Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing

Summary Background Enumeration of extracellular vesicles has clinical potential as a biomarker for disease. In biological samples, the smallest and largest vesicles typically differ 25‐fold in size, 300 000‐fold in concentration, 20 000‐fold in volume, and 10 000 000‐fold in scattered light. Because...

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Bibliographic Details
Published in:	Journal of thrombosis and haemostasis Vol. 12; no. 7; pp. 1182 - 1192
Main Authors:	Pol, E., Coumans, F. A. W., Grootemaat, A. E., Gardiner, C., Sargent, I. L., Harrison, P., Sturk, A., Leeuwen, T. G., Nieuwland, R.
Format:	Journal Article
Language:	English
Published:	England Elsevier Limited 01.07.2014
Subjects:	Biomarkers - metabolism Cell-Derived Microparticles - metabolism cell‐derived microparticles exosomes Exosomes - metabolism Flow Cytometry Humans Microscopy, Electron, Transmission Nanoparticles - chemistry optical devices Optics and Photonics Particle Size reference standards Refractometry Reproducibility of Results secretory vesicles cell-derived microparticles optical devices reference standards exosomes secretory vesicles
ISSN:	1538-7933, 1538-7836, 1538-7836
Online Access:	Get full text
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