Antimicrobial resistance and putative virulence genes of Pseudomonas aeruginosa isolates from patients with respiratory tract infection
is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly life-threatening manifestations in patients who are immunocompromised of who have cystic fibrosis. This study investigated the occurrence of extended-spectrum β-lactamases (ESBLs) and metallo...
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| Vydáno v: | Germs (Bucureşti) Ročník 8; číslo 1; s. 31 - 40 |
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| Jazyk: | angličtina |
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Romania
Asociatia pentru Cresterea Vizibilitatii Cercetarii Stiintifice (ACVCS)
01.03.2018
European HIV/AIDS and Infectious Diseases Academy Asociația pentru Creşterea Vizibilității Cercetării Ştiințifice (ACVCS) |
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| ISSN: | 2248-2997, 2248-2997 |
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| Abstract | is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly life-threatening manifestations in patients who are immunocompromised of who have cystic fibrosis. This study investigated the occurrence of extended-spectrum β-lactamases (ESBLs) and metallo β-lactamase (MBL) in association with important putative virulence genes and genotypes variation among
isolates from respiratory tract infection of Jordanian patients.
Over a period of 8-month, a total of 284 respiratory tract samples were obtained from patients diagnosed with respiratory tract infection while attending the Pulmonary Clinic/Intensive Care Unit, Jordan University Hospital (JUH). At the time of sampling most were inpatients (86.9%). Samples were cultured specifically for
.
A total of 61/284 (21.5%)
isolates were recovered from respiratory samples of patients. The percentage of MDR
isolates was 52.5%, and all isolates were susceptible to colistin with lower rates of susceptibility to other tested antibiotics. Positive genes of
,
,
,
and
were detected in 68.9%, 18.9%, 18.9%, 15.6% and 12.5% of isolates, respectively. Genotyping revealed no significant genetic relationship among MDR
isolates from hospitalized patients as judged by the constructed dendrogram and the presence of 14 genotypic groups. The percentages of the virulence genes
,
,
,
, and
among
isolates were 98%, 98%, 80%, 33% and 33%, respectively, and 87% of isolates produced pyocyanin.
The present study demonstrates high occurrence of MDR
isolates carrying
genes. No specific associations were found between antibiotic resistance, virulence genes and genotypes among MDR isolates. |
|---|---|
| AbstractList | Pseudomonas aeruginosa is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly life-threatening manifestations in patients who are immunocompromised of who have cystic fibrosis. This study investigated the occurrence of extended-spectrum β-lactamases (ESBLs) and metallo β-lactamase (MBL) in association with important putative virulence genes and genotypes variation among P. aeruginosa isolates from respiratory tract infection of Jordanian patients. Over a period of 8-month, a total of 284 respiratory tract samples were obtained from patients diagnosed with respiratory tract infection while attending the Pulmonary Clinic/Intensive Care Unit, Jordan University Hospital (JUH). At the time of sampling most were inpatients (86.9%). Samples were cultured specifically for P. aeruginosa. A total of 61/284 (21.5%) P. aeruginosa isolates were recovered from respiratory samples of patients. The percentage of MDR P. aeruginosa isolates was 52.5%, and all isolates were susceptible to colistin with lower rates of susceptibility to other tested antibiotics. Positive genes of b/aCTX-M, blaVEB, b/aTEM, blaGES and blaSHV were detected in 68.9%, 18.9%, 18.9%, 15.6% and 12.5% of isolates, respectively. Genotyping revealed no significant genetic relationship among MDR P. aeruginosa isolates from hospitalized patients as judged by the constructed dendrogram and the presence of 14 genotypic groups. The percentages of the virulence genes algD, lasB, toxA, exoS, and exoU among P. aeruginosa isolates were 98%, 98%, 80%, 33% and 33%, respectively, and 87% of isolates produced pyocyanin. The present study demonstrates high occurrence of MDR P. aeruginosa isolates carrying blaCTX.M genes. No specific associations were found between antibiotic resistance, virulence genes and genotypes among MDR isolates. Pseudomonas aeruginosa is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly life-threatening manifestations in patients who are immunocompromised of who have cystic fibrosis. This study investigated the occurrence of extended-spectrum β-lactamases (ESBLs) and metallo β-lactamase (MBL) in association with important putative virulence genes and genotypes variation among P. aeruginosa isolates from respiratory tract infection of Jordanian patients.INTRODUCTIONPseudomonas aeruginosa is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly life-threatening manifestations in patients who are immunocompromised of who have cystic fibrosis. This study investigated the occurrence of extended-spectrum β-lactamases (ESBLs) and metallo β-lactamase (MBL) in association with important putative virulence genes and genotypes variation among P. aeruginosa isolates from respiratory tract infection of Jordanian patients.Over a period of 8-month, a total of 284 respiratory tract samples were obtained from patients diagnosed with respiratory tract infection while attending the Pulmonary Clinic/Intensive Care Unit, Jordan University Hospital (JUH). At the time of sampling most were inpatients (86.9%). Samples were cultured specifically for P. aeruginosa.METHODSOver a period of 8-month, a total of 284 respiratory tract samples were obtained from patients diagnosed with respiratory tract infection while attending the Pulmonary Clinic/Intensive Care Unit, Jordan University Hospital (JUH). At the time of sampling most were inpatients (86.9%). Samples were cultured specifically for P. aeruginosa.A total of 61/284 (21.5%) P. aeruginosa isolates were recovered from respiratory samples of patients. The percentage of MDR P. aeruginosa isolates was 52.5%, and all isolates were susceptible to colistin with lower rates of susceptibility to other tested antibiotics. Positive genes of blaCTX-M, blaVEB, blaTEM, blaGES and blaSHV were detected in 68.9%, 18.9%, 18.9%, 15.6% and 12.5% of isolates, respectively. Genotyping revealed no significant genetic relationship among MDR P. aeruginosa isolates from hospitalized patients as judged by the constructed dendrogram and the presence of 14 genotypic groups. The percentages of the virulence genes algD, lasB, toxA, exoS, and exoU among P. aeruginosa isolates were 98%, 98%, 80%, 33% and 33%, respectively, and 87% of isolates produced pyocyanin.RESULTSA total of 61/284 (21.5%) P. aeruginosa isolates were recovered from respiratory samples of patients. The percentage of MDR P. aeruginosa isolates was 52.5%, and all isolates were susceptible to colistin with lower rates of susceptibility to other tested antibiotics. Positive genes of blaCTX-M, blaVEB, blaTEM, blaGES and blaSHV were detected in 68.9%, 18.9%, 18.9%, 15.6% and 12.5% of isolates, respectively. Genotyping revealed no significant genetic relationship among MDR P. aeruginosa isolates from hospitalized patients as judged by the constructed dendrogram and the presence of 14 genotypic groups. The percentages of the virulence genes algD, lasB, toxA, exoS, and exoU among P. aeruginosa isolates were 98%, 98%, 80%, 33% and 33%, respectively, and 87% of isolates produced pyocyanin.The present study demonstrates high occurrence of MDR P. aeruginosa isolates carrying blaCTX-M genes. No specific associations were found between antibiotic resistance, virulence genes and genotypes among MDR isolates.CONCLUSIONThe present study demonstrates high occurrence of MDR P. aeruginosa isolates carrying blaCTX-M genes. No specific associations were found between antibiotic resistance, virulence genes and genotypes among MDR isolates. Introduction Pseudomonas aeruginosa is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly life-threatening manifestations in patients who are immunocompromised of who have cystic fibrosis. This study investigated the occurrence of extended-spectrum [beta]-lactamases (ESBLs) and metallo [beta]-lactamase (MBL) in association with important putative virulence genes and genotypes variation among P. aeruginosa isolates from respiratory tract infection of Jordanian patients. Methods Over a period of 8-month, a total of 284 respiratory tract samples were obtained from patients diagnosed with respiratory tract infection while attending the Pulmonary Clinic/Intensive Care Unit, Jordan University Hospital (JUH). At the time of sampling most were inpatients (86.9%). Samples were cultured specifically for P. aeruginosa. Results A total of 61/284 (21.5%) P. aeruginosa isolates were recovered from respiratory samples of patients. The percentage of MDR P. aeruginosa isolates was 52.5%, and all isolates were susceptible to colistin with lower rates of susceptibility to other tested antibiotics. Positive genes of [bla.sub.CTX-M], [bla.sub.VEB], [bla.sub.TEM], [bla.sub.GES] and [bla.sub.SHV] were detected in 68.9%, 18.9%, 18.9%, 15.6% and 12.5% of isolates, respectively. Genotyping revealed no significant genetic relationship among MDR P. aeruginosa isolates from hospitalized patients as judged by the constructed dendrogram and the presence of 14 genotypic groups. The percentages of the virulence genes algD, lasB, toxA, exoS, and exoU among P. aeruginosa isolates were 98%, 98%, 80%, 33% and 33%, respectively, and 87% of isolates produced pyocyanin. Conclusion The present study demonstrates high occurrence of MDR P. aeruginosa isolates carrying [bla.sub.CTX-M] genes. No specific associations were found between antibiotic resistance, virulence genes and genotypes among MDR isolates. Keywords P. aeruginosa, antimicrobial resistance, virulence factors, respiratory infections, Jordan patients. is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly life-threatening manifestations in patients who are immunocompromised of who have cystic fibrosis. This study investigated the occurrence of extended-spectrum β-lactamases (ESBLs) and metallo β-lactamase (MBL) in association with important putative virulence genes and genotypes variation among isolates from respiratory tract infection of Jordanian patients. Over a period of 8-month, a total of 284 respiratory tract samples were obtained from patients diagnosed with respiratory tract infection while attending the Pulmonary Clinic/Intensive Care Unit, Jordan University Hospital (JUH). At the time of sampling most were inpatients (86.9%). Samples were cultured specifically for . A total of 61/284 (21.5%) isolates were recovered from respiratory samples of patients. The percentage of MDR isolates was 52.5%, and all isolates were susceptible to colistin with lower rates of susceptibility to other tested antibiotics. Positive genes of , , , and were detected in 68.9%, 18.9%, 18.9%, 15.6% and 12.5% of isolates, respectively. Genotyping revealed no significant genetic relationship among MDR isolates from hospitalized patients as judged by the constructed dendrogram and the presence of 14 genotypic groups. The percentages of the virulence genes , , , , and among isolates were 98%, 98%, 80%, 33% and 33%, respectively, and 87% of isolates produced pyocyanin. The present study demonstrates high occurrence of MDR isolates carrying genes. No specific associations were found between antibiotic resistance, virulence genes and genotypes among MDR isolates. |
| Audience | Academic |
| Author | Abu-Qatouseh, Luay F Al Dawodeyah, Heba Y Shehabi, Asem A Obeidat, Nathir |
| AuthorAffiliation | 1 MSc, Department of Pathology-Microbiology, School of Medicine, The Jordan University, Queen Rania str. 100, Amman, Jordan 4 DSc, Department of Pathology-Microbiology, School of Medicine, The Jordan University, Queen Rania str. 100, Amman, Jordan 2 MD, Department of Internal Medicine/Division of Pulmonary Diseases, The Jordan University Hospital, Queen Rania str. 100, Amman, Jordan 3 PhD, Faculty of Pharmacy, Department of Biomedical Sciences, University of Petra, Airport str. 317, Amman, Jordan |
| AuthorAffiliation_xml | – name: 2 MD, Department of Internal Medicine/Division of Pulmonary Diseases, The Jordan University Hospital, Queen Rania str. 100, Amman, Jordan – name: 1 MSc, Department of Pathology-Microbiology, School of Medicine, The Jordan University, Queen Rania str. 100, Amman, Jordan – name: 3 PhD, Faculty of Pharmacy, Department of Biomedical Sciences, University of Petra, Airport str. 317, Amman, Jordan – name: 4 DSc, Department of Pathology-Microbiology, School of Medicine, The Jordan University, Queen Rania str. 100, Amman, Jordan |
| Author_xml | – sequence: 1 givenname: Heba Y surname: Al Dawodeyah fullname: Al Dawodeyah, Heba Y – sequence: 2 givenname: Nathir surname: Obeidat fullname: Obeidat, Nathir – sequence: 3 givenname: Luay F surname: Abu-Qatouseh fullname: Abu-Qatouseh, Luay F – sequence: 4 givenname: Asem A surname: Shehabi fullname: Shehabi, Asem A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29564246$$D View this record in MEDLINE/PubMed |
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| Snippet | is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly life-threatening manifestations in patients who are... Introduction Pseudomonas aeruginosa is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly... Pseudomonas aeruginosa is a common agent causing community acquired and nosocomial respiratory tract infections, with particularly life-threatening... |
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| SubjectTerms | Antimicrobial agents Bacterial infections Genes Genetic aspects Health aspects Infectious diseases Microbial drug resistance Original Patient outcomes Pseudomonas aeruginosa Pseudomonas aeruginosa infections Respiratory system Risk factors |
| Title | Antimicrobial resistance and putative virulence genes of Pseudomonas aeruginosa isolates from patients with respiratory tract infection |
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