seventy-three patients, 50% female, with a median age of 84 mo (interquartile range [IQR] 16-172) were analyzed. PELOD-2 increased from 6 (IQR 3-9) to 9 (IQR 7-12) between ICU admission and CRRT initiation. Ninety-seven percent of patients developed MODS at CRRT start and 266 patients (71%) had MAKE30. Acute kidney injury (adjusted odds ratio [aOR] 3.55 [IQR 2.13-5.90]), neurologic (aOR 2.07 [IQR 1.15-3.74]), hematologic/oncologic dysfunction (aOR 2.27 [IQR 1.32-3.91]) at CRRT start, and progressive MODS (aOR 1.11 [IQR 1.03-1.19]) were independently associated with MAKE30. CONCLUSIONS: Ninety percent of critically ill children and young adults with AKI-D develop MODS by the start of CRRT. Lack of renal recovery is associated with specific extrarenal organ dysfunction and progressive multiple organ dysfunction. Currently available extrarenal organ support strategies, such as therapeutic plasma exchange lung-protective ventilation, and other modifiable risk factors, should be incorporated into clinical trial design when investigating renal recovery. OBJECTIVES:. Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal replacement therapy (CRRT) is the modality of choice for AKI-D. Mid-term outcomes of pediatric AKI-D supported with CRRT are unknown. We aimed to describe the pattern and impact of organ dysfunction on renal outcomes in critically ill children and young adults with AKI-D. DESIGN:. Retrospective cohort. SETTING:. Two large quarternary care pediatric hospitals. PATIENTS:. Patients 26 y old or younger who received CRRT from 2014 to 2020, excluding patients with chronic kidney disease. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. Organ dysfunction was assessed using the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. MODS was defined as greater than or equal to two organ dysfunctions. The primary outcome was major adverse kidney events at 30 days (MAKE30) (decrease in estimated glomerular filtration rate greater than or equal to 25% from baseline, need for renal replacement therapy, and death). Three hundred seventy-three patients, 50% female, with a median age of 84 mo (interquartile range [IQR] 16–172) were analyzed. PELOD-2 increased from 6 (IQR 3–9) to 9 (IQR 7–12) between ICU admission and CRRT initiation. Ninety-seven percent of patients developed MODS at CRRT start and 266 patients (71%) had MAKE30. Acute kidney injury (adjusted odds ratio [aOR] 3.55 [IQR 2.13–5.90]), neurologic (aOR 2.07 [IQR 1.15–3.74]), hematologic/oncologic dysfunction (aOR 2.27 [IQR 1.32–3.91]) at CRRT start, and progressive MODS (aOR 1.11 [IQR 1.03–1.19]) were independently associated with MAKE30. CONCLUSIONS:. Ninety percent of critically ill children and young adults with AKI-D develop MODS by the start of CRRT. Lack of renal recovery is associated with specific extrarenal organ dysfunction and progressive multiple organ dysfunction. Currently available extrarenal organ support strategies, such as therapeutic plasma exchange lung-protective ventilation, and other modifiable risk factors, should be incorporated into clinical trial design when investigating renal recovery. Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal replacement therapy (CRRT) is the modality of choice for AKI-D. Mid-term outcomes of pediatric AKI-D supported with CRRT are unknown. We aimed to describe the pattern and impact of organ dysfunction on renal outcomes in critically ill children and young adults with AKI-D. Retrospective cohort. Two large quarternary care pediatric hospitals. Patients 26 y old or younger who received CRRT from 2014 to 2020, excluding patients with chronic kidney disease. None. Organ dysfunction was assessed using the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. MODS was defined as greater than or equal to two organ dysfunctions. The primary outcome was major adverse kidney events at 30 days (MAKE30) (decrease in estimated glomerular filtration rate greater than or equal to 25% from baseline, need for renal replacement therapy, and death). Three hundred seventy-three patients, 50% female, with a median age of 84 mo (interquartile range [IQR] 16-172) were analyzed. PELOD-2 increased from 6 (IQR 3-9) to 9 (IQR 7-12) between ICU admission and CRRT initiation. Ninety-seven percent of patients developed MODS at CRRT start and 266 patients (71%) had MAKE30. Acute kidney injury (adjusted odds ratio [aOR] 3.55 [IQR 2.13-5.90]), neurologic (aOR 2.07 [IQR 1.15-3.74]), hematologic/oncologic dysfunction (aOR 2.27 [IQR 1.32-3.91]) at CRRT start, and progressive MODS (aOR 1.11 [IQR 1.03-1.19]) were independently associated with MAKE30. Ninety percent of critically ill children and young adults with AKI-D develop MODS by the start of CRRT. Lack of renal recovery is associated with specific extrarenal organ dysfunction and progressive multiple organ dysfunction. Currently available extrarenal organ support strategies, such as therapeutic plasma exchange lung-protective ventilation, and other modifiable risk factors, should be incorporated into clinical trial design when investigating renal recovery.
Author	Hanson, Claire Typpo, Katri Gist, Katja M. Fuhrman, Dana Srivaths, Poyyapakkam Bell, Michael J. Carcillo, Joseph Akcan-Arikan, Ayse Angelo, Joseph Thadani, Sameer Park, Hyun Jung
Author_xml	– sequence: 1 givenname: Sameer surname: Thadani fullname: Thadani, Sameer organization: Division of Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX – sequence: 2 givenname: Dana surname: Fuhrman fullname: Fuhrman, Dana organization: Division of Nephrology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA – sequence: 3 givenname: Claire surname: Hanson fullname: Hanson, Claire organization: Division of Pediatric Critical Care Medicine, Department of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA – sequence: 4 givenname: Hyun Jung surname: Park fullname: Park, Hyun Jung organization: Department of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA – sequence: 5 givenname: Joseph surname: Angelo fullname: Angelo, Joseph organization: Division of Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX – sequence: 6 givenname: Poyyapakkam surname: Srivaths fullname: Srivaths, Poyyapakkam organization: Division of Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX – sequence: 7 givenname: Katri surname: Typpo fullname: Typpo, Katri organization: Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX – sequence: 8 givenname: Michael J. surname: Bell fullname: Bell, Michael J. organization: Department of Critical Care Medicine, Children's National Hospital, Washington, DC – sequence: 9 givenname: Katja M. surname: Gist fullname: Gist, Katja M. organization: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH – sequence: 10 givenname: Joseph surname: Carcillo fullname: Carcillo, Joseph organization: Division of Nephrology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA – sequence: 11 givenname: Ayse surname: Akcan-Arikan fullname: Akcan-Arikan, Ayse organization: Division of Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/38709083$$D View this record in MEDLINE/PubMed
BookMark	eNqFkkFvFCEUxyemxtbab2AMRy9bgYGF8WKaseomNTWmHjwRBt7sUlnYwsw2-z38wLJu22x7UA5AHv__7-Xx3svqIMQAVfWa4FOCG_Gubc9P8d4iWLJn1RGd1s1EYioP9u6H1UnO10VECSdcsBfVYS0FbrCsj6rf3_QwQAoZxR59Hf3gVh7QZZrrgD5ucj8GM7gYkA4WfYegfdlNXEPaIBdQm9zgjPZ-g2beo3bhvE2wU_-MY5ijM1uYeWsCt3Yl0MYwuDDGMT_wVl4bWEIY0NUCkl5tXlXPe-0znNydx9WPT-dX7ZfJxeXnWXt2MTGcMjYx1ILhWPa4oZpIUXNGiWwY500j5BREZxsriLZgQdPG1tIUY99JTqcd7Vh9XM12XBv1tVolt9Rpo6J26m8gprnSqRToQXUSs-KSXHSECWgkaCunrKNM09oyXVgfdqzV2C3BmlJO0v4R9PFLcAs1j2tFCBa8YbQQ3t4RUrwZIQ9q6bIB73WA8l2qxpwwKgjZSt_sJ3vIct_XIni_E5gUc07QK-MGve1kye28Ilht50iVOVJP56iY2RPzPf8_Nrmz3UZfRir_8uMtJLUA7YfFv61_ACfK3M4
CitedBy_id	crossref_primary_10_1097_CCE_0000000000001188
Cites_doi	10.2215/CJN.08300813 10.1038/sj.ki.5002231 10.1542/hpeds.2017-0215 10.1159/000363725 10.1097/PCC.0000000000001166 10.1097/PCC.0000000000002044 10.1056/NEJMoa1611391 10.1681/ASN.2020111665 10.1186/s13054-015-1054-y 10.1097/PCC.0000000000001047 10.1007/s00467-010-1508-z 10.1053/j.ajkd.2004.09.028 10.1097/CCE.0000000000000614 10.1186/s12882-020-02076-1 10.1038/nrneph.2017.2 10.1097/CCE.0000000000000891 10.1007/s00134-019-05919-0 10.1007/s00467-022-05579-1 10.1183/09031936.98.12030653 10.1053/j.ajkd.2018.03.028 10.2215/CJN.04240415 10.1038/s41569-020-00469-1 10.1542/peds.2006-2353 10.1001/jamapediatrics.2016.1532 10.1542/peds.58.2.259 10.1097/01.CCM.0000165808.30416.EF 10.3109/0886022X.2015.1057799 10.1097/CCM.0b013e31828a2bbd 10.1159/000447543 10.1007/s00467-013-2741-z 10.1177/2054358119880188
ContentType	Journal Article
Copyright	Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. 2024
Copyright_xml	– notice: Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. – notice: Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. 2024
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA
DOI	10.1097/CCE.0000000000001084
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
EISSN	2639-8028
ExternalDocumentID	oai_doaj_org_article_b80426b857b147e98ead864b24a23d4a PMC11075942 38709083 10_1097_CCE_0000000000001084 CCE-D-24-00013
Genre	research-article Journal Article
GroupedDBID	0R~ 53G AAAAV AAHPQ AAIQE AASCR ABASU ABDIG ABVCZ ABZZY ACILI ACXJB ADGGA ADHPY ADPDF AFBFQ AFDTB AHQNM AINUH AJCLO AJNWD AJZMW AKCTQ ALKUP ALMA_UNASSIGNED_HOLDINGS AMJPA AMKUR AMNEI AOHHW AOQMC DIWNM EBS EEVPB FCALG GNXGY GQDEL GROUPED_DOAJ HLJTE IKREB M~E OK1 OPUJH OVD OVDNE RLZ RPM TEORI TSPGW AAYXX ACBKD ADKSD CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM
ID	FETCH-LOGICAL-c5244-c2dec508f092a187354218945599786e7bd9d71adedea29d38cc52fb8526b2b43
IEDL.DBID	DOA
ISICitedReferencesCount	2
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001275967300004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2639-8028
IngestDate	Tue Oct 14 19:08:59 EDT 2025 Tue Nov 04 02:05:33 EST 2025 Sun Nov 09 13:03:36 EST 2025 Thu Apr 03 07:03:44 EDT 2025 Sat Nov 29 05:58:47 EST 2025 Tue Nov 18 22:13:36 EST 2025 Wed Apr 16 02:29:10 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	5
Keywords	progressive multiple organ dysfunction continuous renal replacement therapy outcomes pediatrics
Language	English
License	http://creativecommons.org/licenses/by-nc-nd/4.0 Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c5244-c2dec508f092a187354218945599786e7bd9d71adedea29d38cc52fb8526b2b43
Notes	Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (http://journals.lww.com/ccejournal). Data were collected from patients admitted at Texas Children's Hospital and the University of Pittsburgh Medical Center Children's Hospital of Pittsburgh. The authors have not disclosed that they do not have any potential conflicts of interest. For information regarding this article, E-mail: sameer.thadani@bcm.edu ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://doaj.org/article/b80426b857b147e98ead864b24a23d4a
PMID	38709083
PQID	3051427112
PQPubID	23479
ParticipantIDs	doaj_primary_oai_doaj_org_article_b80426b857b147e98ead864b24a23d4a pubmedcentral_primary_oai_pubmedcentral_nih_gov_11075942 proquest_miscellaneous_3051427112 pubmed_primary_38709083 crossref_citationtrail_10_1097_CCE_0000000000001084 crossref_primary_10_1097_CCE_0000000000001084 wolterskluwer_health_10_1097_CCE_0000000000001084
PublicationCentury	2000
PublicationDate	2024-May-06
PublicationDateYYYYMMDD	2024-05-06
PublicationDate_xml	– month: 05 year: 2024 text: 2024-May-06 day: 06
PublicationDecade	2020
PublicationPlace	Hagerstown, MD
PublicationPlace_xml	– name: Hagerstown, MD – name: United States
PublicationTitle	Critical care explorations
PublicationTitleAlternate	Crit Care Explor
PublicationYear	2024
Publisher	Lippincott Williams & Wilkins Wolters Kluwer
Publisher_xml	– name: Lippincott Williams & Wilkins – name: Wolters Kluwer
References	Ferreira, Johnson (R28) 2015; 37 Odetola, Gebremariam, Freed (R4) 2007; 119 Hsu, Symons (R2) 2010; 25 Guru, Singh, Akhoundi (R29) 2016; 133 Frisby-Zedan, Barhight, Keswani (R13) 2022; 38 Hui-Stickle, Brewer, Goldstein (R14) 2005; 45 Hessey, Perreault, Dorais (R21) 2019; 6 Fuhrman, Thadani, Hanson (R31) 2023; 5 Robinson, Jeyakumar, Luo (R12) 2021; 32 Fathima, Kashif, Janapala (R15) 2019; 11 Hessey, Ali, Dorais (R16) 2017; 18 Lee, Cozzi, Bush (R23) 2018; 72 Sharkey, Mulloy, O'Neill (R26) 1998; 12 Leteurtre, Duhamel, Deken (R3) 2015; 19 Jhang, Kim, Ha (R6) 2014; 29 Typpo, Watson, Bennett (R24) 2019; 20 Greenberg, Zappitelli, Devarajan (R18) 2016; 170 Schwartz, Haycock, Edelmann (R11) 1976; 58 Chawla, Bellomo, Bihorac (R32) 2017; 13 Darmon, Clec'h, Adrie (R25) 2014; 9 Akcan-Arikan, Zappitelli, Loftis (R8) 2007; 71 Batte, Starr, Schwaderer (R9) 2020; 21 Cooper, Claes, Goldstein (R17) 2016; 11 Hessey, Morissette, Lacroix (R20) 2018; 8 Hoste, Bihorac, Al-Khafaji (R22) 2020; 46 Watson, Crow, Hartman (R5) 2017; 18 Gu, Tyagi, Jain (R30) 2021; 18 Billings, Shaw (R7) 2014; 127 Kuiper, Groeneveld, Slutsky (R27) 2005; 33 Leteurtre, Duhamel, Salleron (R10) 2013; 41 Kaddourah, Basu, Bagshaw (R1) 2017; 376 Ulrich, Hessey, Perreault (R19) 2022; 4 Hessey (R16-20240806) 2017; 18 Guru (R29-20240806) 2016; 133 Fuhrman (R31-20240806) 2023; 5 Schwartz (R11-20240806) 1976; 58 Kaddourah (R1-20240806) 2017; 376 Leteurtre (R3-20240806) 2015; 19 Greenberg (R18-20240806) 2016; 170 Billings (R7-20240806) 2014; 127 Watson (R5-20240806) 2017; 18 Ulrich (R19-20240806) 2022; 4 Robinson (R12-20240806) 2021; 32 Hsu (R2-20240806) 2010; 25 Cooper (R17-20240806) 2016; 11 Jhang (R6-20240806) 2014; 29 Akcan-Arikan (R8-20240806) 2007; 71 Frisby-Zedan (R13-20240806) 2022; 38 Hoste (R22-20240806) 2020; 46 Typpo (R24-20240806) 2019; 20 Hui-Stickle (R14-20240806) 2005; 45 Hessey (R20-20240806) 2018; 8 Ferreira (R28-20240806) 2015; 37 Odetola (R4-20240806) 2007; 119 Sharkey (R26-20240806) 1998; 12 Kuiper (R27-20240806) 2005; 33 Gu (R30-20240806) 2021; 18 Fathima (R15-20240806) 2019; 11 Leteurtre (R10-20240806) 2013; 41 Hessey (R21-20240806) 2019; 6 Lee (R23-20240806) 2018; 72 Chawla (R32-20240806) 2017; 13 Darmon (R25-20240806) 2014; 9 Batte (R9-20240806) 2020; 21
References_xml	– volume: 29 start-page: 1089 year: 2014 end-page: 1095 ident: R6 article-title: Extrarenal sequential organ failure assessment score as an outcome predictor of critically ill children on continuous renal replacement therapy. publication-title: Pediatr Nephrol – volume: 11 start-page: e5558 year: 2019 ident: R15 article-title: Single-best choice between intermittent versus continuous renal replacement therapy: A review. publication-title: Cureus – volume: 33 start-page: 1408 year: 2005 end-page: 1415 ident: R27 article-title: Mechanical ventilation and acute renal failure. publication-title: Crit Care Med – volume: 20 start-page: 914 year: 2019 end-page: 922 ident: R24 article-title: Outcomes of day 1 multiple organ dysfunction syndrome in the PICU. publication-title: Pediatr Crit Care Med – volume: 12 start-page: 653 year: 1998 end-page: 657 ident: R26 article-title: Acute effects of hypoxaemia, hyperoxaemia and hypercapnia on renal blood flow in normal and renal transplant subjects. publication-title: Eur Respir J – volume: 19 start-page: 324 year: 2015 ident: R3 article-title: Daily estimation of the severity of organ dysfunctions in critically ill children by using the PELOD-2 score. publication-title: Crit Care – volume: 32 start-page: 2005 year: 2021 end-page: 2019 ident: R12 article-title: Long-term kidney outcomes following childhood acute kidney injury receiving dialysis: A population-based cohort study. publication-title: J Am Soc Nephrol – volume: 170 start-page: 1071 year: 2016 end-page: 1078 ident: R18 article-title: Kidney outcomes 5 years after pediatric cardiac surgery: The TRIBE-AKI study. publication-title: JAMA Pediatr – volume: 72 start-page: 846 year: 2018 end-page: 856 ident: R23 article-title: Distant organ dysfunction in acute kidney injury: A review. publication-title: Am J Kidney Dis – volume: 18 start-page: 733 year: 2017 end-page: 740 ident: R16 article-title: Renal function follow-up and renal recovery after acute kidney injury in critically ill children. publication-title: Pediatr Crit Care Med – volume: 58 start-page: 259 year: 1976 end-page: 263 ident: R11 article-title: A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. publication-title: Pediatrics – volume: 4 start-page: e0614 year: 2022 ident: R19 article-title: Association of nonrecovery of kidney function after pediatric acute kidney injury with 5-year kidney and nonkidney outcomes. publication-title: Crit Care Explor – volume: 13 start-page: 241 year: 2017 end-page: 257 ident: R32 article-title: Acute kidney disease and renal recovery: Consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup. publication-title: Nat Rev Nephrol – volume: 9 start-page: 1347 year: 2014 end-page: 1353 ident: R25 article-title: Acute respiratory distress syndrome and risk of AKI among critically ill patients. publication-title: Clin J Am Soc Nephrol – volume: 41 start-page: 1761 year: 2013 end-page: 1773 ident: R10 article-title: PELOD-2: An update of the PEdiatric logistic organ dysfunction score. publication-title: Crit Care Med – volume: 8 start-page: 260 year: 2018 end-page: 268 ident: R20 article-title: Long-term mortality after acute kidney injury in the pediatric ICU. publication-title: Hosp Pediatr – volume: 133 start-page: 175 year: 2016 end-page: 182 ident: R29 article-title: Association of thrombocytopenia and mortality in critically ill patients on continuous renal replacement therapy. publication-title: Nephron – volume: 45 start-page: 96 year: 2005 end-page: 101 ident: R14 article-title: Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001. publication-title: Am J Kidney Dis – volume: 71 start-page: 1028 year: 2007 end-page: 1035 ident: R8 article-title: Modified RIFLE criteria in critically ill children with acute kidney injury. publication-title: Kidney Int – volume: 46 start-page: 943 year: 2020 end-page: 953 ident: R22 article-title: Identification and validation of biomarkers of persistent acute kidney injury: The RUBY study. publication-title: Intensive Care Med – volume: 18 start-page: 194 year: 2021 end-page: 209 ident: R30 article-title: Thrombocytopathy and endotheliopathy: Crucial contributors to COVID-19 thromboinflammation. publication-title: Nat Rev Cardiol – volume: 376 start-page: 11 year: 2017 end-page: 20 ident: R1 article-title: Epidemiology of acute kidney injury in critically ill children and young adults. publication-title: N Engl J Med – volume: 25 start-page: 2401 year: 2010 end-page: 2412 ident: R2 article-title: Acute kidney injury: Can we improve prognosis? publication-title: Pediatr Nephrol – volume: 5 start-page: e0891 year: 2023 ident: R31 article-title: Therapeutic plasma exchange is associated with improved major adverse kidney events in children and young adults with thrombocytopenia at the time of continuous kidney replacement therapy initiation. publication-title: Crit Care Explor – volume: 38 start-page: 565 year: 2022 end-page: 572 ident: R13 article-title: Long-term kidney outcomes in children following continuous kidney replacement therapy. publication-title: Pediatr Nephrol – volume: 18 start-page: S4 year: 2017 end-page: S16 ident: R5 article-title: Epidemiology and outcomes of pediatric multiple organ dysfunction syndrome. publication-title: Pediatr Crit Care Med – volume: 6 start-page: 205435811988018 year: 2019 ident: R21 article-title: Acute kidney injury in critically ill children and subsequent chronic kidney disease. publication-title: Can J Kidney Health Dis – volume: 11 start-page: 21 year: 2016 end-page: 29 ident: R17 article-title: Follow-up renal assessment of injury long-term after acute kidney injury (FRAIL-AKI). publication-title: Clin J Am Soc Nephrol – volume: 119 start-page: 487 year: 2007 end-page: 494 ident: R4 article-title: Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis. publication-title: Pediatrics – volume: 127 start-page: 89 year: 2014 end-page: 93 ident: R7 article-title: Clinical trial endpoints in acute kidney injury. publication-title: Nephron Clin Pract – volume: 21 start-page: 417 year: 2020 ident: R9 article-title: Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: A prospective cohort study. publication-title: BMC Nephrol – volume: 37 start-page: 1232 year: 2015 end-page: 1236 ident: R28 article-title: The incidence of thrombocytopenia associated with continuous renal replacement therapy in critically ill patients. publication-title: Ren Fail – volume: 9 start-page: 1347 year: 2014 ident: R25-20240806 article-title: Acute respiratory distress syndrome and risk of AKI among critically ill patients. publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.08300813 – volume: 71 start-page: 1028 year: 2007 ident: R8-20240806 article-title: Modified RIFLE criteria in critically ill children with acute kidney injury. publication-title: Kidney Int doi: 10.1038/sj.ki.5002231 – volume: 8 start-page: 260 year: 2018 ident: R20-20240806 article-title: Long-term mortality after acute kidney injury in the pediatric ICU. publication-title: Hosp Pediatr doi: 10.1542/hpeds.2017-0215 – volume: 127 start-page: 89 year: 2014 ident: R7-20240806 article-title: Clinical trial endpoints in acute kidney injury. publication-title: Nephron Clin Pract doi: 10.1159/000363725 – volume: 18 start-page: 733 year: 2017 ident: R16-20240806 article-title: Renal function follow-up and renal recovery after acute kidney injury in critically ill children. publication-title: Pediatr Crit Care Med doi: 10.1097/PCC.0000000000001166 – volume: 20 start-page: 914 year: 2019 ident: R24-20240806 article-title: Outcomes of day 1 multiple organ dysfunction syndrome in the PICU. publication-title: Pediatr Crit Care Med doi: 10.1097/PCC.0000000000002044 – volume: 376 start-page: 11 year: 2017 ident: R1-20240806 article-title: Epidemiology of acute kidney injury in critically ill children and young adults. publication-title: N Engl J Med doi: 10.1056/NEJMoa1611391 – volume: 32 start-page: 2005 year: 2021 ident: R12-20240806 article-title: Long-term kidney outcomes following childhood acute kidney injury receiving dialysis: A population-based cohort study. publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2020111665 – volume: 19 start-page: 324 year: 2015 ident: R3-20240806 article-title: Daily estimation of the severity of organ dysfunctions in critically ill children by using the PELOD-2 score. publication-title: Crit Care doi: 10.1186/s13054-015-1054-y – volume: 18 start-page: S4 year: 2017 ident: R5-20240806 article-title: Epidemiology and outcomes of pediatric multiple organ dysfunction syndrome. publication-title: Pediatr Crit Care Med doi: 10.1097/PCC.0000000000001047 – volume: 25 start-page: 2401 year: 2010 ident: R2-20240806 article-title: Acute kidney injury: Can we improve prognosis? publication-title: Pediatr Nephrol doi: 10.1007/s00467-010-1508-z – volume: 45 start-page: 96 year: 2005 ident: R14-20240806 article-title: Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001. publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2004.09.028 – volume: 4 start-page: e0614 year: 2022 ident: R19-20240806 article-title: Association of nonrecovery of kidney function after pediatric acute kidney injury with 5-year kidney and nonkidney outcomes. publication-title: Crit Care Explor doi: 10.1097/CCE.0000000000000614 – volume: 21 start-page: 417 year: 2020 ident: R9-20240806 article-title: Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: A prospective cohort study. publication-title: BMC Nephrol doi: 10.1186/s12882-020-02076-1 – volume: 13 start-page: 241 year: 2017 ident: R32-20240806 article-title: Acute kidney disease and renal recovery: Consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup. publication-title: Nat Rev Nephrol doi: 10.1038/nrneph.2017.2 – volume: 5 start-page: e0891 year: 2023 ident: R31-20240806 article-title: Therapeutic plasma exchange is associated with improved major adverse kidney events in children and young adults with thrombocytopenia at the time of continuous kidney replacement therapy initiation. publication-title: Crit Care Explor doi: 10.1097/CCE.0000000000000891 – volume: 46 start-page: 943 year: 2020 ident: R22-20240806 article-title: Identification and validation of biomarkers of persistent acute kidney injury: The RUBY study. publication-title: Intensive Care Med doi: 10.1007/s00134-019-05919-0 – volume: 38 start-page: 565 year: 2022 ident: R13-20240806 article-title: Long-term kidney outcomes in children following continuous kidney replacement therapy. publication-title: Pediatr Nephrol doi: 10.1007/s00467-022-05579-1 – volume: 12 start-page: 653 year: 1998 ident: R26-20240806 article-title: Acute effects of hypoxaemia, hyperoxaemia and hypercapnia on renal blood flow in normal and renal transplant subjects. publication-title: Eur Respir J doi: 10.1183/09031936.98.12030653 – volume: 72 start-page: 846 year: 2018 ident: R23-20240806 article-title: Distant organ dysfunction in acute kidney injury: A review. publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2018.03.028 – volume: 11 start-page: 21 year: 2016 ident: R17-20240806 article-title: Follow-up renal assessment of injury long-term after acute kidney injury (FRAIL-AKI). publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.04240415 – volume: 18 start-page: 194 year: 2021 ident: R30-20240806 article-title: Thrombocytopathy and endotheliopathy: Crucial contributors to COVID-19 thromboinflammation. publication-title: Nat Rev Cardiol doi: 10.1038/s41569-020-00469-1 – volume: 119 start-page: 487 year: 2007 ident: R4-20240806 article-title: Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis. publication-title: Pediatrics doi: 10.1542/peds.2006-2353 – volume: 11 start-page: e5558 year: 2019 ident: R15-20240806 article-title: Single-best choice between intermittent versus continuous renal replacement therapy: A review. publication-title: Cureus – volume: 170 start-page: 1071 year: 2016 ident: R18-20240806 article-title: Kidney outcomes 5 years after pediatric cardiac surgery: The TRIBE-AKI study. publication-title: JAMA Pediatr doi: 10.1001/jamapediatrics.2016.1532 – volume: 58 start-page: 259 year: 1976 ident: R11-20240806 article-title: A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. publication-title: Pediatrics doi: 10.1542/peds.58.2.259 – volume: 33 start-page: 1408 year: 2005 ident: R27-20240806 article-title: Mechanical ventilation and acute renal failure. publication-title: Crit Care Med doi: 10.1097/01.CCM.0000165808.30416.EF – volume: 37 start-page: 1232 year: 2015 ident: R28-20240806 article-title: The incidence of thrombocytopenia associated with continuous renal replacement therapy in critically ill patients. publication-title: Ren Fail doi: 10.3109/0886022X.2015.1057799 – volume: 41 start-page: 1761 year: 2013 ident: R10-20240806 article-title: PELOD-2: An update of the PEdiatric logistic organ dysfunction score. publication-title: Crit Care Med doi: 10.1097/CCM.0b013e31828a2bbd – volume: 133 start-page: 175 year: 2016 ident: R29-20240806 article-title: Association of thrombocytopenia and mortality in critically ill patients on continuous renal replacement therapy. publication-title: Nephron doi: 10.1159/000447543 – volume: 29 start-page: 1089 year: 2014 ident: R6-20240806 article-title: Extrarenal sequential organ failure assessment score as an outcome predictor of critically ill children on continuous renal replacement therapy. publication-title: Pediatr Nephrol doi: 10.1007/s00467-013-2741-z – volume: 6 start-page: 205435811988018 year: 2019 ident: R21-20240806 article-title: Acute kidney injury in critically ill children and subsequent chronic kidney disease. publication-title: Can J Kidney Health Dis doi: 10.1177/2054358119880188
SSID	ssj0002151574
Score	2.2694504
Snippet	OBJECTIVES: Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal... Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal replacement... OBJECTIVES:. Acute kidney injury requiring dialysis (AKI-D) commonly occurs in the setting of multiple organ dysfunction syndrome (MODS). Continuous renal...
SourceID	doaj pubmedcentral proquest pubmed crossref wolterskluwer
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	e1084
SubjectTerms	Acute Kidney Injury - physiopathology Acute Kidney Injury - therapy Adolescent Adult Child Child, Preschool Cohort Studies Continuous Renal Replacement Therapy - methods Critical Illness - therapy Female Humans Infant Male Multiple Organ Failure - etiology Multiple Organ Failure - physiopathology Multiple Organ Failure - therapy Observational Study Organ Dysfunction Scores Renal Replacement Therapy - methods Retrospective Studies Young Adult
Title	Patterns of Multiple Organ Dysfunction and Renal Recovery in Critically Ill Children and Young Adults Receiving Continuous Renal Replacement Therapy
URI	https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&DO=10.1097/CCE.0000000000001084 https://www.ncbi.nlm.nih.gov/pubmed/38709083 https://www.proquest.com/docview/3051427112 https://pubmed.ncbi.nlm.nih.gov/PMC11075942 https://doaj.org/article/b80426b857b147e98ead864b24a23d4a
Volume	6
WOSCitedRecordID	wos001275967300004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2639-8028 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002151574 issn: 2639-8028 databaseCode: DOA dateStart: 20190101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2639-8028 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002151574 issn: 2639-8028 databaseCode: M~E dateStart: 20190101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELag6gEJoaLySCmVkbhG3fixto_tdiuQaFWhIu0tcmxHRKy8VdMt2gu_gh_MjJOsdgHRCznkkNhO7Bl7vrHHnwl5rwFygJXQeV0on4O_Uec2cJmPrayYRYNQJ3b9T-ryUs9m5mrjqC-MCevogbuGO640ovxKS1UVQgWjoep6LComLONeJGgEqGfDmcIxGA2ZVGLYK2fU8WQy7bgK-6tIhKYbtihR9v8NZ_4ZLvn0-wKXsttvKZJ9wx6d75FnPZCkJ10FnpNHIe6Tn1eJLjO2dFHTiz5WkKb9lvRs1aIRQ0FQGz39HDA_up-gzSvaRDocezBf0Y_zOZ30-7xT6jQq0BNk62gxU2hwJoIiuVUTl4tluy4vRXnhnCO97hgLXpAv59PryYe8P3chdxKsfe6YDw6AWz0yzBZacSkACBiB5GRKj4OqvPGqsD74YJnxXDvIWIOMQFCsEvwl2YmLGF4Taq3zTuraIxPaiDvDvJEAmQDm2WLkq4zwQQKl60nJ8WyMeTksjoPcyt_llpF8neumI-V4IP0pCnedFim10wNQtLJXtPIhRcvIu0E1SuiCuK5iY4D2LTlyyDMFyDUjrzpVWX-Kw3hoAOZmRG8p0da_bL-JzddE842euTQCCi229K3sdsj-s8YH_6PGb8gTBhAuhXeOD8nO3e0yvCW77v6uaW-PyGM100ep28H94sf0F1RBLkE
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Patterns+of+Multiple+Organ+Dysfunction+and+Renal+Recovery+in+Critically+Ill+Children+and+Young+Adults+Receiving+Continuous+Renal+Replacement+Therapy&rft.jtitle=Critical+care+explorations&rft.au=Thadani%2C+Sameer&rft.au=Fuhrman%2C+Dana&rft.au=Hanson%2C+Claire&rft.au=Park%2C+Hyun+Jung&rft.date=2024-05-06&rft.issn=2639-8028&rft.eissn=2639-8028&rft.volume=6&rft.issue=5&rft.spage=e1084&rft_id=info:doi/10.1097%2FCCE.0000000000001084&rft.externalDBID=n%2Fa&rft.externalDocID=10_1097_CCE_0000000000001084
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2639-8028&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2639-8028&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2639-8028&client=summon