Single-cell transcriptomic profiling of heart reveals ANGPTL4 linking fibroblasts and angiogenesis in heart failure with preserved ejection fraction

[Display omitted] •We characterized the transcriptional landscape of non-cardiomyocytes in HFpEF hearts using scRNA-seq and bulk RNA-seq.•Fibroblasts in the HFpEF heart might cross-link with the EC lineages via over-secretion of ANGPTL4.•We predicted ANGPTL4 as a potential druggable target using Dru...

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Bibliographic Details
Published in:	Journal of advanced research Vol. 68; pp. 215 - 230
Main Authors:	Li, Guoxing, Zhao, Huilin, Cheng, Zhe, Liu, Junjin, Li, Gang, Guo, Yongzheng
Format:	Journal Article
Language:	English
Published:	Egypt Elsevier B.V 01.02.2025 Elsevier
Subjects:	Angiogenesis Angiopoietin-Like Protein 4 - genetics Angiopoietin-Like Protein 4 - metabolism ANGPTL4 Animals Disease Models, Animal Endothelial Cells - metabolism Fibroblasts - metabolism Fibroblasts - pathology Fibrosis Gene Expression Profiling Heart Failure - genetics Heart Failure - metabolism Heart Failure - pathology Heart Failure - physiopathology HFpEF Humans Male Metabolism Mice Mice, Inbred C57BL Myocardium - metabolism Myocardium - pathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Physiologic - genetics Original Manuscript scRNA-seq Single-Cell Analysis - methods Single-Cell Gene Expression Analysis - methods Stroke Volume - physiology Transcriptome Angiogenesis scRNA-seq HFpEF ANGPTL4 Metabolism
ISSN:	2090-1232, 2090-1224, 2090-1224
Online Access:	Get full text
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