Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis in Opioid Dependent Subjects: Effects of Acute and Protracted Abstinence
Objectives: The function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between subjects during methadone stabilization and drug-free detoxification with healthy controls. Methods: Sixty heroin dependent patients receive...
Uloženo v:
| Vydáno v: | The American journal of drug and alcohol abuse Ročník 34; číslo 6; s. 760 - 768 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Colchester
Informa UK Ltd
01.01.2008
Taylor & Francis Taylor & Francis Ltd |
| Témata: | |
| ISSN: | 0095-2990, 1097-9891, 1097-9891 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Objectives: The function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between subjects during methadone stabilization and drug-free detoxification with healthy controls. Methods: Sixty heroin dependent patients received either non-opiate treatment (NOT) with benzodiazepines and clonidine (n = 30) or methadone stabilization treatment (MT, n = 30), and their serum levels of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol (COR) were measured and compared to those of healthy, nondependent controls. Results: Compared with healthy controls, CRH was significantly lower (p <. 001) while COR was higher (p <. 001) during acute withdrawal in the NOT group. CRH and COR was lower (p <. 001), while ACTH was normal in the MT group compared to healthy controls. Conclusions: Our findings suggest that chronic opioid dependence may cause reduced function of the HPA axis, while opioid withdrawal may decrease the response of the pituitary to CRH and increase the adrenal response to ACTH. |
|---|---|
| AbstractList | Objectives: The function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between subjects during methadone stabilization and drug-free detoxification with healthy controls. Methods: Sixty heroin dependent patients received either non-opiate treatment (NOT) with benzodiazepines and clonidine (n = 30) or methadone stabilization treatment (MT, n = 30), and their serum levels of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol (COR) were measured and compared to those of healthy, nondependent controls. Results: Compared with healthy controls, CRH was significantly lower (p < .001) while COR was higher (p < .001) during acute withdrawal in the NOT group. CRH and COR was lower (p < .001), while ACTH was normal in the MT group compared to healthy controls. Conclusions: Our findings suggest that chronic opioid dependence may cause reduced function of the HPA axis, while opioid withdrawal may decrease the response of the pituitary to CRH and increase the adrenal response to ACTH. The function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between subjects during methadone stabilization and drug-free detoxification with healthy controls.OBJECTIVESThe function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between subjects during methadone stabilization and drug-free detoxification with healthy controls.Sixty heroin dependent patients received either non-opiate treatment (NOT) with benzodiazepines and clonidine (n = 30) or methadone stabilization treatment (MT, n = 30), and their serum levels of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol (COR) were measured and compared to those of healthy, nondependent controls.METHODSSixty heroin dependent patients received either non-opiate treatment (NOT) with benzodiazepines and clonidine (n = 30) or methadone stabilization treatment (MT, n = 30), and their serum levels of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol (COR) were measured and compared to those of healthy, nondependent controls.Compared with healthy controls, CRH was significantly lower (p < .001) while COR was higher (p < .001) during acute withdrawal in the NOT group. CRH and COR was lower (p < .001), while ACTH was normal in the MT group compared to healthy controls.RESULTSCompared with healthy controls, CRH was significantly lower (p < .001) while COR was higher (p < .001) during acute withdrawal in the NOT group. CRH and COR was lower (p < .001), while ACTH was normal in the MT group compared to healthy controls.Our findings suggest that chronic opioid dependence may cause reduced function of the HPA axis, while opioid withdrawal may decrease the response of the pituitary to CRH and increase the adrenal response to ACTH.CONCLUSIONSOur findings suggest that chronic opioid dependence may cause reduced function of the HPA axis, while opioid withdrawal may decrease the response of the pituitary to CRH and increase the adrenal response to ACTH. The function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between subjects during methadone stabilization and drug-free detoxification with healthy controls. Sixty heroin dependent patients received either non-opiate treatment (NOT) with benzodiazepines and clonidine (n = 30) or methadone stabilization treatment (MT, n = 30), and their serum levels of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol (COR) were measured and compared to those of healthy, nondependent controls. Compared with healthy controls, CRH was significantly lower (p < .001) while COR was higher (p < .001) during acute withdrawal in the NOT group. CRH and COR was lower (p < .001), while ACTH was normal in the MT group compared to healthy controls. Our findings suggest that chronic opioid dependence may cause reduced function of the HPA axis, while opioid withdrawal may decrease the response of the pituitary to CRH and increase the adrenal response to ACTH. The function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between subjects during methadone stabilization and drug-free detoxification with healthy controls. Sixty heroin dependent patients received either non-opiate treatment (NOT) with benzodiazepines and clonidine (n = 30) or methadone stabilization treatment (MT, n = 30), and their serum levels of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol (COR) were measured and compared to those of healthy, nondependent controls. Compared with healthy controls, CRH was significantly lower (p < .001) while COR was higher (p < .001) during acute withdrawal in the NOT group. CRH and COR was lower (p < .001), while ACTH was normal in the MT group compared to healthy controls. Our findings suggest that chronic opioid dependence may cause reduced function of the HPA axis, while opioid withdrawal may decrease the response of the pituitary to CRH and increase the adrenal response to ACTH. Objectives: The function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between subjects during methadone stabilization and drug-free detoxification with healthy controls. Methods: Sixty heroin dependent patients received either non-opiate treatment (NOT) with benzodiazepines and clonidine (n = 30) or methadone stabilization treatment (MT, n = 30), and their serum levels of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol (COR) were measured and compared to those of healthy, nondependent controls. Results: Compared with healthy controls, CRH was significantly lower (p < .001) while COR was higher (p < .001) during acute withdrawal in the NOT group. CRH and COR was lower (p < .001), while ACTH was normal in the MT group compared to healthy controls. Conclusions: Our findings suggest that chronic opioid dependence may cause reduced function of the HPA axis, while opioid withdrawal may decrease the response of the pituitary to CRH and increase the adrenal response to ACTH. Adapted from the source document. |
| Author | Jiang, Zuo-Ning Xiao, Le Smith, Alicia K. Tang, Yi-Lang Liu, Zhen-Qi Ren, Yan-Ping Chi, Yong Du, Wan-Jun Luo, Xiao-Nian Zhang, Guo-Fu Zhang, Hong-Xi Sheng, Li-Xia Guo, Song |
| Author_xml | – sequence: 1 givenname: Guo-Fu surname: Zhang fullname: Zhang, Guo-Fu organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 2 givenname: Yan-Ping surname: Ren fullname: Ren, Yan-Ping organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 3 givenname: Li-Xia surname: Sheng fullname: Sheng, Li-Xia organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 4 givenname: Yong surname: Chi fullname: Chi, Yong organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 5 givenname: Wan-Jun surname: Du fullname: Du, Wan-Jun organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 6 givenname: Song surname: Guo fullname: Guo, Song organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 7 givenname: Zuo-Ning surname: Jiang fullname: Jiang, Zuo-Ning organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 8 givenname: Le surname: Xiao fullname: Xiao, Le organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 9 givenname: Xiao-Nian surname: Luo fullname: Luo, Xiao-Nian organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 10 givenname: Yi-Lang surname: Tang fullname: Tang, Yi-Lang organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 11 givenname: Alicia K. surname: Smith fullname: Smith, Alicia K. organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 12 givenname: Zhen-Qi surname: Liu fullname: Liu, Zhen-Qi organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China – sequence: 13 givenname: Hong-Xi surname: Zhang fullname: Zhang, Hong-Xi organization: 1Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20979951$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19016181$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFklFrFDEUhYNU7Lb6A3yRINi30WRmMjNRX5a2WqHQgvo83E1u2CyzyZpk0H3yrzfDbitWbF-SC_nOzeWce0QOnHdIyEvO3nLWsXeMSVFKmcuy6kTb8SdkxplsC9lJfkBm03sxAYfkKMYVY4x3bf2MHHLJeMM7PiO_z7bRjE4l6x31hqYl0ovtxqclDLC2qri2abQJwraY64AOBjr_ZSO1jl5trLeanuEGnUaX6NdxsUKV4nt6bsxUTA3nakxIwWl6HXwKoBJqOl_EZB06hc_JUwNDxBf7-5h8_3T-7fSiuLz6_OV0flkoUVap4LWSoEUjpAQlDMNaqEoazGXJG6gXC0BRQV0iik4brfMBZXbBKJ1dKKtjcrLruwn-x4gx9WsbFQ4DOPRj7BvZMdHV3aOgaMu2aph8FCyZaBrWTl-_vgeu_Biyk5nhsmpZU03dXu2hcbFG3W-CXWfT-9ukMvBmD0BUMJgATtl4x5U5dinFxLU7TgUfY0DTqxzfFG823w49Z_20O_0_u5OV_J7ybogHNB93GuuMD2v46cOg-wTbwYfbEauH5B_-ki8RhrRUEPCPR_9X3wA5b-pX |
| CODEN | AJDABD |
| CitedBy_id | crossref_primary_10_1016_j_psyneuen_2025_107570 crossref_primary_10_1038_s41398_024_03119_z crossref_primary_10_1007_s12035_021_02322_z crossref_primary_10_1016_j_bbr_2019_112041 crossref_primary_10_1016_j_drugalcdep_2009_07_022 crossref_primary_10_1016_j_mehy_2010_09_002 crossref_primary_10_1016_j_psychres_2020_113218 crossref_primary_10_1002_jnr_23913 crossref_primary_10_1016_j_acthis_2013_07_006 crossref_primary_10_1016_j_ajp_2021_102964 crossref_primary_10_1016_j_ajog_2016_05_041 crossref_primary_10_1016_j_psyneuen_2014_12_004 crossref_primary_10_1016_j_biopsych_2010_08_021 crossref_primary_10_1007_s00406_017_0809_7 crossref_primary_10_1007_s12325_014_0096_x crossref_primary_10_1515_rns_2011_011 crossref_primary_10_1016_j_ajog_2016_10_003 crossref_primary_10_1016_j_bbr_2009_12_004 crossref_primary_10_1016_j_cpr_2021_101978 crossref_primary_10_1038_s41398_021_01548_8 crossref_primary_10_1111_add_14732 crossref_primary_10_1177_0300060518779314 crossref_primary_10_1016_j_ejphar_2010_11_025 crossref_primary_10_1097_MS9_0000000000003010 crossref_primary_10_1016_j_sxmr_2018_04_003 crossref_primary_10_1016_j_jsat_2014_08_006 crossref_primary_10_3390_jcm14186662 crossref_primary_10_1080_02791072_2025_2550288 crossref_primary_10_1210_clinem_dgz022 crossref_primary_10_1371_journal_pone_0150729 crossref_primary_10_1016_j_neubiorev_2020_03_029 crossref_primary_10_1159_000496559 |
| Cites_doi | 10.1016/S0143-4179(03)00021-0 10.1177/000456320003700414 10.1046/j.1365-2826.2001.00713.x 10.1046/j.1365-2826.2001.00714.x 10.1016/S0076-6879(83)03040-2 10.1016/S0893-133X(00)00222-0 10.1023/A:1026499604848 10.1007/PL00005096 10.1111/j.1360-0443.2006.01367.x 10.1146/annurev.pa.33.040193.002033 10.1016/S0006-3223(03)00167-7 10.1300/J069v25n02_02 10.1016/S0304-3940(02)01036-4 10.2741/1966 |
| ContentType | Journal Article |
| Copyright | 2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008 2009 INIST-CNRS Copyright Marcel Dekker, Inc. Nov 2008 |
| Copyright_xml | – notice: 2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008 – notice: 2009 INIST-CNRS – notice: Copyright Marcel Dekker, Inc. Nov 2008 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7QJ 7U3 BHHNA K7. K9. 7TK 7U7 C1K 7X8 |
| DOI | 10.1080/00952990802385781 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Applied Social Sciences Index & Abstracts (ASSIA) Social Services Abstracts Sociological Abstracts ProQuest Criminal Justice (Alumni) ProQuest Health & Medical Complete (Alumni) Neurosciences Abstracts Toxicology Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) ProQuest Criminal Justice (Alumni) Social Services Abstracts Applied Social Sciences Index and Abstracts (ASSIA) Sociological Abstracts Toxicology Abstracts Neurosciences Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | Toxicology Abstracts MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) MEDLINE Applied Social Sciences Index and Abstracts (ASSIA) |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Social Welfare & Social Work |
| EISSN | 1097-9891 |
| EndPage | 768 |
| ExternalDocumentID | 1599322401 19016181 20979951 10_1080_00952990802385781 338745 |
| Genre | Research Article Research Support, Non-U.S. Gov't Journal Article Feature |
| GroupedDBID | --- .GJ 00X 03L 08R 0BK 0R~ 123 23M 2QV 34G 36B 39C 4.4 53G 5RE 5VS 6J9 AADGC AAJNR AALIY AALUX AAMIU AAPUL AAPXX AAQQT AAQRR AAWTL ABBKH ABDBF ABEIZ ABGNL ABIVO ABLCE ABLKL ABPTK ABUPF ACENM ACFUF ACGEJ ACGFO ACGOD ACHQT ACKFH ACKLR ACLSK ACVOX ADCVX ADFCX ADPSL ADRBQ ADVEQ ADXPE ADZJE AECIN AEIQB AENEX AEOZL AETHL AEYQI AFFNX AFKVX AFLJA AFWLO AGDLA AGFJD AGRBW AGXXK AGYJP AHMBA AI. AIAGR AIJEM AIKPT AIRBT AJWEG AKBVH ALIIL ALMA_UNASSIGNED_HOLDINGS ALQZU APIUT ASUFR AWYRJ BABNJ BLEHA BOHLJ BTKSN C1A CAG CCCUG COF COGVJ CS3 DKSSO DXH EAP EAS EBC EBD EBS EHN EJD EMB EMK EMOBN EPL EPS EPT ESI ESO ESX F5P FEDTE H13 HAMGP HZ~ H~9 KRBQP KSSTO KUULJ KWAYT KYCEM L7B LJTGL LSO M44 M4Z O9- P2P PQEST PQQKQ Q~Q RNANH RVRKI RWL SV3 TAE TFDNU TFL TFW TUS U5U V1S VH1 VQP WH7 X6Y XSW YYQ ZGI ZXP ~1N AAGDL ABLIJ ABUFD ABWVI ABXYU ACIEZ ACUHS ACWGZ AEDCE AFRVT ALYBC AQTUD HVGLF TASJS TBQAZ TDBHL TERGH TUROJ AAYXX CITATION ADYSH AELXL AEXKJ B0M IQODW AMPGV CGR CUY CVF ECM EIF NPM 7QJ 7U3 BHHNA K7. K9. 7TK 7U7 C1K 7X8 |
| ID | FETCH-LOGICAL-c523t-14c9ad56599ac5f0e45c39fe5f0216a4bbae53a42ee58dfdd8dfa2891fcd00923 |
| IEDL.DBID | TFW |
| ISICitedReferencesCount | 39 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000261018200011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0095-2990 1097-9891 |
| IngestDate | Thu Sep 04 20:06:23 EDT 2025 Thu Sep 04 18:35:50 EDT 2025 Thu Oct 30 07:46:07 EDT 2025 Tue Nov 11 12:12:31 EST 2025 Thu May 22 04:42:21 EDT 2025 Mon Mar 31 10:57:07 EDT 2025 Tue Nov 18 20:53:05 EST 2025 Sat Nov 29 05:55:07 EST 2025 Mon Oct 20 23:46:14 EDT 2025 Wed Jun 21 08:14:36 EDT 2023 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Hypothalamohypophysoadrenal axis Corticotropin releasing factor ACTH Opiates Cortisol HPA axis Hydrocortisone Glucocorticoid Dependence Hormone releasing factor Human Corticosteroid Drug addiction Steroid hormone Acute Substance abuse Abstinence Hypothalamic hormone Adrenocorticotropic hormone Adenohypophyseal hormone Addiction Dysfunction Adrenal hormone CRH opioid dependence |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c523t-14c9ad56599ac5f0e45c39fe5f0216a4bbae53a42ee58dfdd8dfa2891fcd00923 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| PMID | 19016181 |
| PQID | 219370639 |
| PQPubID | 48364 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_20566072 proquest_journals_219370639 informaworld_taylorfrancis_310_1080_00952990802385781 proquest_miscellaneous_57273609 pascalfrancis_primary_20979951 proquest_miscellaneous_69805848 pubmed_primary_19016181 informahealthcare_journals_10_1080_00952990802385781 crossref_citationtrail_10_1080_00952990802385781 crossref_primary_10_1080_00952990802385781 |
| PublicationCentury | 2000 |
| PublicationDate | 2008-01-01 |
| PublicationDateYYYYMMDD | 2008-01-01 |
| PublicationDate_xml | – month: 01 year: 2008 text: 2008-01-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Colchester |
| PublicationPlace_xml | – name: Colchester – name: England – name: New York |
| PublicationTitle | The American journal of drug and alcohol abuse |
| PublicationTitleAlternate | Am J Drug Alcohol Abuse |
| PublicationYear | 2008 |
| Publisher | Informa UK Ltd Taylor & Francis Taylor & Francis Ltd |
| Publisher_xml | – name: Informa UK Ltd – name: Taylor & Francis – name: Taylor & Francis Ltd |
| References | Nava F (CIT0013) 2006; 25 Kennedy D M (CIT0008) 2000; 37 Ziolkowska A (CIT0007) 2003; 11 Houshyar H (CIT0002) 2001; 13 CIT0012 Kanchev L N (CIT0011) 2006; 9 Jiang Z N (CIT0005) 1995 Milanes M V (CIT0016) 2002; 334 Maj M (CIT0015) 2003; 37 Hinz B (CIT0017) 2000; 17 Vale W (CIT0006) 1983; 103 CIT0014 Schluger J H (CIT0004) 2001; 24 CIT0018 Houshyar H (CIT0001) 2001; 13 CIT0009 Gerra G (CIT0003) 2003; 18 Milanes M V (CIT0010) 1997; 356 |
| References_xml | – volume: 37 start-page: 105 issue: 2 year: 2003 ident: CIT0015 publication-title: Neuropeptides doi: 10.1016/S0143-4179(03)00021-0 – volume: 37 start-page: 520 year: 2000 ident: CIT0008 publication-title: Ann Clin Biochem doi: 10.1177/000456320003700414 – volume: 13 start-page: 862 issue: 10 year: 2001 ident: CIT0002 publication-title: J Neuroendocrinol doi: 10.1046/j.1365-2826.2001.00713.x – volume: 9 start-page: 257 issue: 4 year: 2006 ident: CIT0011 publication-title: Bulgarian J Veterinary Medicine – volume: 13 start-page: 875 issue: 10 year: 2001 ident: CIT0001 publication-title: J Neuroendocrinol doi: 10.1046/j.1365-2826.2001.00714.x – volume: 103 start-page: 565 year: 1983 ident: CIT0006 publication-title: Methods Enzymol doi: 10.1016/S0076-6879(83)03040-2 – volume: 24 start-page: 568 issue: 5 year: 2001 ident: CIT0004 publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(00)00222-0 – volume: 11 start-page: 613 issue: 5 year: 2003 ident: CIT0007 publication-title: Int J Mol Med – volume: 17 start-page: 1273 issue: 10 year: 2000 ident: CIT0017 publication-title: Pharm Res doi: 10.1023/A:1026499604848 – volume: 356 start-page: 603 issue: 5 year: 1997 ident: CIT0010 publication-title: Naunyn Schmiedebergs Arch Pharmacol doi: 10.1007/PL00005096 – volume-title: Heroin Addiction and Contemporary Treatments, 1st Ed year: 1995 ident: CIT0005 – ident: CIT0009 doi: 10.1111/j.1360-0443.2006.01367.x – ident: CIT0014 doi: 10.1146/annurev.pa.33.040193.002033 – ident: CIT0012 doi: 10.1016/S0006-3223(03)00167-7 – volume: 25 start-page: 9 issue: 2 year: 2006 ident: CIT0013 publication-title: J Addictive Diseases doi: 10.1300/J069v25n02_02 – volume: 334 start-page: 58 issue: 1 year: 2002 ident: CIT0016 publication-title: Neurosci Lett doi: 10.1016/S0304-3940(02)01036-4 – volume: 18 start-page: 261 issue: 5 year: 2003 ident: CIT0003 publication-title: Int Clin Psychopharmacol – ident: CIT0018 doi: 10.2741/1966 |
| SSID | ssj0001874 |
| Score | 2.0098069 |
| Snippet | Objectives: The function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between... The function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between subjects... |
| SourceID | proquest pubmed pascalfrancis crossref informaworld informahealthcare |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 760 |
| SubjectTerms | ACTH Addictive behaviors Adrenocorticotropic Hormone - blood Adult Adult and adolescent clinical studies Benzodiazepines Benzodiazepines - therapeutic use Biological and medical sciences Clonidine Clonidine - therapeutic use Comparative analysis Corticotropin-Releasing Hormone - blood Cortisol CRH Detoxification Drug addiction Drug dependency Drug replacement therapy Drug therapy Female Heroin Heroin Dependence - physiopathology Heroin Dependence - rehabilitation Hormones HPA axis Humans Hydrocortisone - blood Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - physiopathology Male Medical sciences Medical treatment Methadone Methadone - therapeutic use opioid dependence Opioids Patients Pituitary gland Pituitary-Adrenal System - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serum Stabilization Substance Withdrawal Syndrome - physiopathology Treatment Young Adult |
| Title | Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis in Opioid Dependent Subjects: Effects of Acute and Protracted Abstinence |
| URI | https://www.tandfonline.com/doi/abs/10.1080/00952990802385781 https://www.ncbi.nlm.nih.gov/pubmed/19016181 https://www.proquest.com/docview/219370639 https://www.proquest.com/docview/20566072 https://www.proquest.com/docview/57273609 https://www.proquest.com/docview/69805848 |
| Volume | 34 |
| WOSCitedRecordID | wos000261018200011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAWR databaseName: Taylor & Francis Journals Complete customDbUrl: eissn: 1097-9891 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001874 issn: 0095-2990 databaseCode: TFW dateStart: 19740101 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LbxMxELag4sCFlndoCT4gDkgr9r1rbhEl6gGVHArNbeWnWBHtRmunIqf-9c7sq7TQHOASRcnYsr2fx5_t2W8IeSsBFCxQzBMhnlZlofZymQsvU4YFwmgVtTe6379kp6f5cskWfWyO7cMqcQ9tOqGI1lfj5ObCDhFxH5AWoBdF7bIcEIebH2D1iO-z-fnohzHbXKdBmXhoPtxp_q2GG6vSQa9Z-mOMwLqlY4oBlNzCGJou-cXd7LRdpeb7_9m_A_Kop6d01uHpMbmnqyfkqHuHl57rlYFm0nd0-KFufj4ll8dbi8sjPmJaGwqUkp5s1wABvsJs996idJvS8WbrzfC9caz_V2lpWdGv67IuFT3uM_E6Cn4MD4bsR9rJKluscCY3TlPoDl00tWv1pRWdCXBOFfqlZ-Tb_PPZpxOvz-vgSdj2Oi-IJeMKmCRjXCbG13EiI2Y0fA2DlMdCcJ1EPA61TnJllIIPDhvDwEiFGlHRc7JX1ZV-SahWscxSroGWCKCeOudBhqVYEPqZFGJC_OG5FrIXPcfcG6siGLVRbw32hLwfi6w7xY9dxvEfYCl6L2B3FUt-x1Ph2tOZHk1FtKPc9AbwxgaGPl7PJmBwOCDxuhmwKEUZUtEJeTP-C14Er4Z4pesNmAAPTv0svNsiQaKb-jvqSFnuA53NJ-RFNwWuh4-1eRmCV__Y7UPysAvTwZOvI7Lnmo1-TR7IC1faZkruZ8t82s79K4PlVM4 |
| linkProvider | Taylor & Francis |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwELbQggQXWN5ll10fEAcki7ycxNwqlqqIUnoo7N4ixw8RUSVVkiJ64q8zk9eyrx7gEkXJ2LKd8fjzePINIa8UKIVwtWCph96qyDMsVnHKIm2Fm1qj_eZE99ssms_jszOx6BxuVRdWiXto2xJFNLYaJzc6o_uQuLeIC9CMInlZDCoHu5_bAAM4Tszl5HSwxJhvrmWh5Azl-1PN66q4sC7td6yl34cYrEtMphhCKSsYRdumv7gZnzbr1OTB__Zwn9zvECodtyr1kNwy-SNy2P7GS0_NykI76WvaPyjKH4_J75NthSskfmVaWAqokk63a9ACucKE92yR1ZusluWWjfHXcaz_V1bRLKdf1lmRaXrSJeOtKZgy9A1V72jLrFxhhWO1qQ2F_tBFWdQNxbSm4xTsU46m6Qn5OvmwfD9lXWoHpmDnWzM3UEJqAJNCSMWtYwKufGEN3HpuKIM0lYb7MvCM4bG2WsNFwt7QtUojTZT_lOzlRW6eE2p0oKJQGkAmKaBPE0s3wlLC9ZxIpemIOP2HTVTHe47pN1aJO9CjXhrsEXkzFFm3pB-7hIMr2pJ0hqDaVYz_rVBJ3ThoOnVK_B3lji5o3tBAz8ETWg4CB70qnjcD1iU_QjQ6IsfDWzAkeDokc1NsQASgcOhE3s0SHLFu6OyoIxSxA4g2HpFn7Rw4Hz7RpGZwX_zbaB2Tu9Pl51ky-zj_dEDutUE76Ac7JHt1uTEvyR31s86q8qixAH8AFpBXmQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZQQYgLlPfSlw-IA1JE3om5rbpdFVEteyi0t8jxQ41YJavEW3VP_HVmEielLd0DXKJVdmw5zufxZ3vyDSHvBYCCeZI5uY-7VYmvnFSkuZNIzbxcKxm0J7o_TpLZLD0_Z3Mbm9PYsEpcQ-tOKKL11Ti4l1L3EXGfkBagF0XtshQQB4ufh7ELwAM4n07PBkeM6eY6EcrIQfv-UPNvVdyYlrataOnFEIJ1S8gUIyh5A52ou-wX99PTdpqaPvvPB9wmTy0_peMOUM_JA1W-ILvdR7z0TC00NJN-oP2Nqv75kvyarBucH_Ed00pT4JT0eL0EDPAFprt35oVZFYbXa2eMH45j_VdFQ4uSflsWVSHpxKbiNRQcGe4MNZ9pp6vcYIVjsTKKwuPQeV2ZVmBa0nEO3qlEx_SKfJ8enR4eOzaxgyNg3WscLxSMS6CSjHERaVeFkQiYVvDT92Ie5jlXUcBDX6kolVpKuHBYGXpaSBSJCl6TrbIq1VtClQxFEnMFvCQH7qlS7iVYinm-m4g8HxG3f6-ZsKrnmHxjkXmDOOqtzh6Rj0ORZSf5sck4vAOWzLqBZlOx6E88ZabdnrFoyoIN5fZvAG9ooO_i-WwEBjs9Eq-bAbNSkCAXHZGD4V9wI3g2xEtVrcAEiHDsJv79FhEy3djdUEfMUhf4bDoib7ohcN19rE3M4L37t946II_nk2l28mX2dYc86SJ2cBNsl2yZeqX2yCNxaYqm3m_H_2_eU1ZR |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dysfunction+of+the+Hypothalamic-Pituitary-Adrenal+Axis+in+Opioid+Dependent+Subjects%3A+Effects+of+Acute+and+Protracted+Abstinence&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.au=Zhang%2C+Guo-Fu&rft.au=Ren%2C+Yan-Ping&rft.au=Sheng%2C+Li-Xia&rft.au=Chi%2C+Yong&rft.date=2008-01-01&rft.pub=Informa+UK+Ltd&rft.issn=0095-2990&rft.eissn=1097-9891&rft.volume=34&rft.issue=6&rft.spage=760&rft.epage=768&rft_id=info:doi/10.1080%2F00952990802385781&rft.externalDocID=10_1080_00952990802385781 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0095-2990&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0095-2990&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0095-2990&client=summon |