Rifampicin and Isoniazid Maximal Concentrations are Below Efficacy-associated Thresholds in the Majority of Patients: Time to Increase the Doses?

•The majority of participants showed low rifampin and isoniazid plasmatic maximal concentrations at two early time points.•Ca. one-fifth of patients had suboptimal exposure to two or more drugs.•Higher doses/kg, being born in Italy, female gender, proton pump inhibitor use, and older age were among...

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Bibliographic Details
Published in:	International journal of antimicrobial agents Vol. 57; no. 3; p. 106297
Main Authors:	Trentalange, Alice, Borgogno, Enrica, Motta, Ilaria, Antonucci, Miriam, Pirriatore, Veronica, Costa, Cecilia, Rossi, Giovanni, Barco, Ambra, De Nicolò, Amedeo, Piccioni, Pavilio, D'Avolio, Antonio, Bonora, Stefano, Di Perri, Giovanni, Calcagno, Andrea
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.03.2021
Subjects:	Anti-tubercular drugs blood body mass index females Infectious Disease isoniazid Italy males observational studies Pharmacokinetics proton pump inhibitors regression analysis rifampicin Therapeutic drug monitoring therapeutics tuberculosis Italy Therapeutic drug monitoring Pharmacokinetics Anti-tubercular drugs
ISSN:	0924-8579, 1872-7913, 1872-7913
Online Access:	Get full text
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