Genes from a translational analysis support a multifactorial nature of white matter hyperintensities

White matter hyperintensities (WMH) of presumed vascular origin increase the risk of stroke and dementia. Despite strong WMH heritability, few gene associations have been identified. Relevant experimental models may be informative. We tested the associations between genes that were differentially ex...

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Veröffentlicht in:	Stroke (1970) Jg. 46; H. 2; S. 341
Hauptverfasser:	Lopez, Lorna M, Hill, W David, Harris, Sarah E, Valdes Hernandez, Maria, Munoz Maniega, Susana, Bastin, Mark E, Bailey, Emma, Smith, Colin, McBride, Martin, McClure, John, Graham, Delyth, Dominiczak, Anna, Yang, Qiong, Fornage, Myriam, Ikram, M Arfan, Debette, Stephanie, Launer, Lenore, Bis, Joshua C, Schmidt, Reinhold, Seshadri, Sudha, Porteous, David J, Starr, John, Deary, Ian J, Wardlaw, Joanna M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2015
Schlagworte:	Aged Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - genetics Animals Brain - pathology Causality Dementia - diagnosis Dementia - epidemiology Dementia - genetics Female Genome-Wide Association Study - methods Humans Leukoencephalopathies - diagnosis Leukoencephalopathies - epidemiology Leukoencephalopathies - genetics Male Polymorphism, Single Nucleotide - genetics Rats Rats, Inbred SHR Rats, Wistar Risk Factors Translational Research, Biomedical - methods White Matter - pathology magnetic resonance imaging genetics leukoencephalopathies humans
ISSN:	1524-4628, 1524-4628
Online-Zugang:	Weitere Angaben
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