Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects

Autism is a severe neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic mechanisms may partially contribute to the pathogenesis of this disorder. Cathepsin D is the predominant lysosomal protease and is...

Full description

Saved in:

Bibliographic Details
Published in:	Neuroscience Vol. 165; no. 2; pp. 363 - 370
Main Authors:	Sheikh, A.M., Li, X., Wen, G., Tauqeer, Z., Brown, W.T., Malik, M.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 20.01.2010 Elsevier
Subjects:	Adolescent apoptosis autism Autistic Disorder - metabolism Bcl-2 Biological and medical sciences Blotting, Western Brain - metabolism Caspase 3 - metabolism caspase-3 cathepsin D Cathepsin D - metabolism Cerebellum - metabolism Child Child, Preschool Female Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology Hippocampus - metabolism Humans Immunohistochemistry inflammation Male Neurology Neurons - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Vertebrates: nervous system and sense organs Bcl-2 TGF IL cathepsin D inflammation apoptosis TNF autism caspase-3 tumor necrosis factor interleukin transforming growth factor Human Enzyme Cysteine endopeptidases Central nervous system Caspase Inflammation Protein Encephalon Peptidases Cell death Hydrolases Aspartic endopeptidases Cathepsin D Apoptosis
ISSN:	0306-4522, 1873-7544, 1873-7544
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!