New strategies to improve minimap2 alignment accuracy

Abstract Summary We present several recent improvements to minimap2, a versatile pairwise aligner for nucleotide sequences. Now minimap2 v2.22 can more accurately map long reads to highly repetitive regions and align through insertions or deletions up to 100 kb by default, addressing major weakness...

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Bibliographic Details
Published in:Bioinformatics Vol. 37; no. 23; pp. 4572 - 4574
Main Author: Li, Heng
Format: Journal Article
Language:English
Published: England Oxford University Press 07.12.2021
Subjects:
Algorithms
Applications Notes
Base Sequence
Sequence Analysis, DNA
Software
ISSN:1367-4803, 1367-4811, 1460-2059, 1367-4811
Online Access:Get full text
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Summary:Abstract Summary We present several recent improvements to minimap2, a versatile pairwise aligner for nucleotide sequences. Now minimap2 v2.22 can more accurately map long reads to highly repetitive regions and align through insertions or deletions up to 100 kb by default, addressing major weakness in minimap2 v2.18 or earlier. Availability and implementation https://github.com/lh3/minimap2.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1367-4803
1367-4811
1460-2059
1367-4811
DOI:10.1093/bioinformatics/btab705