Genes from a translational analysis support a multifactorial nature of white matter hyperintensities

White matter hyperintensities (WMH) of presumed vascular origin increase the risk of stroke and dementia. Despite strong WMH heritability, few gene associations have been identified. Relevant experimental models may be informative. We tested the associations between genes that were differentially ex...

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Vydáno v:	Stroke (1970) Ročník 46; číslo 2; s. 341
Hlavní autoři:	Lopez, Lorna M, Hill, W David, Harris, Sarah E, Valdes Hernandez, Maria, Munoz Maniega, Susana, Bastin, Mark E, Bailey, Emma, Smith, Colin, McBride, Martin, McClure, John, Graham, Delyth, Dominiczak, Anna, Yang, Qiong, Fornage, Myriam, Ikram, M Arfan, Debette, Stephanie, Launer, Lenore, Bis, Joshua C, Schmidt, Reinhold, Seshadri, Sudha, Porteous, David J, Starr, John, Deary, Ian J, Wardlaw, Joanna M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.02.2015
Témata:	Aged Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - genetics Animals Brain - pathology Causality Dementia - diagnosis Dementia - epidemiology Dementia - genetics Female Genome-Wide Association Study - methods Humans Leukoencephalopathies - diagnosis Leukoencephalopathies - epidemiology Leukoencephalopathies - genetics Male Polymorphism, Single Nucleotide - genetics Rats Rats, Inbred SHR Rats, Wistar Risk Factors Translational Research, Biomedical - methods White Matter - pathology magnetic resonance imaging genetics leukoencephalopathies humans
ISSN:	1524-4628, 1524-4628
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