HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial oxidative phosphorylation (OXPHOS) when oxygen is available. Most cancer cells, on the other hand, are known to produce energy predominantly through accelerated glycolysis, followed by lactic acid fermentation even und...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 20; no. 2; p. 238
Main Authors:	Nagao, Ayako, Kobayashi, Minoru, Koyasu, Sho, Chow, Christalle C. T., Harada, Hiroshi
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 09.01.2019 MDPI
Subjects:	Animals Cancer Cellular Reprogramming - genetics Dehydrogenases Enzymes Fermentation Gene expression Glucose Glucose - metabolism Glycolysis Humans Hypoxia Hypoxia - genetics Hypoxia - metabolism Hypoxia-Inducible Factor 1 - genetics Hypoxia-Inducible Factor 1 - metabolism Kinases Metabolic Networks and Pathways Metabolism Metabolites Mitochondria - genetics Mitochondria - metabolism Mutation Oxidative Phosphorylation Proteins Radiation Tolerance - genetics Review Sulfur Transcription factors HIF-1 hypoxia cancer glucose metabolism
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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