The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims

Zinc is one of the most important trace elements in our body. Patients suffering from depression show lower serum zinc levels compared to healthy controls. Zincs antagonism to the glutamatergic system seems to be responsible for mood recovery. Recent years have shown that zinc may regulate neurotran...

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Bibliographic Details
Published in:	Neuropharmacology Vol. 79; pp. 290 - 297
Main Authors:	Młyniec, Katarzyna, Doboszewska, Urszula, Szewczyk, Bernadeta, Sowa-Kućma, Magdalena, Misztak, Paulina, Piekoszewski, Wojciech, Trela, Franciszek, Ostachowicz, Beata, Nowak, Gabriel
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.04.2014
Subjects:	Adult Animals BDNF Brain-Derived Neurotrophic Factor - metabolism CREB Cyclic AMP Response Element-Binding Protein - metabolism Depression Depressive Disorder - metabolism Disease Models, Animal Female Frontal Lobe - metabolism GPR39 Hippocampus - metabolism Humans Male Mice Mice, Inbred Strains Olfactory Bulb - physiopathology Olfactory Bulb - surgery Rats Rats, Sprague-Dawley Receptor, trkB - metabolism Receptors, G-Protein-Coupled - metabolism Signal Transduction Suicide TrkB Zinc - deficiency Zn(2+)-sensing receptor GPR39 Zn(2+)-sensing receptor Depression TrkB CREB BDNF
ISSN:	0028-3908, 1873-7064, 1873-7064
Online Access:	Get full text
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