Transcriptomic Profiling of the Immune Response in Orthotopic Pancreatic Tumours Exposed to Combined Boiling Histotripsy and Oncolytic Reovirus Treatment

Background: Boiling histotripsy (BH) uses high-amplitude, short-pulse focused ultrasound to disrupt tissue mechanically. Oncolytic virotherapy using reovirus has shown modest clinical benefit in pancreatic cancer patients. Here, reovirus and BH were used to treat pancreatic tumours, and their effect...

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Veröffentlicht in:	Pharmaceutics Jg. 17; H. 8; S. 949
Hauptverfasser:	Mouratidis, Petros, Ferreira, Ricardo C., Anbalagan, Selvakumar, Chauhan, Ritika, Rivens, Ian, ter Haar, Gail
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 22.07.2025 MDPI
Schlagworte:	B cells Broadband transmission Cancer research Cancer therapies Cell death Chemokines Chemotherapy Cytokines focused ultrasound Histology histotripsy Immune response Immunotherapy Medical prognosis Medical research Metastasis Oncolytic viruses Pancreatic cancer reovirus T cells therapeutic ultrasound Tumors Ultrasonic imaging United Kingdom Washington, D.C United Kingdom > UK United States > US Oncolytic viruses therapeutic ultrasound pancreatic cancer TAP complex histotripsy reovirus immunotherapy focused ultrasound transcriptomic profiling
ISSN:	1999-4923, 1999-4923
Online-Zugang:	Volltext
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