Practice and knowledge about diagnosis and treatment of alpha-1 antitrypsin deficiency in Spain and Portugal
Background Determining physicians’ awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and expected number of patients diagnosed with this disease. This study was designed to assess the opinions on knowledge, practice pattern and attit...
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| Vydáno v: | BMC pulmonary medicine Ročník 16; číslo 1 |
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| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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BioMed Central
27.04.2016
BioMed Central Ltd Springer Nature B.V |
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| ISSN: | 1471-2466, 1471-2466 |
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| Abstract | Background
Determining physicians’ awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and expected number of patients diagnosed with this disease.
This study was designed to assess the opinions on knowledge, practice pattern and attitude regarding AATD among physicians in Spain and Portugal.
Methods
An online anonymous survey was performed on pulmonologists (
n
= 100), internal medicine specialists (IMS) (
n
= 100) and primary care physicians (PCP) (
n
= 176). Of the total number of physicians, 221 were from Spain, and 155 were from Portugal. Physicians answered 21 questions related to their personal and professional profile, knowledge regarding AATD and chronic obstructive pulmonary disease (COPD), performance and attitude about AATD, and use of augmentation therapy. Responses were ranked on a 4-point scale indicating the level of agreement. In addition, some of the responses were rated as either “low” or “high” indicating the level of knowledge the respondent felt he/she possessed.
Results
Only 14 % of physicians reported to “know very well” about AATD (3.3 [SD 0.6] for pulmonologists vs. 2.64 [SD 0.60] for IMS and 2.48 [SD 0.71] for PCP;
p
< 0.001). Only 45.2 % of physicians correctly answered “<50 mg/dL” as the threshold value of serum AAT to be considered severe AATD (55.0 % of pulmonologists vs. 47.0 % of IMS and 38.6 % of PCP;
p
= 0.001). Choice of the correct answer did not agree with those physicians self-declaring a high level of AATD knowledge (51.2 %). A total of 43.9 % of physicians correctly identified all diseases or conditions in a list associated or not with AATD. A similar trend was detected when identifying which conditions would be responsive to augmentation therapy (<50 %). Only 15.8 % of specialists performed AATD testing in all patients with COPD (27.0 % pulmonologists, 12.6 % PCP;
p
= 0.001).
Conclusion
The results suggest that a knowledge gap may be contributing to the underdiagnosis of AATD. Physicians in Spain and Portugal showed a marked lack of awareness of their shortcomings in knowledge about AATD, and in general did not follow guidelines and recommendations for AATD testing. |
|---|---|
| AbstractList | Background Determining physicians' awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and expected number of patients diagnosed with this disease. This study was designed to assess the opinions on knowledge, practice pattern and attitude regarding AATD among physicians in Spain and Portugal. Methods An online anonymous survey was performed on pulmonologists (n = 100), internal medicine specialists (IMS) (n = 100) and primary care physicians (PCP) (n = 176). Of the total number of physicians, 221 were from Spain, and 155 were from Portugal. Physicians answered 21 questions related to their personal and professional profile, knowledge regarding AATD and chronic obstructive pulmonary disease (COPD), performance and attitude about AATD, and use of augmentation therapy. Responses were ranked on a 4-point scale indicating the level of agreement. In addition, some of the responses were rated as either "low" or "high" indicating the level of knowledge the respondent felt he/she possessed. Results Only 14 % of physicians reported to "know very well" about AATD (3.3 [SD 0.6] for pulmonologists vs. 2.64 [SD 0.60] for IMS and 2.48 [SD 0.71] for PCP; p < 0.001). Only 45.2 % of physicians correctly answered "<50 mg/dL" as the threshold value of serum AAT to be considered severe AATD (55.0 % of pulmonologists vs. 47.0 % of IMS and 38.6 % of PCP; p = 0.001). Choice of the correct answer did not agree with those physicians self-declaring a high level of AATD knowledge (51.2 %). A total of 43.9 % of physicians correctly identified all diseases or conditions in a list associated or not with AATD. A similar trend was detected when identifying which conditions would be responsive to augmentation therapy (<50 %). Only 15.8 % of specialists performed AATD testing in all patients with COPD (27.0 % pulmonologists, 12.6 % PCP; p = 0.001). Conclusion The results suggest that a knowledge gap may be contributing to the underdiagnosis of AATD. Physicians in Spain and Portugal showed a marked lack of awareness of their shortcomings in knowledge about AATD, and in general did not follow guidelines and recommendations for AATD testing. Background: determining physicians' awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and expected number of patients diagnosed with this disease. This study was designed to assess the opinions on knowledge, practice pattern and attitude regarding AATD among physicians in Spain and Portugal. Methods: as online anonymous survey was performed on pulmonologists (n = 100), internal medicine specialists (IMS) (n = 100) and primary care physicians (PCP) (n = 176). Of the total number of physicians, 221 were from Spain, and 155 were from Portugal. Physicians answered 21 questions related to their personal and professional profile, knowledge regarding AATD and chronic obstructive pulmonary disease (COPD), performance and attitude about AATD, and use of augmentation therapy. Responses were ranked on a 4-point scale indicating the level of agreement. In addition, some of the responses were rated as either "low" or "high" indicating the level of knowledge the respondent felt he/she possessed. Results: only 14 % of physicians reported to "know very well" about AATD (3.3 [SD 0.6] for pulmonologists vs. 2.64 [SD 0.60] for IMS and 2.48 [SD 0.71] for PCP; p < 0.001). Only 45.2 % of physicians correctly answered "<50 mg/dL" as the threshold value of serum AAT to be considered severe AATD (55.0 % of pulmonologists vs. 47.0 % of IMS and 38.6 % of PCP; p = 0.001). Choice of the correct answer did not agree with those physicians self-declaring a high level of AATD knowledge (51.2 %). A total of 43.9 % of physicians correctly identified all diseases or conditions in a list associated or not with AATD. A similar trend was detected when identifying which conditions would be responsive to augmentation therapy (<50 %). Only 15.8 % of specialists performed AATD testing in all patients with COPD (27.0 % pulmonologists, 12.6 % PCP; p = 0.001). Conclusion: the results suggest that a knowledge gap may be contributing to the underdiagnosis of AATD. Physicians in Spain and Portugal showed a marked lack of awareness of their shortcomings in knowledge about AATD, and in general did not follow guidelines and recommendations for AATD testing. Background Determining physicians' awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and expected number of patients diagnosed with this disease. This study was designed to assess the opinions on knowledge, practice pattern and attitude regarding AATD among physicians in Spain and Portugal. Methods An online anonymous survey was performed on pulmonologists (n = 100), internal medicine specialists (IMS) (n = 100) and primary care physicians (PCP) (n = 176). Of the total number of physicians, 221 were from Spain, and 155 were from Portugal. Physicians answered 21 questions related to their personal and professional profile, knowledge regarding AATD and chronic obstructive pulmonary disease (COPD), performance and attitude about AATD, and use of augmentation therapy. Responses were ranked on a 4-point scale indicating the level of agreement. In addition, some of the responses were rated as either "low" or "high" indicating the level of knowledge the respondent felt he/she possessed. Results Only 14 % of physicians reported to "know very well" about AATD (3.3 [SD 0.6] for pulmonologists vs. 2.64 [SD 0.60] for IMS and 2.48 [SD 0.71] for PCP; p < 0.001). Only 45.2 % of physicians correctly answered "<50 mg/dL" as the threshold value of serum AAT to be considered severe AATD (55.0 % of pulmonologists vs. 47.0 % of IMS and 38.6 % of PCP; p = 0.001). Choice of the correct answer did not agree with those physicians self-declaring a high level of AATD knowledge (51.2 %). A total of 43.9 % of physicians correctly identified all diseases or conditions in a list associated or not with AATD. A similar trend was detected when identifying which conditions would be responsive to augmentation therapy (<50 %). Only 15.8 % of specialists performed AATD testing in all patients with COPD (27.0 % pulmonologists, 12.6 % PCP; p = 0.001). Conclusion The results suggest that a knowledge gap may be contributing to the underdiagnosis of AATD. Physicians in Spain and Portugal showed a marked lack of awareness of their shortcomings in knowledge about AATD, and in general did not follow guidelines and recommendations for AATD testing. Keywords: Clinical practice, Knowledge, Alpha-1 antitrypsin deficiency, Management Background Determining physicians’ awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and expected number of patients diagnosed with this disease. This study was designed to assess the opinions on knowledge, practice pattern and attitude regarding AATD among physicians in Spain and Portugal. Methods An online anonymous survey was performed on pulmonologists ( n = 100), internal medicine specialists (IMS) ( n = 100) and primary care physicians (PCP) ( n = 176). Of the total number of physicians, 221 were from Spain, and 155 were from Portugal. Physicians answered 21 questions related to their personal and professional profile, knowledge regarding AATD and chronic obstructive pulmonary disease (COPD), performance and attitude about AATD, and use of augmentation therapy. Responses were ranked on a 4-point scale indicating the level of agreement. In addition, some of the responses were rated as either “low” or “high” indicating the level of knowledge the respondent felt he/she possessed. Results Only 14 % of physicians reported to “know very well” about AATD (3.3 [SD 0.6] for pulmonologists vs. 2.64 [SD 0.60] for IMS and 2.48 [SD 0.71] for PCP; p < 0.001). Only 45.2 % of physicians correctly answered “<50 mg/dL” as the threshold value of serum AAT to be considered severe AATD (55.0 % of pulmonologists vs. 47.0 % of IMS and 38.6 % of PCP; p = 0.001). Choice of the correct answer did not agree with those physicians self-declaring a high level of AATD knowledge (51.2 %). A total of 43.9 % of physicians correctly identified all diseases or conditions in a list associated or not with AATD. A similar trend was detected when identifying which conditions would be responsive to augmentation therapy (<50 %). Only 15.8 % of specialists performed AATD testing in all patients with COPD (27.0 % pulmonologists, 12.6 % PCP; p = 0.001). Conclusion The results suggest that a knowledge gap may be contributing to the underdiagnosis of AATD. Physicians in Spain and Portugal showed a marked lack of awareness of their shortcomings in knowledge about AATD, and in general did not follow guidelines and recommendations for AATD testing. Determining physicians' awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and expected number of patients diagnosed with this disease. An online anonymous survey was performed on pulmonologists (n = 100), internal medicine specialists (IMS) (n = 100) and primary care physicians (PCP) (n = 176). Of the total number of physicians, 221 were from Spain, and 155 were from Portugal. Physicians answered 21 questions related to their personal and professional profile, knowledge regarding AATD and chronic obstructive pulmonary disease (COPD), performance and attitude about AATD, and use of augmentation therapy. Responses were ranked on a 4-point scale indicating the level of agreement. In addition, some of the responses were rated as either "low" or "high" indicating the level of knowledge the respondent felt he/she possessed. Only 14 % of physicians reported to "know very well" about AATD (3.3 [SD 0.6] for pulmonologists vs. 2.64 [SD 0.60] for IMS and 2.48 [SD 0.71] for PCP; p < 0.001). Only 45.2 % of physicians correctly answered "<50 mg/dL" as the threshold value of serum AAT to be considered severe AATD (55.0 % of pulmonologists vs. 47.0 % of IMS and 38.6 % of PCP; p = 0.001). Choice of the correct answer did not agree with those physicians self-declaring a high level of AATD knowledge (51.2 %). A total of 43.9 % of physicians correctly identified all diseases or conditions in a list associated or not with AATD. A similar trend was detected when identifying which conditions would be responsive to augmentation therapy (<50 %). Only 15.8 % of specialists performed AATD testing in all patients with COPD (27.0 % pulmonologists, 12.6 % PCP; p = 0.001). The results suggest that a knowledge gap may be contributing to the underdiagnosis of AATD. Physicians in Spain and Portugal showed a marked lack of awareness of their shortcomings in knowledge about AATD, and in general did not follow guidelines and recommendations for AATD testing. |
| ArticleNumber | 64 |
| Audience | Academic |
| Author | Barrecheguren, Miriam Miravitlles, Marc Sucena, Maria Esquinas, Cristina Rodriguez, Esther Fernandez, Sandra |
| Author_xml | – sequence: 1 givenname: Cristina surname: Esquinas fullname: Esquinas, Cristina organization: Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades Respiratorias (CIBERES) – sequence: 2 givenname: Miriam surname: Barrecheguren fullname: Barrecheguren, Miriam organization: Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades Respiratorias (CIBERES) – sequence: 3 givenname: Maria surname: Sucena fullname: Sucena, Maria organization: Pneumology Department, Centro Hospitalar de São João – sequence: 4 givenname: Esther surname: Rodriguez fullname: Rodriguez, Esther organization: Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades Respiratorias (CIBERES) – sequence: 5 givenname: Sandra surname: Fernandez fullname: Fernandez, Sandra organization: Scientific and Medical Affairs, Grifols – sequence: 6 givenname: Marc surname: Miravitlles fullname: Miravitlles, Marc email: mmiravitlles@vhebron.net organization: Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades Respiratorias (CIBERES) |
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| Cites_doi | 10.1164/ajrccm.158.1.9712017 10.1053/rmed.2000.0854 10.1159/000325067 10.1016/j.coph.2012.02.004 10.1016/j.arbres.2014.05.008 10.1157/13095974 10.1111/crj.12310 10.1016/j.rmed.2008.07.003 10.1016/j.rmed.2013.04.023 10.1016/0002-9343(83)90615-0 10.1164/rccm.168.7.818 10.1172/JCI110344 10.1002/art.27742 10.1007/s00508-010-1399-9 10.1183/09031936.06.00062305 10.1016/0022-1031(90)90073-U 10.1038/357605a0 10.1183/09031936.00069709 10.1289/ehp.6511 10.1016/0002-9343(88)90156-8 10.1177/1753465811404919 10.3109/15412555.2015.1021912 10.3109/15412555.2010.482577 10.1183/09031936.05.00007305 10.1378/chest.122.5.1818 10.1016/0304-4165(78)90083-1 |
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| References | F Huber (222_CR21) 2010; 122 B Lara (222_CR25) 2015; 12 DA Lomas (222_CR7) 1992; 357 RM Taliercio (222_CR27) 2010; 55 M Miravitlles (222_CR5) 2012; 12 The Alpha-1-Antitrypsin Deficiency Registry Study Group (222_CR9) 1998; 158 American Thoracic Society/European Respiratory Society statement (222_CR10) 2003; 168 EJ Campbell (222_CR18) 2000; 94 AD Mahr (222_CR11) 2010; 62 A Koj (222_CR1) 1978; 539 F Casas (222_CR14) 2015; 51 T Greulich (222_CR26) 2013; 107 L Fromer (222_CR28) 2010; 7 J Travis (222_CR6) 1988; 84 JD Brown (222_CR29) 1990; 26 L Corda (222_CR20) 2011; 82 222_CR19 FJ Serres de (222_CR2) 2002; 122 JE Gadek (222_CR4) 1981; 68 222_CR15 I Blanco (222_CR3) 2006; 27 C Roza de la (222_CR16) 2006; 42 J Molina (222_CR23) 2011; 5 FJ Serres de (222_CR24) 2003; 111 C Roza de la (222_CR17) 2005; 26 B Sitkauskiene (222_CR22) 2008; 102 DW Cox (222_CR8) 1983; 74 R Vidal (222_CR13) 2006; 42 M Miravitlles (222_CR12) 2010; 35 |
| References_xml | – volume: 158 start-page: 49 year: 1998 ident: 222_CR9 publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.158.1.9712017 – volume: 94 start-page: S18 issue: Suppl C year: 2000 ident: 222_CR18 publication-title: Respir Med doi: 10.1053/rmed.2000.0854 – volume: 82 start-page: 418 year: 2011 ident: 222_CR20 publication-title: Respiration doi: 10.1159/000325067 – volume: 12 start-page: 309 year: 2012 ident: 222_CR5 publication-title: Curr Opin Pharmacol doi: 10.1016/j.coph.2012.02.004 – volume: 51 start-page: 185 year: 2015 ident: 222_CR14 publication-title: Arch Bronconeumol doi: 10.1016/j.arbres.2014.05.008 – volume: 42 start-page: 645 year: 2006 ident: 222_CR13 publication-title: Arch Bronconeumol doi: 10.1157/13095974 – ident: 222_CR19 doi: 10.1111/crj.12310 – volume: 102 start-page: 1654 year: 2008 ident: 222_CR22 publication-title: Respir Med doi: 10.1016/j.rmed.2008.07.003 – volume: 107 start-page: 1400 year: 2013 ident: 222_CR26 publication-title: Respir Med doi: 10.1016/j.rmed.2013.04.023 – volume: 74 start-page: 221 year: 1983 ident: 222_CR8 publication-title: Am J Med doi: 10.1016/0002-9343(83)90615-0 – ident: 222_CR15 – volume: 168 start-page: 818 year: 2003 ident: 222_CR10 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.168.7.818 – volume: 68 start-page: 889 year: 1981 ident: 222_CR4 publication-title: J Clin Invest doi: 10.1172/JCI110344 – volume: 62 start-page: 3760 year: 2010 ident: 222_CR11 publication-title: Arthritis Rheum doi: 10.1002/art.27742 – volume: 122 start-page: 390 year: 2010 ident: 222_CR21 publication-title: Wien Klin Wochenschr doi: 10.1007/s00508-010-1399-9 – volume: 27 start-page: 77 year: 2006 ident: 222_CR3 publication-title: Eur Respir J doi: 10.1183/09031936.06.00062305 – volume: 26 start-page: 149 year: 1990 ident: 222_CR29 publication-title: J Exp Soc Psychol doi: 10.1016/0022-1031(90)90073-U – volume: 357 start-page: 605 year: 1992 ident: 222_CR7 publication-title: Nature doi: 10.1038/357605a0 – volume: 35 start-page: 960 year: 2010 ident: 222_CR12 publication-title: Eur Respir J doi: 10.1183/09031936.00069709 – volume: 111 start-page: 1851 year: 2003 ident: 222_CR24 publication-title: Environ Health Perspect doi: 10.1289/ehp.6511 – volume: 84 start-page: 37 year: 1988 ident: 222_CR6 publication-title: Am J Med doi: 10.1016/0002-9343(88)90156-8 – volume: 5 start-page: 237 year: 2011 ident: 222_CR23 publication-title: Ther Adv Respir Dis doi: 10.1177/1753465811404919 – volume: 12 start-page: 27 issue: Suppl 1 year: 2015 ident: 222_CR25 publication-title: COPD doi: 10.3109/15412555.2015.1021912 – volume: 55 start-page: 322 year: 2010 ident: 222_CR27 publication-title: Respir Care – volume: 7 start-page: 192 year: 2010 ident: 222_CR28 publication-title: COPD doi: 10.3109/15412555.2010.482577 – volume: 26 start-page: 616 year: 2005 ident: 222_CR17 publication-title: Eur Respir J doi: 10.1183/09031936.05.00007305 – volume: 122 start-page: 1818 year: 2002 ident: 222_CR2 publication-title: Chest doi: 10.1378/chest.122.5.1818 – volume: 42 start-page: 290 year: 2006 ident: 222_CR16 publication-title: Arch Bronconeumol – volume: 539 start-page: 496 year: 1978 ident: 222_CR1 publication-title: Biochim Biophys Acta doi: 10.1016/0304-4165(78)90083-1 |
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Determining physicians’ awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and... Background Determining physicians' awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and... Determining physicians' awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and expected... Background: determining physicians' awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and... |
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| SubjectTerms | Alpha 1-antitrypsin deficiency Chronic obstructive pulmonary disease Complications and side effects COPD and occupational lung disease Critical Care Medicine Diagnosis Diagnòstic Errors congènits del metabolisme Espanya Genetic diseases Inborn errors of metabolism Intensive Internal Medicine Laboratories Liver Liver diseases Lung diseases, Obstructive Malalties hereditàries Medical diagnosis Medical protocols Medicine Medicine & Public Health Pneumology/Respiratory System Portugal Protocols clínics Pulmonology Questionnaires Research Article Risk factors Spain Standard deviation Statistical analysis Studies Thoracic surgery |
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| Title | Practice and knowledge about diagnosis and treatment of alpha-1 antitrypsin deficiency in Spain and Portugal |
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