The Key Roles of Interferon Lambda in Human Molecular Defense against Respiratory Viral Infections

Interferons (IFN) are crucial for the innate immune response. Slightly more than two decades ago, a new type of IFN was discovered: the lambda IFN (type III IFN). Like other IFN, the type III IFN display antiviral activity against a wide variety of infections, they induce expression of antiviral, in...

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Bibliographic Details
Published in:	Pathogens (Basel) Vol. 9; no. 12; p. 989
Main Authors:	Lozhkov, Alexey A., Klotchenko, Sergey A., Ramsay, Edward S., Moshkoff, Herman D., Moshkoff, Dmitry A., Vasin, Andrey V., Salvato, Maria S.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 26.11.2020 MDPI
Subjects:	Adaptive immunity Antiviral activity Antiviral agents antiviral properties Bacterial diseases bacterial infections Epithelial cells epithelium Gene expression genes humans Immune response Immune system infection Influenza Innate immunity Interferon interferon stimulated genes interferons interferons-α/β interferons-λ Kinases Mucosa Myxovirus resistance proteins nose Orthomyxoviridae pandemic Pandemics Pathogenesis pathogens Public health receptors respiratory viruses Review risk Sensors shape therapeutics Viral infections Viruses influenza innate immunity interferons-α/β respiratory viruses interferon stimulated genes interferons-λ
ISSN:	2076-0817, 2076-0817
Online Access:	Get full text
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