Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation

Background- APC is an antithrombotic and antiinflammatory serine protease that plays an important role in vascular function. We report that APC can suppress the proapoptotic mediator TRAIL in human umbilical vein endothelial cells, and we have investigated the signaling mechanism. APC inhibited endo...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology Jg. 27; H. 12; S. 2634
Hauptverfasser:	O'Brien, Lee A, Richardson, Mark A, Mehrbod, Sean F, Berg, David T, Gerlitz, Bruce, Gupta, Akanksha, Grinnell, Brian W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.12.2007
Schlagworte:	Antigens, CD - genetics Antigens, CD - metabolism Cells, Cultured Cytoprotection Early Growth Response Protein 1 - metabolism Endothelial Cells - enzymology Endothelial Cells - metabolism Endothelial Protein C Receptor Enzyme Activation Humans Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Protein C - metabolism Receptor, PAR-1 - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Lysosphingolipid - metabolism RNA Interference RNA, Messenger - metabolism RNA, Small Interfering - metabolism Signal Transduction Time Factors TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism Transcription, Genetic Tumor Necrosis Factor-alpha - metabolism
ISSN:	1524-4636, 1524-4636
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