Rifampicin and Isoniazid Maximal Concentrations are Below Efficacy-associated Thresholds in the Majority of Patients: Time to Increase the Doses?

•The majority of participants showed low rifampin and isoniazid plasmatic maximal concentrations at two early time points.•Ca. one-fifth of patients had suboptimal exposure to two or more drugs.•Higher doses/kg, being born in Italy, female gender, proton pump inhibitor use, and older age were among...

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