Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects

Autism is a severe neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic mechanisms may partially contribute to the pathogenesis of this disorder. Cathepsin D is the predominant lysosomal protease and is...

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Vydáno v:	Neuroscience Ročník 165; číslo 2; s. 363 - 370
Hlavní autoři:	Sheikh, A.M., Li, X., Wen, G., Tauqeer, Z., Brown, W.T., Malik, M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Amsterdam Elsevier Ltd 20.01.2010 Elsevier
Témata:	Adolescent apoptosis autism Autistic Disorder - metabolism Bcl-2 Biological and medical sciences Blotting, Western Brain - metabolism Caspase 3 - metabolism caspase-3 cathepsin D Cathepsin D - metabolism Cerebellum - metabolism Child Child, Preschool Female Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology Hippocampus - metabolism Humans Immunohistochemistry inflammation Male Neurology Neurons - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Vertebrates: nervous system and sense organs Bcl-2 TGF IL cathepsin D inflammation apoptosis TNF autism caspase-3 tumor necrosis factor interleukin transforming growth factor Human Enzyme Cysteine endopeptidases Central nervous system Caspase Inflammation Protein Encephalon Peptidases Cell death Hydrolases Aspartic endopeptidases Cathepsin D Apoptosis
ISSN:	0306-4522, 1873-7544, 1873-7544
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