An Effective DNA Methylation Biomarker Screening Mechanism for Amyotrophic Lateral Sclerosis (ALS) Based on Comorbidities and Gene Function Analysis

This study used epigenomic methylation differential expression analysis to identify primary biomarkers in patients with amyotrophic lateral sclerosis (ALS). We combined electronic medical record datasets from MIMIC-IV (United States) and NHIRD (Taiwan) to explore ALS comorbidities in depth and disco...

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Veröffentlicht in:	Bioengineering (Basel) Jg. 11; H. 10; S. 1020
Hauptverfasser:	Yang, Cing-Han, Huang, Jhen-Li, Tsai, Li-Kai, Taniar, David, Pai, Tun-Wen
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 01.10.2024 MDPI
Schlagworte:	Amyotrophic lateral sclerosis amyotrophic lateral sclerosis (ALS) Analysis Annotations bioinformatics Biological markers biomarker screening platform Biomarkers Care and treatment Comorbidity Deoxyribonucleic acid Development and progression Diagnosis DNA DNA methylation Electronic health records Electronic medical records ErbB-2 protein Function analysis Gene expression Genetic aspects Health aspects Methylation Neurodegeneration Patients Statistical analysis Taiwan DNA methylation comorbidity biomarker screening platform amyotrophic lateral sclerosis (ALS) bioinformatics
ISSN:	2306-5354, 2306-5354
Online-Zugang:	Volltext
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