S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis

Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly exposed to microbes and their products. However, the role of microbes in itch generation is unknown. Here, we show that Staphylococcus aureus, a bacterial pathogen associated with itchy skin diseases, dir...

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Bibliographic Details
Published in:	Cell Vol. 186; no. 24; p. 5375
Main Authors:	Deng, Liwen, Costa, Flavia, Blake, Kimbria J, Choi, Samantha, Chandrabalan, Arundhasa, Yousuf, Muhammad Saad, Shiers, Stephanie, Dubreuil, Daniel, Vega-Mendoza, Daniela, Rolland, Corinne, Deraison, Celine, Voisin, Tiphaine, Bagood, Michelle D, Wesemann, Lucia, Frey, Abigail M, Palumbo, Joseph S, Wainger, Brian J, Gallo, Richard L, Leyva-Castillo, Juan-Manuel, Vergnolle, Nathalie, Price, Theodore J, Ramachandran, Rithwik, Horswill, Alexander R, Chiu, Isaac M
Format:	Journal Article
Language:	English
Published:	United States 22.11.2023
Subjects:	Animals Humans Mice Peptide Hydrolases - metabolism Pruritus - microbiology Receptor, PAR-1 - metabolism Staphylococcal Infections - microbiology Staphylococcal Infections - pathology Staphylococcus aureus - enzymology Staphylococcus aureus - pathogenicity Staphylococcus aureus - physiology itch pruriceptor PAR1 proteinase-activated receptor V8 protease microbe Staphylococcus aureus
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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