Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects

Our objective was to execute a prospective cohort study to determine relationships between plasma mtDNA DAMP levels and the occurrence of systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and mortality. Mitochondrial DNA damage-associated molecular patterns...

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Bibliographic Details
Published in:	Annals of surgery Vol. 258; no. 4; p. 591
Main Authors:	Simmons, Jon D, Lee, Yann-Leei, Mulekar, Sujata, Kuck, Jamie L, Brevard, Sidney B, Gonzalez, Richard P, Gillespie, Mark N, Richards, William O
Format:	Journal Article
Language:	English
Published:	United States 01.10.2013
Subjects:	Adult Aged Aged, 80 and over Biomarkers - blood Cohort Studies Cyclooxygenase 1 - blood Cyclooxygenase 1 - genetics DNA, Mitochondrial - blood Female Genetic Markers Humans Injury Severity Score Male Middle Aged Multiple Organ Failure - blood Multiple Organ Failure - diagnosis Multiple Organ Failure - etiology Multiple Organ Failure - mortality NADH Dehydrogenase - blood NADH Dehydrogenase - genetics Prognosis Prospective Studies Real-Time Polymerase Chain Reaction Systemic Inflammatory Response Syndrome - blood Systemic Inflammatory Response Syndrome - diagnosis Systemic Inflammatory Response Syndrome - etiology Systemic Inflammatory Response Syndrome - mortality Wounds and Injuries - blood Wounds and Injuries - complications Wounds and Injuries - mortality
ISSN:	1528-1140, 1528-1140
Online Access:	Get more information
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