The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete a variety of proteins collectively known as the senescence-associated secretory phenotype (SASP), which can reinforce the arrest and induce senescence in a p...

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Bibliographic Details
Published in:	Genes & development Vol. 31; no. 2; p. 172
Main Authors:	Ritschka, Birgit, Storer, Mekayla, Mas, Alba, Heinzmann, Florian, Ortells, Mari Carmen, Morton, Jennifer P, Sansom, Owen J, Zender, Lars, Keyes, William M
Format:	Journal Article
Language:	English
Published:	United States 15.01.2017
Subjects:	Animals Biomarkers - metabolism Cell Plasticity - genetics Cell Plasticity - physiology Cells, Cultured Cellular Senescence - genetics Cellular Senescence - physiology Epithelial Cells - cytology Epithelial Cells - physiology Female Gene Deletion Gene Expression Regulation, Developmental - genetics Keratinocytes - cytology Keratinocytes - physiology Liver - cytology Liver - physiology Mice Mice, Inbred C57BL NF-kappa B - genetics Phenotype Regeneration - genetics Regeneration - physiology Secretory Pathway - genetics Secretory Pathway - physiology Stem Cells - metabolism senescence stem cells plasticity CD34 SASP papilloma
ISSN:	1549-5477, 1549-5477
Online Access:	Get more information
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