The effect of casein and calcium containing paste on plaque pH following a subsequent carbohydrate challenge

Previous research has shown that regular use of CPP–ACP increases calcium and inorganic phosphates in plaque and reduces enamel mineral loss. The aim of this study was to investigate if a CPP–ACP-containing paste would neutralize acidic challenges in dental plaque following sucrose rinse. Plaque pH...

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Bibliographic Details
Published in:Journal of dentistry Vol. 37; no. 7; pp. 522 - 526
Main Authors: Caruana, Paul Chetcuti, Mulaify, Sami Al, Moazzez, Rebecca, Bartlett, David
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.07.2009
Elsevier Limited
Subjects:
Adult
Buffers
Cariogenic Agents - adverse effects
Cariostatic Agents - therapeutic use
Caseins - therapeutic use
CPP–ACP
Cross-Over Studies
Dental Plaque - physiopathology
Dentistry
Double-Blind Method
Female
Humans
Hydrogen-Ion Concentration
Ion-Selective Electrodes
Male
Measurement
Plaque pH
Sorbitol - adverse effects
Sucrose
Sucrose - adverse effects
Sweetening Agents - adverse effects
Time Factors
Toothpastes - therapeutic use
Measurement
pH
Sucrose
Plaque pH
CPP–ACP
ISSN:0300-5712, 1879-176X
Online Access:Get full text
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Summary:Previous research has shown that regular use of CPP–ACP increases calcium and inorganic phosphates in plaque and reduces enamel mineral loss. The aim of this study was to investigate if a CPP–ACP-containing paste would neutralize acidic challenges in dental plaque following sucrose rinse. Plaque pH was measured on 15 subjects in a cross-over study with and without prior application of the paste and with and without CPP–ACP. On each occasion, subjects rinsed with 10% sucrose and sorbitol solutions for 2 min in randomized order. The results showed the median lowest pH without paste was 4.8 (IQR: 4.7–5.0) and with mousse 5.6 (IQR: 5.5–5.6 and p < 0.001). The median lowest pH was 5.0 (IQR: 4.9–5.3) without CPP–ACP and with CPP–ACP was 5.8 (5.6–6.1 and p < 0.001). The time that pH remained below 5.7 and the time to return to resting pH showed similar differences in all subjects ( p < 0.01). The results indicate that prior application of a CPP–ACP-containing paste reduced the fall in plaque pH following a sucrose challenge.
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ISSN:0300-5712
1879-176X
DOI:10.1016/j.jdent.2009.03.010