Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment

In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, and predict outcomes. Here, we investigate the potential of retinal optical coherence tomography (OCT) to achieve these ends in a series of pr...

Full description

Saved in:
Bibliographic Details
Published in:Nature communications Vol. 14; no. 1; pp. 7720 - 13
Main Authors: Farrah, Tariq E., Pugh, Dan, Chapman, Fiona A., Godden, Emily, Balmforth, Craig, Oniscu, Gabriel C., Webb, David J., Dhillon, Baljean, Dear, James W., Bailey, Matthew A., Gallacher, Peter J., Dhaun, Neeraj
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 05.12.2023
Nature Publishing Group
Nature Portfolio
Subjects:
631/443/592/75/593/2724
692/4022/1585/104/1586
692/53/2422
Biomarkers
Choroid - diagnostic imaging
Dialysis
Epidermal growth factor receptors
Humanities and Social Sciences
Humans
Injuries
Kidney diseases
Kidney transplantation
Kidney transplants
multidisciplinary
Optical Coherence Tomography
Organ donors
Prospective Studies
Renal failure
Renal Insufficiency, Chronic
Retina
Retina - diagnostic imaging
Retinal Degeneration
Science
Science (multidisciplinary)
Thickness
Thinning
Tomography, Optical Coherence - methods
ISSN:2041-1723, 2041-1723
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, and predict outcomes. Here, we investigate the potential of retinal optical coherence tomography (OCT) to achieve these ends in a series of prospective studies of patients with pre-dialysis CKD (including those with a kidney transplant), patients with kidney failure undergoing kidney transplantation, living kidney donors, and healthy volunteers. Compared to health, we observe similar retinal thinning and reduced macular volume in patients with CKD and in those with a kidney transplant. However, the choroidal thinning observed in CKD is not seen in patients with a kidney transplant whose choroids resemble those of healthy volunteers. In CKD, the degree of choroidal thinning relates to falling eGFR and extent of kidney scarring. Following kidney transplantation, choroidal thickness increases rapidly (~10%) and is maintained over 1-year, whereas gradual choroidal thinning is seen during the 12 months following kidney donation. In patients with CKD, retinal and choroidal thickness independently associate with eGFR decline over 2 years. These observations highlight the potential for retinal OCT to act as a non-invasive monitoring and prognostic biomarker of kidney injury. In patients with CKD, there is an unmet need for biomarkers that reliably track kidney injury. Here, in a series of prospective studies, the authors show that retinal OCT metrics reflect kidney injury, are modified by treatments for kidney disease and can predict future decline of kidney function.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-43125-1