Sex and frequency of pain episodes are associated with acute pain trajectories in adolescents with sickle cell disease
We report that sex and history of high health care utilization for pain are associated with acute pain trajectories in adolescents with sickle cell disease presenting to the emergency department. AbstractIntroduction/Objective:Acute pain episodes are a major cause of health care utilization (HCU) in...
Saved in:
| Published in: | Pain reports Vol. 8; no. 5; p. e1084 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Philadelphia, PA
Wolters Kluwer
01.09.2023
|
| Subjects: | |
| ISSN: | 2471-2531, 2471-2531 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | We report that sex and history of high health care utilization for pain are associated with acute pain trajectories in adolescents with sickle cell disease presenting to the emergency department.
AbstractIntroduction/Objective:Acute pain episodes are a major cause of health care utilization (HCU) in sickle cell disease (SCD), and adolescence is associated with increased pain frequency. We sought to determine whether there were differences in acute pain trajectories by sex and frequency of pain episodes among adolescents with SCD who presented to the emergency department (ED).Methods:Retrospective review of electronic health records from a large, multicampus, pediatric SCD program.Results:Of the 113 adolescents included, the mean age was 16.6 (SD 0.9), 41.6% (n = 47) were female, 77.9% (n = 88) had HbSS or a similarly severe genotype, and 43.4% (n = 49) had ≥3 episodes of HCU for pain, which we defined as having history of high HCU for pain. Those with a history of high HCU for pain had higher mean pain intensity scores at presentation, were more likely to receive either intravenous or intranasal opioids, and were more likely to be hospitalized. In a model considering the 3-way interaction between sex, history of high HCU for pain, and follow-up time from the initial pain intensity score, adjusted for opioid per kilogram body weight, and prescription of hydroxyurea, adolescent female patients with high HCU for pain had the slowest decline in pain intensity during treatment for acute pain in the ED.Conclusion:Sex and history of high HCU for pain are associated with acute pain trajectories in adolescents with SCD presenting to the ED. These novel findings should be confirmed in future prospective studies. |
|---|---|
| AbstractList | Introduction/Objective:. Acute pain episodes are a major cause of health care utilization (HCU) in sickle cell disease (SCD), and adolescence is associated with increased pain frequency. We sought to determine whether there were differences in acute pain trajectories by sex and frequency of pain episodes among adolescents with SCD who presented to the emergency department (ED). Methods:. Retrospective review of electronic health records from a large, multicampus, pediatric SCD program. Results:. Of the 113 adolescents included, the mean age was 16.6 (SD 0.9), 41.6% (n = 47) were female, 77.9% (n = 88) had HbSS or a similarly severe genotype, and 43.4% (n = 49) had ≥3 episodes of HCU for pain, which we defined as having history of high HCU for pain. Those with a history of high HCU for pain had higher mean pain intensity scores at presentation, were more likely to receive either intravenous or intranasal opioids, and were more likely to be hospitalized. In a model considering the 3-way interaction between sex, history of high HCU for pain, and follow-up time from the initial pain intensity score, adjusted for opioid per kilogram body weight, and prescription of hydroxyurea, adolescent female patients with high HCU for pain had the slowest decline in pain intensity during treatment for acute pain in the ED. Conclusion:. Sex and history of high HCU for pain are associated with acute pain trajectories in adolescents with SCD presenting to the ED. These novel findings should be confirmed in future prospective studies. We report that sex and history of high health care utilization for pain are associated with acute pain trajectories in adolescents with sickle cell disease presenting to the emergency department. AbstractIntroduction/Objective:Acute pain episodes are a major cause of health care utilization (HCU) in sickle cell disease (SCD), and adolescence is associated with increased pain frequency. We sought to determine whether there were differences in acute pain trajectories by sex and frequency of pain episodes among adolescents with SCD who presented to the emergency department (ED).Methods:Retrospective review of electronic health records from a large, multicampus, pediatric SCD program.Results:Of the 113 adolescents included, the mean age was 16.6 (SD 0.9), 41.6% (n = 47) were female, 77.9% (n = 88) had HbSS or a similarly severe genotype, and 43.4% (n = 49) had ≥3 episodes of HCU for pain, which we defined as having history of high HCU for pain. Those with a history of high HCU for pain had higher mean pain intensity scores at presentation, were more likely to receive either intravenous or intranasal opioids, and were more likely to be hospitalized. In a model considering the 3-way interaction between sex, history of high HCU for pain, and follow-up time from the initial pain intensity score, adjusted for opioid per kilogram body weight, and prescription of hydroxyurea, adolescent female patients with high HCU for pain had the slowest decline in pain intensity during treatment for acute pain in the ED.Conclusion:Sex and history of high HCU for pain are associated with acute pain trajectories in adolescents with SCD presenting to the ED. These novel findings should be confirmed in future prospective studies. Acute pain episodes are a major cause of health care utilization (HCU) in sickle cell disease (SCD), and adolescence is associated with increased pain frequency. We sought to determine whether there were differences in acute pain trajectories by sex and frequency of pain episodes among adolescents with SCD who presented to the emergency department (ED). Retrospective review of electronic health records from a large, multicampus, pediatric SCD program. Of the 113 adolescents included, the mean age was 16.6 (SD 0.9), 41.6% (n = 47) were female, 77.9% (n = 88) had HbSS or a similarly severe genotype, and 43.4% (n = 49) had ≥3 episodes of HCU for pain, which we defined as having history of high HCU for pain. Those with a history of high HCU for pain had higher mean pain intensity scores at presentation, were more likely to receive either intravenous or intranasal opioids, and were more likely to be hospitalized. In a model considering the 3-way interaction between sex, history of high HCU for pain, and follow-up time from the initial pain intensity score, adjusted for opioid per kilogram body weight, and prescription of hydroxyurea, adolescent female patients with high HCU for pain had the slowest decline in pain intensity during treatment for acute pain in the ED. Sex and history of high HCU for pain are associated with acute pain trajectories in adolescents with SCD presenting to the ED. These novel findings should be confirmed in future prospective studies. We report that sex and history of high health care utilization for pain are associated with acute pain trajectories in adolescents with sickle cell disease presenting to the emergency department. Acute pain episodes are a major cause of health care utilization (HCU) in sickle cell disease (SCD), and adolescence is associated with increased pain frequency. We sought to determine whether there were differences in acute pain trajectories by sex and frequency of pain episodes among adolescents with SCD who presented to the emergency department (ED).Introduction/ObjectiveAcute pain episodes are a major cause of health care utilization (HCU) in sickle cell disease (SCD), and adolescence is associated with increased pain frequency. We sought to determine whether there were differences in acute pain trajectories by sex and frequency of pain episodes among adolescents with SCD who presented to the emergency department (ED).Retrospective review of electronic health records from a large, multicampus, pediatric SCD program.MethodsRetrospective review of electronic health records from a large, multicampus, pediatric SCD program.Of the 113 adolescents included, the mean age was 16.6 (SD 0.9), 41.6% (n = 47) were female, 77.9% (n = 88) had HbSS or a similarly severe genotype, and 43.4% (n = 49) had ≥3 episodes of HCU for pain, which we defined as having history of high HCU for pain. Those with a history of high HCU for pain had higher mean pain intensity scores at presentation, were more likely to receive either intravenous or intranasal opioids, and were more likely to be hospitalized. In a model considering the 3-way interaction between sex, history of high HCU for pain, and follow-up time from the initial pain intensity score, adjusted for opioid per kilogram body weight, and prescription of hydroxyurea, adolescent female patients with high HCU for pain had the slowest decline in pain intensity during treatment for acute pain in the ED.ResultsOf the 113 adolescents included, the mean age was 16.6 (SD 0.9), 41.6% (n = 47) were female, 77.9% (n = 88) had HbSS or a similarly severe genotype, and 43.4% (n = 49) had ≥3 episodes of HCU for pain, which we defined as having history of high HCU for pain. Those with a history of high HCU for pain had higher mean pain intensity scores at presentation, were more likely to receive either intravenous or intranasal opioids, and were more likely to be hospitalized. In a model considering the 3-way interaction between sex, history of high HCU for pain, and follow-up time from the initial pain intensity score, adjusted for opioid per kilogram body weight, and prescription of hydroxyurea, adolescent female patients with high HCU for pain had the slowest decline in pain intensity during treatment for acute pain in the ED.Sex and history of high HCU for pain are associated with acute pain trajectories in adolescents with SCD presenting to the ED. These novel findings should be confirmed in future prospective studies.ConclusionSex and history of high HCU for pain are associated with acute pain trajectories in adolescents with SCD presenting to the ED. These novel findings should be confirmed in future prospective studies. |
| Author | Liu, Zihao Lane, Peter A. Maillis, Alexander Krishnamurti, Lakshmanan Gillespie, Scott E. Bakshi, Nitya Astles, Rachel Lai, Kristina W. Morris, Claudia R. |
| Author_xml | – sequence: 1 givenname: Rachel surname: Astles fullname: Astles, Rachel email: rastles@gmail.com organization: Emory University School of Medicine, Atlanta, GA, USA – sequence: 2 givenname: Zihao surname: Liu fullname: Liu, Zihao email: zihao.liu@emory.edu organization: Rollins School of Public Health, Emory University, Atlanta, GA, USA – sequence: 3 givenname: Scott E. surname: Gillespie fullname: Gillespie, Scott E. email: scott.gillespie@emory.edu organization: Pediatric Biostatistics Core, Department of Pediatrics, Emory University, Atlanta, GA, USA – sequence: 4 givenname: Kristina W. surname: Lai fullname: Lai, Kristina W. email: kwlai@ucdavis.edu organization: Aflac Cancer and Blood Disorders, Children's Healthcare of Atlanta, Atlanta, GA, USA – sequence: 5 givenname: Alexander surname: Maillis fullname: Maillis, Alexander email: Maillis.alex@gmail.com organization: Aflac Cancer and Blood Disorders, Children's Healthcare of Atlanta, Atlanta, GA, USA – sequence: 6 givenname: Claudia R. surname: Morris fullname: Morris, Claudia R. email: claudia.r.morris@emory.edu organization: Division of Pediatric Emergency Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA – sequence: 7 givenname: Peter A. surname: Lane fullname: Lane, Peter A. email: peter.lane@choa.org organization: Division of Pediatric Hematology-Oncology-BMT, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA – sequence: 8 givenname: Lakshmanan surname: Krishnamurti fullname: Krishnamurti, Lakshmanan email: lakshmanan.krishnamurti@yale.edu organization: Division of Pediatric Hematology-Oncology-BMT, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA – sequence: 9 givenname: Nitya orcidid: 0000-0002-0876-9506 surname: Bakshi fullname: Bakshi, Nitya email: nitya.bakshi@emory.edu organization: Division of Pediatric Hematology-Oncology-BMT, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37559677$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUs9vFCEUnpgaW2v_A2M4etkKMzAwXoxpqjZpotHeyRvm0WXLDiuwXfvfyzit2fagXIDH9wMe38vqYAwjVtVrRk8Z7eS7b9-7U7o3GFX8WXVUc8kWtWjYwd76sDpJaTWBOt5R0b6oDhspRNdKeVTd_sBfBMaB2Ig_tziaOxIs2YAbCW5cCgMmAhEJpBSMg4wD2bm8JGC2GWdcjrBCk0N0BVv2MASPyeCY04xNztx4JAa9J4NLCAlfVc8t-IQn9_NxdfXp_Orsy-Ly6-eLs4-XCyNqzheSGdYCdBwtV4ZRiarnUnLRK2aB91wYrIVhnaCDqVWDpd4wCpRbsECb4-pilh0CrPQmujXEOx3A6T-FEK81xOyMR92wepDWSNuA4Ch7xdXQGsZqxakVrS1aH2atzbZf4zC9L4J_JPr4ZHRLfR1uNaOcdpxNt3l7rxBD6XXKeu3S1BUYMWyTLlZK8ZbWvEDf7Jv9dXn4uAJ4PwNMDClFtNq4DNmFydv5YqqnoOgSFP00KIXMn5Af9P9DUzNtF3zGmG78dodRLxF8Xv6b-htEZNI1 |
| CitedBy_id | crossref_primary_10_3390_pharmaceutics16040519 crossref_primary_10_1186_s12913_025_12753_2 |
| Cites_doi | 10.1182/blood-2018-10-880575 10.1182/blood.V106.11.2256.2256 10.1002/jhm.850 10.1016/S0304-3959(00)00269-4 10.1056/NEJM199107043250103 10.1002/pbc.24176 10.1111/bjh.15011 10.1177/1043454214555193 10.1016/j.jpain.2016.12.016 10.1097/MPH.0000000000000787 10.1182/blood.V86.2.776.bloodjournal862776 10.1111/bjh.17658 10.1002/pbc.28067 10.36469/10512 10.1056/NEJM199406093302303 10.1002/ajh.21772 10.1002/ajh.21750 10.1093/bja/aet127 10.1089/jwh.2006.15.146 10.1016/j.pedn.2006.09.001 10.1182/bloodadvances.2018018382 10.1542/peds.2012-2225 10.1001/jama.289.13.1645 10.1038/nrdp.2018.10 10.1002/ajh.21807 10.1097/00002508-200009000-00008 10.1002/jha2.114 |
| ContentType | Journal Article |
| Copyright | Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. 2023 |
| Copyright_xml | – notice: Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. – notice: Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. 2023 |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.1097/PR9.0000000000001084 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2471-2531 |
| ExternalDocumentID | oai_doaj_org_article_312d7fc7f3a54e7b848d6c112840f56f PMC10409410 37559677 10_1097_PR9_0000000000001084 PAINREPORTS-D-22-0109 |
| Genre | research-article Journal Article |
| GrantInformation_xml | – fundername: NCCIH NIH HHS grantid: K24 AT009893 – fundername: NHLBI NIH HHS grantid: K23 HL140142 |
| GroupedDBID | 026 0R~ AAAAV AAGIX AAHPQ AAIQE AAMOA AAQKA AASCR AASXQ AAUEB ABASU ABDIG ABVCZ ABZZY ACDOF ACEWG ACGFS ACILI ACLDA ACNWC ACOAL ACXJB ACZKN ADBBV ADGGA ADHPY ADPDF AFBFQ AFDTB AFMBP AFSOK AHOMT AHQNM AHXIK AIJEX AINUH AJCLO AJIOK AJNWD AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOIJS AOQMC BCNDV BQLVK BYPQX DIWNM EBS EEVPB ERAAH FCALG GNXGY GQDEL GROUPED_DOAJ HLJTE HYE IKREB IKYAY M~E O9- OBH OK1 OPUJH OVD OVDNE OVIDH OVLEI OVOZU OXXIT RLZ RPM TEORI TSPGW AAYXX ACBKD ADKSD ADSXY AHVBC CITATION EJD NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c5244-71c16aa94ef48c107e8b47745b81fa4b45ce25c1950dc283eb81310a04fafa03 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 2 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001043389700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2471-2531 |
| IngestDate | Tue Oct 14 19:08:34 EDT 2025 Tue Nov 04 02:06:16 EST 2025 Sun Sep 28 02:01:54 EDT 2025 Mon Jul 21 06:00:03 EDT 2025 Sat Nov 29 04:41:08 EST 2025 Tue Nov 18 22:29:05 EST 2025 Wed Apr 16 02:18:00 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Pain episode Vaso-occlusive crisis Trajectories Pain Sickle cell Sex |
| Language | English |
| License | http://creativecommons.org/licenses/by-nc-nd/4.0 Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5244-71c16aa94ef48c107e8b47745b81fa4b45ce25c1950dc283eb81310a04fafa03 |
| Notes | Corresponding author. Address: Division of Pediatric Hematology-Oncology-BMT, Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Dr, Atlanta, GA 30322. E-mail address: nitya.bakshi@emory.edu (N. Bakshi).Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-0876-9506 |
| OpenAccessLink | https://doaj.org/article/312d7fc7f3a54e7b848d6c112840f56f |
| PMID | 37559677 |
| PQID | 2848846024 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_312d7fc7f3a54e7b848d6c112840f56f pubmedcentral_primary_oai_pubmedcentral_nih_gov_10409410 proquest_miscellaneous_2848846024 pubmed_primary_37559677 crossref_citationtrail_10_1097_PR9_0000000000001084 crossref_primary_10_1097_PR9_0000000000001084 wolterskluwer_health_10_1097_PR9_0000000000001084 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-09-01 |
| PublicationDateYYYYMMDD | 2023-09-01 |
| PublicationDate_xml | – month: 09 year: 2023 text: 2023-09-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Philadelphia, PA |
| PublicationPlace_xml | – name: Philadelphia, PA – name: United States |
| PublicationTitle | Pain reports |
| PublicationTitleAbbrev | PR9 |
| PublicationTitleAlternate | Pain Rep |
| PublicationYear | 2023 |
| Publisher | Wolters Kluwer |
| Publisher_xml | – name: Wolters Kluwer |
| References | McClish, Levenson, Penberthy, Roseff, Bovbjerg, Roberts, Aisiku, Smith (R17) 2006; 15 Dampier, Palermo, Darbari, Hassell, Smith, Zempsky (R6) 2017; 18 Fosdal (R9) 2015; 32 Approximate dose conversions for commonly used opioids. UpToDate Inc. Available at: https://www.uptodate.com/contents/image?imageKey=PALC%2F111216. Accessed 15 April, 2021. Lanzkron, Carroll, Haywood (R15) 2010; 85 Stallworth, Jerrell, Tripathi (R26) 2010; 85 Jacob, Mueller, Cochrane, Carroll, Bennett (R12) 2020; 67 Platt, Brambilla, Rosse, Milner, Castro, Steinberg, Klug (R24) 1994; 330 Chawla, Sprinz, Welch, Heeney, Usmani, Pashankar, Kavanagh (R5) 2013; 131 Ballas, Bauserman, McCarthy, Castro, Smith, Waclawiw (R2) 2010; 85 Bartley, Fillingim (R3) 2013; 111 Gill, Sleeper, Weiner, Brown, Bellevue, Grover, Pegelow, Vichinsky (R10) 1995; 86 Lanzkron, Little, Field, Shows, Wang, Seufert, Brooks, Varadhan, Haywood, Saheed, Huang, Griffin, Frymark, Piehet, Robertson, Proudford, Kincaid, Green, Burgess, Wallace, Segal (R16) 2018; 2 Opioid oral morphine milligram equivalent (MME) conversion factors. Available at: https://medicaid.utah.gov/Documents/files/Opioid-Morphine-EQ-Conversion-Factors.pdf. Accessed 15 April, 2021. Pecker, Sharma, Nero, Paidas, Ware, James, Smith-Whitley (R20) 2021; 194 Kato, Piel, Reid, Gaston, Ohene-Frempong, Krishnamurti, Smith, Panepinto, Weatherall, Costa, Vichinsky (R14) 2018; 4 Perquin, Hazebroek-Kampschreur, Hunfeld, Bohnen, van Suijlekom-Smit, Passchier, van der Wouden (R21) 2000; 87 Wonkam, Mnika, Ngo Bitoungui, Chetcha Chemegni, Chimusa, Dandara, Kengne (R28) 2018; 180 DeBaun, Ghafuri, Rodeghier, Maitra, Chaturvedi, Kassim, Ataga (R7) 2019; 133 Rodday, Esham, Savidge, Parsons (R25) 2020; 1 Carroll, Haywood, Lanzkron (R4) 2011; 6 Haywood, Lanzkron (R11) 2005; 106 Perquin, Hazebroek-Kampschreur, Hunfeld, van Suijlekom-Smit, Passchier, van der Wouden (R22) 2000; 16 Steinberg, Barton, Castro, Pegelow, Ballas, Kutlar, Orringer, Bellevue, Olivieri, Eckman, Varma, Ramirez, Adler, Smith, Carlos, Ataga, DeCastro, Bigelow, Saunthararajah, Telfer, Vichinsky, Claster, Shurin, Bridges, Waclawiw, Bonds, Terrin (R27) 2003; 289 Kanter, Bhor, Li, Li, Paulose (R13) 2019; 6 Zivot, Apollonsky, Gracely, Raybagkar (R29) 2017; 39 Platt, Thorington, Brambilla, Milner, Rosse, Vichinsky, Kinney (R23) 1991; 325 Fosdal, Wojner-Alexandrov (R8) 2007; 22 Panepinto, Bonner (R19) 2012; 59 Perquin (R21-20240807) 2000; 87 Kanter (R13-20240807) 2019; 6 Fosdal (R9-20240807) 2015; 32 Lanzkron (R15-20240807) 2010; 85 Haywood (R11-20240807) 2005; 106 Lanzkron (R16-20240807) 2018; 2 Jacob (R12-20240807) 2020; 67 Platt (R23-20240807) 1991; 325 Dampier (R6-20240807) 2017; 18 Ballas (R2-20240807) 2010; 85 Carroll (R4-20240807) 2011; 6 DeBaun (R7-20240807) 2019; 133 McClish (R17-20240807) 2006; 15 Wonkam (R28-20240807) 2018; 180 Pecker (R20-20240807) 2021; 194 Gill (R10-20240807) 1995; 86 Zivot (R29-20240807) 2017; 39 Fosdal (R8-20240807) 2007; 22 Perquin (R22-20240807) 2000; 16 Steinberg (R27-20240807) 2003; 289 Panepinto (R19-20240807) 2012; 59 Platt (R24-20240807) 1994; 330 Bartley (R3-20240807) 2013; 111 Rodday (R25-20240807) 2020; 1 Kato (R14-20240807) 2018; 4 Stallworth (R26-20240807) 2010; 85 Chawla (R5-20240807) 2013; 131 |
| References_xml | – volume: 22 start-page: 342 year: 2007 end-page: 6 ident: R8 article-title: Events of hospitalization among children with sickle cell disease publication-title: J Pediatr Nurs – volume: 67 start-page: e28067 year: 2020 ident: R12 article-title: Variation in hospital admission of sickle cell patients from the emergency department using the Pediatric Health Information System publication-title: Pediatr Blood Cancer – volume: 85 start-page: 613 year: 2010 end-page: 6 ident: R2 article-title: Utilization of analgesics in the multicenter study of hydroxyurea in sickle cell anemia: effect of sex, age, and geographical location publication-title: Am J Hematol – volume: 59 start-page: 377 year: 2012 end-page: 85 ident: R19 article-title: Health-related quality of life in sickle cell disease: past, present, and future publication-title: Pediatr Blood Cancer – reference: Opioid oral morphine milligram equivalent (MME) conversion factors. Available at: https://medicaid.utah.gov/Documents/files/Opioid-Morphine-EQ-Conversion-Factors.pdf. Accessed 15 April, 2021. – volume: 194 start-page: 970 year: 2021 end-page: 9 ident: R20 article-title: Knowledge gaps in reproductive and sexual health in girls and women with sickle cell disease publication-title: Br J Haematol – volume: 87 start-page: 51 year: 2000 end-page: 8 ident: R21 article-title: Pain in children and adolescents: a common experience publication-title: PAIN – volume: 16 start-page: 229 year: 2000 end-page: 35 ident: R22 article-title: Chronic pain among children and adolescents: physician consultation and medication use publication-title: Clin J Pain – volume: 86 start-page: 776 year: 1995 end-page: 83 ident: R10 article-title: Clinical events in the first decade in a cohort of infants with sickle cell disease. Cooperative Study of Sickle Cell Disease publication-title: Blood – volume: 330 start-page: 1639 year: 1994 end-page: 44 ident: R24 article-title: Mortality in sickle cell disease. Life expectancy and risk factors for early death publication-title: N Engl J Med – volume: 2 start-page: 2412 year: 2018 end-page: 7 ident: R16 article-title: Increased acute care utilization in a prospective cohort of adults with sickle cell disease publication-title: Blood Adv – volume: 6 start-page: 248 year: 2011 end-page: 55 ident: R4 article-title: Prediction of onset and course of high hospital utilization in sickle cell disease publication-title: J Hosp Med – volume: 289 start-page: 1645 year: 2003 end-page: 51 ident: R27 article-title: Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment publication-title: JAMA – volume: 32 start-page: 5 year: 2015 end-page: 20 ident: R9 article-title: Perception of pain among pediatric patients with sickle cell pain crisis publication-title: J Pediatr Oncol Nurs – volume: 6 start-page: 174 year: 2019 end-page: 84 ident: R13 article-title: High healthcare utilization in adolescents with sickle cell disease prior to transition to adult care: a retrospective study publication-title: J Health Econ Outcomes Res – volume: 4 start-page: 18010 year: 2018 ident: R14 article-title: Sickle cell disease publication-title: Nat Rev Dis Primers – volume: 325 start-page: 11 year: 1991 end-page: 6 ident: R23 article-title: Pain in sickle cell disease. Rates and risk factors publication-title: N Engl J Med – volume: 85 start-page: 795 year: 2010 end-page: 7 ident: R26 article-title: Cost-effectiveness of hydroxyurea in reducing the frequency of pain episodes and hospitalization in pediatric sickle cell disease publication-title: Am J Hematol – volume: 106 start-page: 2256 year: 2005 ident: R11 article-title: Gender differences in hospitalized patients with sickle cell disease (SCD): 1990-2002 publication-title: Blood – volume: 85 start-page: 797 year: 2010 end-page: 9 ident: R15 article-title: The burden of emergency department use for sickle-cell disease: an analysis of the national emergency department sample database publication-title: Am J Hematol – volume: 111 start-page: 52 year: 2013 end-page: 8 ident: R3 article-title: Sex differences in pain: a brief review of clinical and experimental findings publication-title: Br J Anaesth – volume: 133 start-page: 615 year: 2019 end-page: 7 ident: R7 article-title: Decreased median survival of adults with sickle cell disease after adjusting for left truncation bias: a pooled analysis publication-title: Blood – volume: 1 start-page: 426 year: 2020 end-page: 37 ident: R25 article-title: Clusters of pain trajectories among patients with sickle cell disease hospitalized for vaso-occlusive crisis: a data-driven approach publication-title: EJHaem – volume: 39 start-page: 314 year: 2017 end-page: 7 ident: R29 article-title: Body mass index and the association with vaso-occlusive crises in pediatric sickle cell disease publication-title: J Pediatr Hematol Oncol – volume: 18 start-page: 490 year: 2017 end-page: 8 ident: R6 article-title: AAPT diagnostic criteria for chronic sickle cell disease pain publication-title: J Pain – volume: 15 start-page: 146 year: 2006 end-page: 54 ident: R17 article-title: Gender differences in pain and healthcare utilization for adult sickle cell patients: the PiSCES project publication-title: J Womens Health (Larchmt) – reference: Approximate dose conversions for commonly used opioids. UpToDate Inc. Available at: https://www.uptodate.com/contents/image?imageKey=PALC%2F111216. Accessed 15 April, 2021. – volume: 180 start-page: 134 year: 2018 end-page: 46 ident: R28 article-title: Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon publication-title: Br J Haematol – volume: 131 start-page: e1168 year: 2013 end-page: 73 ident: R5 article-title: Weight status of children with sickle cell disease publication-title: Pediatrics – volume: 133 start-page: 615 year: 2019 ident: R7-20240807 article-title: Decreased median survival of adults with sickle cell disease after adjusting for left truncation bias: a pooled analysis publication-title: Blood doi: 10.1182/blood-2018-10-880575 – volume: 106 start-page: 2256 year: 2005 ident: R11-20240807 article-title: Gender differences in hospitalized patients with sickle cell disease (SCD): 1990–2002 publication-title: Blood doi: 10.1182/blood.V106.11.2256.2256 – volume: 6 start-page: 248 year: 2011 ident: R4-20240807 article-title: Prediction of onset and course of high hospital utilization in sickle cell disease publication-title: J Hosp Med doi: 10.1002/jhm.850 – volume: 87 start-page: 51 year: 2000 ident: R21-20240807 article-title: Pain in children and adolescents: a common experience publication-title: PAIN doi: 10.1016/S0304-3959(00)00269-4 – volume: 325 start-page: 11 year: 1991 ident: R23-20240807 article-title: Pain in sickle cell disease. Rates and risk factors publication-title: N Engl J Med doi: 10.1056/NEJM199107043250103 – volume: 59 start-page: 377 year: 2012 ident: R19-20240807 article-title: Health-related quality of life in sickle cell disease: past, present, and future publication-title: Pediatr Blood Cancer doi: 10.1002/pbc.24176 – volume: 180 start-page: 134 year: 2018 ident: R28-20240807 article-title: Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon publication-title: Br J Haematol doi: 10.1111/bjh.15011 – volume: 32 start-page: 5 year: 2015 ident: R9-20240807 article-title: Perception of pain among pediatric patients with sickle cell pain crisis publication-title: J Pediatr Oncol Nurs doi: 10.1177/1043454214555193 – volume: 18 start-page: 490 year: 2017 ident: R6-20240807 article-title: AAPT diagnostic criteria for chronic sickle cell disease pain publication-title: J Pain doi: 10.1016/j.jpain.2016.12.016 – volume: 39 start-page: 314 year: 2017 ident: R29-20240807 article-title: Body mass index and the association with vaso-occlusive crises in pediatric sickle cell disease publication-title: J Pediatr Hematol Oncol doi: 10.1097/MPH.0000000000000787 – volume: 86 start-page: 776 year: 1995 ident: R10-20240807 article-title: Clinical events in the first decade in a cohort of infants with sickle cell disease. Cooperative Study of Sickle Cell Disease publication-title: Blood doi: 10.1182/blood.V86.2.776.bloodjournal862776 – volume: 194 start-page: 970 year: 2021 ident: R20-20240807 article-title: Knowledge gaps in reproductive and sexual health in girls and women with sickle cell disease publication-title: Br J Haematol doi: 10.1111/bjh.17658 – volume: 67 start-page: e28067 year: 2020 ident: R12-20240807 article-title: Variation in hospital admission of sickle cell patients from the emergency department using the Pediatric Health Information System publication-title: Pediatr Blood Cancer doi: 10.1002/pbc.28067 – volume: 6 start-page: 174 year: 2019 ident: R13-20240807 article-title: High healthcare utilization in adolescents with sickle cell disease prior to transition to adult care: a retrospective study publication-title: J Health Econ Outcomes Res doi: 10.36469/10512 – volume: 330 start-page: 1639 year: 1994 ident: R24-20240807 article-title: Mortality in sickle cell disease. Life expectancy and risk factors for early death publication-title: N Engl J Med doi: 10.1056/NEJM199406093302303 – volume: 85 start-page: 795 year: 2010 ident: R26-20240807 article-title: Cost-effectiveness of hydroxyurea in reducing the frequency of pain episodes and hospitalization in pediatric sickle cell disease publication-title: Am J Hematol doi: 10.1002/ajh.21772 – volume: 85 start-page: 613 year: 2010 ident: R2-20240807 article-title: Utilization of analgesics in the multicenter study of hydroxyurea in sickle cell anemia: effect of sex, age, and geographical location publication-title: Am J Hematol doi: 10.1002/ajh.21750 – volume: 111 start-page: 52 year: 2013 ident: R3-20240807 article-title: Sex differences in pain: a brief review of clinical and experimental findings publication-title: Br J Anaesth doi: 10.1093/bja/aet127 – volume: 15 start-page: 146 year: 2006 ident: R17-20240807 article-title: Gender differences in pain and healthcare utilization for adult sickle cell patients: the PiSCES project publication-title: J Womens Health (Larchmt) doi: 10.1089/jwh.2006.15.146 – volume: 22 start-page: 342 year: 2007 ident: R8-20240807 article-title: Events of hospitalization among children with sickle cell disease publication-title: J Pediatr Nurs doi: 10.1016/j.pedn.2006.09.001 – volume: 2 start-page: 2412 year: 2018 ident: R16-20240807 article-title: Increased acute care utilization in a prospective cohort of adults with sickle cell disease publication-title: Blood Adv doi: 10.1182/bloodadvances.2018018382 – volume: 131 start-page: e1168 year: 2013 ident: R5-20240807 article-title: Weight status of children with sickle cell disease publication-title: Pediatrics doi: 10.1542/peds.2012-2225 – volume: 289 start-page: 1645 year: 2003 ident: R27-20240807 article-title: Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment publication-title: JAMA doi: 10.1001/jama.289.13.1645 – volume: 4 start-page: 18010 year: 2018 ident: R14-20240807 article-title: Sickle cell disease publication-title: Nat Rev Dis Primers doi: 10.1038/nrdp.2018.10 – volume: 85 start-page: 797 year: 2010 ident: R15-20240807 article-title: The burden of emergency department use for sickle-cell disease: an analysis of the national emergency department sample database publication-title: Am J Hematol doi: 10.1002/ajh.21807 – volume: 16 start-page: 229 year: 2000 ident: R22-20240807 article-title: Chronic pain among children and adolescents: physician consultation and medication use publication-title: Clin J Pain doi: 10.1097/00002508-200009000-00008 – volume: 1 start-page: 426 year: 2020 ident: R25-20240807 article-title: Clusters of pain trajectories among patients with sickle cell disease hospitalized for vaso-occlusive crisis: a data-driven approach publication-title: EJHaem doi: 10.1002/jha2.114 |
| SSID | ssj0001949056 |
| Score | 2.2514627 |
| Snippet | We report that sex and history of high health care utilization for pain are associated with acute pain trajectories in adolescents with sickle cell disease... Acute pain episodes are a major cause of health care utilization (HCU) in sickle cell disease (SCD), and adolescence is associated with increased pain... Introduction/Objective:. Acute pain episodes are a major cause of health care utilization (HCU) in sickle cell disease (SCD), and adolescence is associated... |
| SourceID | doaj pubmedcentral proquest pubmed crossref wolterskluwer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | e1084 |
| SubjectTerms | Pediatric |
| Title | Sex and frequency of pain episodes are associated with acute pain trajectories in adolescents with sickle cell disease |
| URI | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&DO=10.1097/PR9.0000000000001084 https://www.ncbi.nlm.nih.gov/pubmed/37559677 https://www.proquest.com/docview/2848846024 https://pubmed.ncbi.nlm.nih.gov/PMC10409410 https://doaj.org/article/312d7fc7f3a54e7b848d6c112840f56f |
| Volume | 8 |
| WOSCitedRecordID | wos001043389700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2471-2531 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001949056 issn: 2471-2531 databaseCode: DOA dateStart: 20160101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2471-2531 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001949056 issn: 2471-2531 databaseCode: M~E dateStart: 20160101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BhRASQjxLeFRG4ho1TpzYOQJqxaVVBT3sLfJjLJZWyWqzW-ilv51xnF1lAdELOawU72w29kzsb8aTbwDeG5_Z2hc65aYoUpG7LFWVK9LK1KXJhBRe26HYhDw9VbNZfTYp9RVywiI9cBy4w4LnTnor6XqlQGmUUK6yPEyrmS8rH2ZfQj0TZ2qIrtSipqV9865cLQ_PvtSRq3A8-EBoOlmLBsr-v-HMP9MlH_7owlZ2fzFksk_Wo-PH8GgEkuxD7MATuIPtU7h_Mm6VP4Orr_iT6dYxv4zZ0tes82yh5y3DxbzvHPZML5HpUT_oWIjJMm3XK4xydBvfh6A-edOMzifsT1GWNHxxiSwE_9m40_Mczo-Pzj99TsciC6ktaWlPJbe80roW6IWy5AyiMoIwYWkU91oYUVrMSxuqxTpLWASpnSChzkiLXmfFC9hruxZfAnNFztEZx00IK9pMoVeOZ9RQoiWgk0CxGe3GjgTkoQ7GZbPZCCcdNb_rKIF0-6tFJOC4Rf5jUORWNtBnDw1kVM1oVM1tRpXAu40ZNPS4hWHULXbrviEJRZCNkE0C-9Estn9VSHLPKikTUDsGs3Mvu9-0828DpTc5xeRn8ywBvmNbTXwb9p89fvU_evwaHuQE32L23BvYWy3X-Bbu2avVvF8ewF05UwfDI0afJzdHvwC37igJ |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sex+and+frequency+of+pain+episodes+are+associated+with+acute+pain+trajectories+in+adolescents+with+sickle+cell+disease&rft.jtitle=Pain+reports&rft.au=Astles%2C+Rachel&rft.au=Liu%2C+Zihao&rft.au=Gillespie%2C+Scott+E&rft.au=Lai%2C+Kristina+W&rft.date=2023-09-01&rft.issn=2471-2531&rft.eissn=2471-2531&rft.volume=8&rft.issue=5&rft.spage=e1084&rft_id=info:doi/10.1097%2FPR9.0000000000001084&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2471-2531&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2471-2531&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2471-2531&client=summon |