High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer

The development of targeted therapies has created a pressing clinical need for the rapid and robust molecular characterisation of cancers. We describe here the application of high-resolution melting analysis (HRM) to screen for KRAS mutations in clinical cancer samples. In non-small cell lung cancer...

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Bibliographic Details

Published in:	BMC cancer Vol. 6; no. 1; p. 295
Main Authors:	Krypuy, Michael, Newnham, Genni M, Thomas, David M, Conron, Matthew, Dobrovic, Alexander
Format:	Journal Article
Language:	English
Published:	England BioMed Central 21.12.2006 BMC
Subjects:	Adenocarcinoma - genetics Carcinoma, Large Cell - genetics Carcinoma, Non-Small-Cell Lung - genetics Codon - genetics DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Humans Lung Neoplasms - genetics Mutation Nucleic Acid Denaturation Polymerase Chain Reaction Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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