Various modes of cell death induced by DNA damage

The consequences of DNA damage depend on the cell type and the severity of the damage. Mild DNA damage can be repaired with or without cell-cycle arrest. More severe and irreparable DNA injury leads to the appearance of cells that carry mutations or causes a shift towards induction of the senescence...

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Vydáno v:	Oncogene Ročník 32; číslo 33; s. 3789 - 3797
Hlavní autoři:	Surova, O, Zhivotovsky, B
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 15.08.2013 Nature Publishing Group
Témata:	631/337/1427 631/67/1059 631/80/82 Animals Apoptosis Autophagy Cell Biology Cell cycle Cell death Cell Death - physiology Decision making Deoxyribonucleic acid DNA DNA damage DNA Damage - physiology DNA repair Gene expression Genetic aspects Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Necrosis Oncology review Senescence Signal transduction Sweden senescence cell death DNA damage response p53
ISSN:	0950-9232, 1476-5594, 1476-5594
On-line přístup:	Získat plný text
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Shrnutí:	The consequences of DNA damage depend on the cell type and the severity of the damage. Mild DNA damage can be repaired with or without cell-cycle arrest. More severe and irreparable DNA injury leads to the appearance of cells that carry mutations or causes a shift towards induction of the senescence or cell death programs. Although for many years it was argued that DNA damage kills cells via apoptosis or necrosis, technical and methodological progress during the last few years has helped to reveal that this injury might also activate death by autophagy or mitotic catastrophe, which may then be followed by apoptosis or necrosis. The molecular basis underlying the decision-making process is currently the subject of intense investigation. Here, we review current knowledge about the response to DNA damage and subsequent signaling, with particular attention to cell death induction and the molecular switches between different cell death modalities following damage.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Literature Review-2 ObjectType-Feature-3 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0950-9232 1476-5594 1476-5594
DOI:	10.1038/onc.2012.556