Glucose and Leucine Metabolism in Lung Tranplanted Patients on Low Dose of Steroids for Immunosuppressive Therapy
This study examined the metabolic effects of lung transplantation in patients with end-stage respiratory failure on low dose of steroids for immunosuppressive therapy. We examined 6 patients, including 2 women and 4 men of overall mean age 53 ± 15 years and age at transplantation 34 ± 12 months, rec...
Uloženo v:
| Vydáno v: | Transplantation proceedings Ročník 40; číslo 5; s. 1566 - 1571 |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
New York, NY
Elsevier Inc
01.06.2008
Elsevier Science |
| Témata: | |
| ISSN: | 0041-1345, 1873-2623 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | This study examined the metabolic effects of lung transplantation in patients with end-stage respiratory failure on low dose of steroids for immunosuppressive therapy.
We examined 6 patients, including 2 women and 4 men of overall mean age 53 ± 15 years and age at transplantation 34 ± 12 months, receiving cyclosporine 5.73 ± 1.43 mg/kg/d or tacrolimus (FK 506) 4.67 ± 0.58 mg/d, azathioprine 0.47 ± 0.29 mg/kg/d, and prednisone 8.25 mg/d for comparison with 6 healthy subjects, who were selected to be comparable to the recipients in terms of anthropometric features and age. A euglycemic hyperinsulinemic clamp (1 mU/kg/min) associated with infusion of glucose and leucine isotopes was performed with indirect calorimetry.
Lung transplanted patients showed postabsorptive leucine and free fatty acid metabolism similar to controls. In contrast, there was peripheral insulin resistance with respect to glucose metabolism namely, higher values of glucose and insulin vs controls (
P < .03 and
P < .02, respectively). During the clamp the metabolic picture was characterized by a relative insulin resistance with respect to glucose metabolism (
P = .07). Lipid and protein metabolism in the basal and insulin-stimulated conditions were similar to the control group.
In the basal condition insulin resistance is evident with respect to glucose metabolism. The metabolic picture in lung transplanted patients on low-dose steroid therapy was characterized by normal insulin-stimulated glucose, leucine, and free fatty acid metabolism. The minimal metabolic alterations in these patients were not due to transplantation itself but probably mainly attributable to immunosuppressive therapy. |
|---|---|
| AbstractList | This study examined the metabolic effects of lung transplantation in patients with end-stage respiratory failure on low dose of steroids for immunosuppressive therapy.BACKGROUNDThis study examined the metabolic effects of lung transplantation in patients with end-stage respiratory failure on low dose of steroids for immunosuppressive therapy.We examined 6 patients, including 2 women and 4 men of overall mean age 53 +/- 15 years and age at transplantation 34 +/- 12 months, receiving cyclosporine 5.73 +/- 1.43 mg/kg/d or tacrolimus (FK 506) 4.67 +/- 0.58 mg/d, azathioprine 0.47 +/- 0.29 mg/kg/d, and prednisone 8.25 mg/d for comparison with 6 healthy subjects, who were selected to be comparable to the recipients in terms of anthropometric features and age. A euglycemic hyperinsulinemic clamp (1 mU/kg/min) associated with infusion of glucose and leucine isotopes was performed with indirect calorimetry.METHODSWe examined 6 patients, including 2 women and 4 men of overall mean age 53 +/- 15 years and age at transplantation 34 +/- 12 months, receiving cyclosporine 5.73 +/- 1.43 mg/kg/d or tacrolimus (FK 506) 4.67 +/- 0.58 mg/d, azathioprine 0.47 +/- 0.29 mg/kg/d, and prednisone 8.25 mg/d for comparison with 6 healthy subjects, who were selected to be comparable to the recipients in terms of anthropometric features and age. A euglycemic hyperinsulinemic clamp (1 mU/kg/min) associated with infusion of glucose and leucine isotopes was performed with indirect calorimetry.Lung transplanted patients showed postabsorptive leucine and free fatty acid metabolism similar to controls. In contrast, there was peripheral insulin resistance with respect to glucose metabolism namely, higher values of glucose and insulin vs controls (P < .03 and P < .02, respectively). During the clamp the metabolic picture was characterized by a relative insulin resistance with respect to glucose metabolism (P = .07). Lipid and protein metabolism in the basal and insulin-stimulated conditions were similar to the control group.RESULTSLung transplanted patients showed postabsorptive leucine and free fatty acid metabolism similar to controls. In contrast, there was peripheral insulin resistance with respect to glucose metabolism namely, higher values of glucose and insulin vs controls (P < .03 and P < .02, respectively). During the clamp the metabolic picture was characterized by a relative insulin resistance with respect to glucose metabolism (P = .07). Lipid and protein metabolism in the basal and insulin-stimulated conditions were similar to the control group.In the basal condition insulin resistance is evident with respect to glucose metabolism. The metabolic picture in lung transplanted patients on low-dose steroid therapy was characterized by normal insulin-stimulated glucose, leucine, and free fatty acid metabolism. The minimal metabolic alterations in these patients were not due to transplantation itself but probably mainly attributable to immunosuppressive therapy.CONCLUSIONSIn the basal condition insulin resistance is evident with respect to glucose metabolism. The metabolic picture in lung transplanted patients on low-dose steroid therapy was characterized by normal insulin-stimulated glucose, leucine, and free fatty acid metabolism. The minimal metabolic alterations in these patients were not due to transplantation itself but probably mainly attributable to immunosuppressive therapy. Abstract Background This study examined the metabolic effects of lung transplantation in patients with end-stage respiratory failure on low dose of steroids for immunosuppressive therapy. Methods We examined 6 patients, including 2 women and 4 men of overall mean age 53 ± 15 years and age at transplantation 34 ± 12 months, receiving cyclosporine 5.73 ± 1.43 mg/kg/d or tacrolimus (FK 506) 4.67 ± 0.58 mg/d, azathioprine 0.47 ± 0.29 mg/kg/d, and prednisone 8.25 mg/d for comparison with 6 healthy subjects, who were selected to be comparable to the recipients in terms of anthropometric features and age. A euglycemic hyperinsulinemic clamp (1 mU/kg/min) associated with infusion of glucose and leucine isotopes was performed with indirect calorimetry. Results Lung transplanted patients showed postabsorptive leucine and free fatty acid metabolism similar to controls. In contrast, there was peripheral insulin resistance with respect to glucose metabolism namely, higher values of glucose and insulin vs controls ( P < .03 and P < .02, respectively). During the clamp the metabolic picture was characterized by a relative insulin resistance with respect to glucose metabolism ( P = .07). Lipid and protein metabolism in the basal and insulin-stimulated conditions were similar to the control group. Conclusions In the basal condition insulin resistance is evident with respect to glucose metabolism. The metabolic picture in lung transplanted patients on low-dose steroid therapy was characterized by normal insulin-stimulated glucose, leucine, and free fatty acid metabolism. The minimal metabolic alterations in these patients were not due to transplantation itself but probably mainly attributable to immunosuppressive therapy. This study examined the metabolic effects of lung transplantation in patients with end-stage respiratory failure on low dose of steroids for immunosuppressive therapy. We examined 6 patients, including 2 women and 4 men of overall mean age 53 ± 15 years and age at transplantation 34 ± 12 months, receiving cyclosporine 5.73 ± 1.43 mg/kg/d or tacrolimus (FK 506) 4.67 ± 0.58 mg/d, azathioprine 0.47 ± 0.29 mg/kg/d, and prednisone 8.25 mg/d for comparison with 6 healthy subjects, who were selected to be comparable to the recipients in terms of anthropometric features and age. A euglycemic hyperinsulinemic clamp (1 mU/kg/min) associated with infusion of glucose and leucine isotopes was performed with indirect calorimetry. Lung transplanted patients showed postabsorptive leucine and free fatty acid metabolism similar to controls. In contrast, there was peripheral insulin resistance with respect to glucose metabolism namely, higher values of glucose and insulin vs controls ( P < .03 and P < .02, respectively). During the clamp the metabolic picture was characterized by a relative insulin resistance with respect to glucose metabolism ( P = .07). Lipid and protein metabolism in the basal and insulin-stimulated conditions were similar to the control group. In the basal condition insulin resistance is evident with respect to glucose metabolism. The metabolic picture in lung transplanted patients on low-dose steroid therapy was characterized by normal insulin-stimulated glucose, leucine, and free fatty acid metabolism. The minimal metabolic alterations in these patients were not due to transplantation itself but probably mainly attributable to immunosuppressive therapy. This study examined the metabolic effects of lung transplantation in patients with end-stage respiratory failure on low dose of steroids for immunosuppressive therapy. We examined 6 patients, including 2 women and 4 men of overall mean age 53 +/- 15 years and age at transplantation 34 +/- 12 months, receiving cyclosporine 5.73 +/- 1.43 mg/kg/d or tacrolimus (FK 506) 4.67 +/- 0.58 mg/d, azathioprine 0.47 +/- 0.29 mg/kg/d, and prednisone 8.25 mg/d for comparison with 6 healthy subjects, who were selected to be comparable to the recipients in terms of anthropometric features and age. A euglycemic hyperinsulinemic clamp (1 mU/kg/min) associated with infusion of glucose and leucine isotopes was performed with indirect calorimetry. Lung transplanted patients showed postabsorptive leucine and free fatty acid metabolism similar to controls. In contrast, there was peripheral insulin resistance with respect to glucose metabolism namely, higher values of glucose and insulin vs controls (P < .03 and P < .02, respectively). During the clamp the metabolic picture was characterized by a relative insulin resistance with respect to glucose metabolism (P = .07). Lipid and protein metabolism in the basal and insulin-stimulated conditions were similar to the control group. In the basal condition insulin resistance is evident with respect to glucose metabolism. The metabolic picture in lung transplanted patients on low-dose steroid therapy was characterized by normal insulin-stimulated glucose, leucine, and free fatty acid metabolism. The minimal metabolic alterations in these patients were not due to transplantation itself but probably mainly attributable to immunosuppressive therapy. |
| Author | Terruzzi, I. Benedini, S. Ruffini, E. Luzi, L. Mancuso, M. |
| Author_xml | – sequence: 1 givenname: S. surname: Benedini fullname: Benedini, S. organization: Clinical Research, Unit II, Department of Medicine, Istituto Scientifico H San Raffaele Milan, Milan Italy – sequence: 2 givenname: E. surname: Ruffini fullname: Ruffini, E. organization: Department of Thoracic Surgery, University of Torino, Torino, Italy – sequence: 3 givenname: I. surname: Terruzzi fullname: Terruzzi, I. organization: Clinical Research, Unit II, Department of Medicine, Istituto Scientifico H San Raffaele Milan, Milan Italy – sequence: 4 givenname: M. surname: Mancuso fullname: Mancuso, M. organization: Department of Thoracic Surgery, University of Torino, Torino, Italy – sequence: 5 givenname: L. surname: Luzi fullname: Luzi, L. email: luzi.livio@hsr.it organization: Clinical Research, Unit II, Department of Medicine, Istituto Scientifico H San Raffaele Milan, Milan Italy |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20492801$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18589153$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNklGL1DAUhYOsuLOrf0GCoG-tN0nbSX0QdVfXhRGFHZ9Dmt5qxjbpJu3K_HszzLjIgjBPIeTck3vPd8_IifMOCXnBIGfAqtebfAraxTF4g9jmHEDmIHKQ8hFZMLkUGa-4OCELgIJlTBTlKTmLcQPpzgvxhJwyWcqalWJBbq_62fiIVLuWrnA21iH9gpNufG_jQK2jq9n9oOv049hrN2FLv-nJopsi9enR_6aXu3rf0ZsJg7dtpJ0P9HoYZufjPI4BY7R3SNc_Mehx-5Q87nQf8dnhPCffP31cX3zOVl-vri_erzJTcj5ltUlNasal6IoKWNuARMSqlfUSjCwZgGmbojFVKUzdQCmgkNg1jRBN0xWlEefk1d435XQ7Y5zUYKPBPg2Bfo6qqvmyrFidhM8PwrkZsFVjsIMOW_U3pCR4eRDoaHTfpSiMjfc6DkXNJbCke7fXmeBjDNgpY6eUlXeJl-0VA7XjpzbqX35qx0-BUIlfsnjzwOK-m2OKL_fFmGK9sxhUNAmUwdYGNJNqvT3O5u0DG9NbZ9Pkv3CLcePn4BI4xVTkCtTNbst2SwYSQIAsksGH_xsc28UfX0vrRA |
| CODEN | TRPPA8 |
| CitedBy_id | crossref_primary_10_1155_2015_967562 crossref_primary_10_1007_s00592_018_1141_z |
| Cites_doi | 10.2337/diabetes.41.12.1632 10.1093/ajcn.81.2.421 10.1097/01.TP.0000065177.18714.2E 10.2337/diabetes.46.6.1001 10.1111/j.1749-6632.1959.tb44923.x 10.1021/ja00440a030 10.1056/NEJM199904083401406 10.1016/0003-2697(87)90236-3 10.1016/S0041-1345(98)00463-1 10.1681/ASN.V131213 10.1007/BF00404143 10.1016/j.healun.2004.02.022 10.1093/ajcn/76.3.541 10.1054/clnu.2002.0561 10.1183/09031936.03.00039003 10.1016/j.ccm.2004.04.008 10.1172/JCI118710 10.1172/JCI119609 10.1016/0026-0495(82)90160-3 10.1183/09031936.03.00039203 10.1056/NEJM199009133231101 10.1016/S1043-0679(98)70037-1 10.1002/hep.510310320 10.2337/diacare.25.3.530 10.1097/00007890-199109000-00026 |
| ContentType | Journal Article |
| Copyright | 2008 Elsevier Inc. Elsevier Inc. 2008 INIST-CNRS |
| Copyright_xml | – notice: 2008 Elsevier Inc. – notice: Elsevier Inc. – notice: 2008 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.transproceed.2008.03.088 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Biology Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1873-2623 |
| EndPage | 1571 |
| ExternalDocumentID | 18589153 20492801 10_1016_j_transproceed_2008_03_088 S0041134508003084 1_s2_0_S0041134508003084 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 123 1B1 1P~ 1~. 1~5 29Q 3O- 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABFRF ABJNI ABLJU ABMAC ABMZM ABOCM ABWVN ABXDB ACDAQ ACGFO ACIEU ACIUM ACLOT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGHFR AGQPQ AGUBO AGYEJ AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W J5H K-O KOM L7B M41 MO0 N9A O-L O9- OAUVE OK- OW- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSZ T5K UDS WH7 X7M XPP Y6R Z5R ZGI ZXP ~G- ~HD AACTN AFCTW AFKWA AJOXV AMFUW RIG AAIAV ABLVK ABYKQ AHPSJ AJBFU LCYCR ZA5 9DU AAYXX CITATION AGCQF AGRNS IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c522t-9c185a1283f4601db08eee6d8970c85100cdb4bc653c9b053048efbb33bbf45c3 |
| ISICitedReferencesCount | 2 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000257695300074&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0041-1345 |
| IngestDate | Sun Sep 28 06:58:31 EDT 2025 Wed Feb 19 01:43:16 EST 2025 Mon Jul 21 09:13:02 EDT 2025 Sat Nov 29 06:28:35 EST 2025 Tue Nov 18 21:52:01 EST 2025 Fri Feb 23 02:33:25 EST 2024 Sun Feb 23 10:19:46 EST 2025 Tue Oct 14 19:30:55 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Human Steroid Corticosteroid Low dose Lung Patient Transplantation Glucose Leucine Metabolism Respiratory system Medicine Treatment Aminoacid Surgery Graft Immunosuppressive agent Pharmacokinetics |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c522t-9c185a1283f4601db08eee6d8970c85100cdb4bc653c9b053048efbb33bbf45c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 18589153 |
| PQID | 69275619 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_69275619 pubmed_primary_18589153 pascalfrancis_primary_20492801 crossref_citationtrail_10_1016_j_transproceed_2008_03_088 crossref_primary_10_1016_j_transproceed_2008_03_088 elsevier_sciencedirect_doi_10_1016_j_transproceed_2008_03_088 elsevier_clinicalkeyesjournals_1_s2_0_S0041134508003084 elsevier_clinicalkey_doi_10_1016_j_transproceed_2008_03_088 |
| PublicationCentury | 2000 |
| PublicationDate | 2008-06-01 |
| PublicationDateYYYYMMDD | 2008-06-01 |
| PublicationDate_xml | – month: 06 year: 2008 text: 2008-06-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States |
| PublicationTitle | Transplantation proceedings |
| PublicationTitleAlternate | Transplant Proc |
| PublicationYear | 2008 |
| Publisher | Elsevier Inc Elsevier Science |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier Science |
| References | Perseghin, Mazzaferro, Benedini (bib19) 2002; 76 Luzi, Battezzati, Perseghin (bib16) 1992; 41 Ricordi, Zeng, Alejandro (bib26) 1991; 52 Arcasoy, Kotloff (bib1) 1999; 8340 Luzi, Piceni Sereni, Battezzati (bib22) 2003; 75 Sauerwein, Schols (bib7) 2002; 21 Lu, Bhorade (bib4) 2004; 25 (bib9) 1998; 21 Steele (bib17) 1959; 82 Luzi, Secchi, Facchini (bib11) 1990; 33 van Duijnhoven, Christiaans, Boots (bib25) 2002; 13 Glanville, Estenne (bib6) 2003; 22 Perseghin, Baratti, Benedini (bib24) 1998; 30 Matthews, Schwarz, Yang (bib18) 1982; 31 Matthews, Pesola, Campbell (bib14) 1990; 258 Reichenspurner (bib3) 2005; 24 Rafii, Chapman, Stewart (bib28) 2005; 8 Brillon, Zheng, Campbell (bib13) 1995; 268 Knoop, Haverich, Fischer (bib2) 2004; 23 Wiecko, Sherman (bib12) 1976; 98 Anderson, Zaharevitz, Strong (bib15) 1987; 163 Perseghin, Ghosh, Gerow (bib29) 1997; 46 Perseghin, Mazzaferro, Sereni (bib23) 2000; 31 Scherrer, Vissing, Morgan (bib27) 1990; 323 Perseghin, Regalia, Battezzati (bib10) 1997; 100 Benedini, Fiocchi, Battezzati (bib20) 2002; 25 Waddell, Keshavjee (bib5) 1998; 10 Luzi, Hering, Socci (bib21) 1996; 97 Hjalmarsen, Aasebo, Birkeland (bib8) 1996; 22 Steele (10.1016/j.transproceed.2008.03.088_bib17) 1959; 82 Luzi (10.1016/j.transproceed.2008.03.088_bib16) 1992; 41 Luzi (10.1016/j.transproceed.2008.03.088_bib21) 1996; 97 Perseghin (10.1016/j.transproceed.2008.03.088_bib23) 2000; 31 Ricordi (10.1016/j.transproceed.2008.03.088_bib26) 1991; 52 Scherrer (10.1016/j.transproceed.2008.03.088_bib27) 1990; 323 van Duijnhoven (10.1016/j.transproceed.2008.03.088_bib25) 2002; 13 Lu (10.1016/j.transproceed.2008.03.088_bib4) 2004; 25 Brillon (10.1016/j.transproceed.2008.03.088_bib13) 1995; 268 Perseghin (10.1016/j.transproceed.2008.03.088_bib10) 1997; 100 Knoop (10.1016/j.transproceed.2008.03.088_bib2) 2004; 23 Hjalmarsen (10.1016/j.transproceed.2008.03.088_bib8) 1996; 22 Luzi (10.1016/j.transproceed.2008.03.088_bib22) 2003; 75 Matthews (10.1016/j.transproceed.2008.03.088_bib14) 1990; 258 Reichenspurner (10.1016/j.transproceed.2008.03.088_bib3) 2005; 24 Perseghin (10.1016/j.transproceed.2008.03.088_bib19) 2002; 76 Perseghin (10.1016/j.transproceed.2008.03.088_bib24) 1998; 30 Arcasoy (10.1016/j.transproceed.2008.03.088_bib1) 1999; 8340 Glanville (10.1016/j.transproceed.2008.03.088_bib6) 2003; 22 Luzi (10.1016/j.transproceed.2008.03.088_bib11) 1990; 33 Wiecko (10.1016/j.transproceed.2008.03.088_bib12) 1976; 98 Matthews (10.1016/j.transproceed.2008.03.088_bib18) 1982; 31 Anderson (10.1016/j.transproceed.2008.03.088_bib15) 1987; 163 (10.1016/j.transproceed.2008.03.088_bib9) 1998; 21 Perseghin (10.1016/j.transproceed.2008.03.088_bib29) 1997; 46 Rafii (10.1016/j.transproceed.2008.03.088_bib28) 2005; 8 Waddell (10.1016/j.transproceed.2008.03.088_bib5) 1998; 10 Sauerwein (10.1016/j.transproceed.2008.03.088_bib7) 2002; 21 Benedini (10.1016/j.transproceed.2008.03.088_bib20) 2002; 25 |
| References_xml | – volume: 31 start-page: 1105 year: 1982 ident: bib18 article-title: Relationship of plasma leucine and α-ketoisocaproate during a L-[1- publication-title: Metabolism – volume: 33 start-page: 549 year: 1990 ident: bib11 article-title: Reduction of insulin resistance by combined kidney–pancreas transplantation in type 1 (insulin-dependent) diabetic patients publication-title: Diabetologia – volume: 21 start-page: 367 year: 2002 ident: bib7 article-title: Glucose metabolism in chronic lung disease publication-title: Clin Nutr – volume: 98 start-page: 7631 year: 1976 ident: bib12 article-title: Boroacetylation of carbohydrates: correlations between structure and mass spectral behavior in monoacetylhexose cyclic boronic esters publication-title: J Am Chem Soc – volume: 30 start-page: 1868 year: 1998 ident: bib24 article-title: Effect of liver transplantation in cirrhotic-diabetic patients publication-title: Transplant Proc – volume: 46 start-page: 1001 year: 1997 ident: bib29 article-title: Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study publication-title: Diabetes – volume: 8340 start-page: 1081 year: 1999 ident: bib1 article-title: Lung transplantation publication-title: N Engl J Med – volume: 82 start-page: 420 year: 1959 ident: bib17 article-title: Influence of glucose loading and of injected insulin on hepatic glucose output publication-title: Ann NY Acad Sci – volume: 100 start-page: 931 year: 1997 ident: bib10 article-title: Regulation of glucose homeostasis in humans with denervated livers publication-title: J Clin Invest – volume: 76 start-page: 541 year: 2002 ident: bib19 article-title: Resting energy expenditure in diabetic and non-diabetic patients with liver cirrhosis: relationship with insulin sensitivity, and effect of liver transplantation and of immunosuppressive therapy publication-title: Am J Clin Nutr – volume: 258 start-page: E948 year: 1990 ident: bib14 article-title: Effect of epinephrine upon amino acid and energy metabolism in humans publication-title: Am J Physiol – volume: 8 start-page: 421 year: 2005 ident: bib28 article-title: Changes in response to insulin and the effects of varying glucose tolerance on whole-body protein metabolism in patients with cystic fibrosis publication-title: Am J Clin Nutr – volume: 22 start-page: 845 year: 2003 ident: bib6 article-title: Indications, patient selection and timing of referral for lung transplantation publication-title: Eur Respir J – volume: 75 start-page: 2018 year: 2003 ident: bib22 article-title: Metabolic effects of a corticosteroid-free immunosuppressive regimen in recipients of pancreatic transplant publication-title: Transplantation – volume: 22 start-page: 37 year: 1996 ident: bib8 article-title: Impaired glucose tolerance in patients with chronic hypoxic pulmonary disease publication-title: Diabetes Metab – volume: 163 start-page: 358 year: 1987 ident: bib15 article-title: Glutamine and glutamate: automated quantification and isotopic enrichments by gas chromatography/mass spectrometry publication-title: Anal Biochem – volume: 323 start-page: 693 year: 1990 ident: bib27 article-title: Cyclosporine-induced sympathetic activation and hypertension after heart transplantation publication-title: N Engl J Med – volume: 25 start-page: 773 year: 2004 ident: bib4 article-title: Lung transplantation for interstitial lung disease publication-title: Clin Chest Med – volume: 31 start-page: 694 year: 2000 ident: bib23 article-title: Contribution of reduced insulin sensitivity and secretion to the pathogenesis of hepatogenous diabetes: effect of liver transplantation publication-title: Hepatology – volume: 23 start-page: 159 year: 2004 ident: bib2 article-title: Immunosuppressive therapy after human lung transplantation publication-title: Eur Respir J – volume: 268 start-page: E501 year: 1995 ident: bib13 article-title: Effect of cortisol on energy expenditure and amino acid metabolism in humans publication-title: Am J Physiol – volume: 24 start-page: 119 year: 2005 ident: bib3 article-title: Overview of tacrolimus-based immunosuppression after heart or lung transplantation publication-title: J Heart Lung Transplant – volume: 10 start-page: 191 year: 1998 ident: bib5 article-title: Lung transplantation for chronic obstructive pulmonary disease publication-title: Semin Thorac Cardiovasc Surg – volume: 52 start-page: 519 year: 1991 ident: bib26 article-title: In vivo effect of FK506 on human pancreatic islets publication-title: Transplantation – volume: 97 start-page: 2611 year: 1996 ident: bib21 article-title: Metabolic effects of successful intraportal islet transplantation in insulin-dependent diabetes mellitus publication-title: J Clin Invest – volume: 25 start-page: 530 year: 2002 ident: bib20 article-title: Glucose, fatty acids and leucine metabolism in heart transplanted patients publication-title: Diabetes Care – volume: 13 start-page: 213 year: 2002 ident: bib25 article-title: Glucose metabolism in the first 3 years after renal transplantation in patients receiving tacrolimus versus cyclosporine-based 5 immunosuppression publication-title: J Am Soc Nephrol – volume: 21 start-page: S5 year: 1998 ident: bib9 article-title: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus publication-title: Diabetes Care – volume: 41 start-page: 1632 year: 1992 ident: bib16 article-title: Lack of feedback inhibition of insulin secretion in denervated human pancreas publication-title: Diabetes – volume: 258 start-page: E948 year: 1990 ident: 10.1016/j.transproceed.2008.03.088_bib14 article-title: Effect of epinephrine upon amino acid and energy metabolism in humans publication-title: Am J Physiol – volume: 22 start-page: 37 year: 1996 ident: 10.1016/j.transproceed.2008.03.088_bib8 article-title: Impaired glucose tolerance in patients with chronic hypoxic pulmonary disease publication-title: Diabetes Metab – volume: 41 start-page: 1632 year: 1992 ident: 10.1016/j.transproceed.2008.03.088_bib16 article-title: Lack of feedback inhibition of insulin secretion in denervated human pancreas publication-title: Diabetes doi: 10.2337/diabetes.41.12.1632 – volume: 8 start-page: 421 year: 2005 ident: 10.1016/j.transproceed.2008.03.088_bib28 article-title: Changes in response to insulin and the effects of varying glucose tolerance on whole-body protein metabolism in patients with cystic fibrosis publication-title: Am J Clin Nutr doi: 10.1093/ajcn.81.2.421 – volume: 75 start-page: 2018 year: 2003 ident: 10.1016/j.transproceed.2008.03.088_bib22 article-title: Metabolic effects of a corticosteroid-free immunosuppressive regimen in recipients of pancreatic transplant publication-title: Transplantation doi: 10.1097/01.TP.0000065177.18714.2E – volume: 46 start-page: 1001 year: 1997 ident: 10.1016/j.transproceed.2008.03.088_bib29 article-title: Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study publication-title: Diabetes doi: 10.2337/diabetes.46.6.1001 – volume: 82 start-page: 420 year: 1959 ident: 10.1016/j.transproceed.2008.03.088_bib17 article-title: Influence of glucose loading and of injected insulin on hepatic glucose output publication-title: Ann NY Acad Sci doi: 10.1111/j.1749-6632.1959.tb44923.x – volume: 98 start-page: 7631 year: 1976 ident: 10.1016/j.transproceed.2008.03.088_bib12 article-title: Boroacetylation of carbohydrates: correlations between structure and mass spectral behavior in monoacetylhexose cyclic boronic esters publication-title: J Am Chem Soc doi: 10.1021/ja00440a030 – volume: 8340 start-page: 1081 year: 1999 ident: 10.1016/j.transproceed.2008.03.088_bib1 article-title: Lung transplantation publication-title: N Engl J Med doi: 10.1056/NEJM199904083401406 – volume: 163 start-page: 358 year: 1987 ident: 10.1016/j.transproceed.2008.03.088_bib15 article-title: Glutamine and glutamate: automated quantification and isotopic enrichments by gas chromatography/mass spectrometry publication-title: Anal Biochem doi: 10.1016/0003-2697(87)90236-3 – volume: 30 start-page: 1868 year: 1998 ident: 10.1016/j.transproceed.2008.03.088_bib24 article-title: Effect of liver transplantation in cirrhotic-diabetic patients publication-title: Transplant Proc doi: 10.1016/S0041-1345(98)00463-1 – volume: 13 start-page: 213 year: 2002 ident: 10.1016/j.transproceed.2008.03.088_bib25 article-title: Glucose metabolism in the first 3 years after renal transplantation in patients receiving tacrolimus versus cyclosporine-based 5 immunosuppression publication-title: J Am Soc Nephrol doi: 10.1681/ASN.V131213 – volume: 33 start-page: 549 year: 1990 ident: 10.1016/j.transproceed.2008.03.088_bib11 article-title: Reduction of insulin resistance by combined kidney–pancreas transplantation in type 1 (insulin-dependent) diabetic patients publication-title: Diabetologia doi: 10.1007/BF00404143 – volume: 24 start-page: 119 year: 2005 ident: 10.1016/j.transproceed.2008.03.088_bib3 article-title: Overview of tacrolimus-based immunosuppression after heart or lung transplantation publication-title: J Heart Lung Transplant doi: 10.1016/j.healun.2004.02.022 – volume: 76 start-page: 541 year: 2002 ident: 10.1016/j.transproceed.2008.03.088_bib19 article-title: Resting energy expenditure in diabetic and non-diabetic patients with liver cirrhosis: relationship with insulin sensitivity, and effect of liver transplantation and of immunosuppressive therapy publication-title: Am J Clin Nutr doi: 10.1093/ajcn/76.3.541 – volume: 21 start-page: S5 issue: suppl 1 year: 1998 ident: 10.1016/j.transproceed.2008.03.088_bib9 article-title: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus publication-title: Diabetes Care – volume: 21 start-page: 367 year: 2002 ident: 10.1016/j.transproceed.2008.03.088_bib7 article-title: Glucose metabolism in chronic lung disease publication-title: Clin Nutr doi: 10.1054/clnu.2002.0561 – volume: 22 start-page: 845 year: 2003 ident: 10.1016/j.transproceed.2008.03.088_bib6 article-title: Indications, patient selection and timing of referral for lung transplantation publication-title: Eur Respir J doi: 10.1183/09031936.03.00039003 – volume: 25 start-page: 773 year: 2004 ident: 10.1016/j.transproceed.2008.03.088_bib4 article-title: Lung transplantation for interstitial lung disease publication-title: Clin Chest Med doi: 10.1016/j.ccm.2004.04.008 – volume: 97 start-page: 2611 year: 1996 ident: 10.1016/j.transproceed.2008.03.088_bib21 article-title: Metabolic effects of successful intraportal islet transplantation in insulin-dependent diabetes mellitus publication-title: J Clin Invest doi: 10.1172/JCI118710 – volume: 100 start-page: 931 year: 1997 ident: 10.1016/j.transproceed.2008.03.088_bib10 article-title: Regulation of glucose homeostasis in humans with denervated livers publication-title: J Clin Invest doi: 10.1172/JCI119609 – volume: 31 start-page: 1105 year: 1982 ident: 10.1016/j.transproceed.2008.03.088_bib18 article-title: Relationship of plasma leucine and α-ketoisocaproate during a L-[1-13C]leucine infusion in man: a method for measuring human intracellular leucine tracer enrichment publication-title: Metabolism doi: 10.1016/0026-0495(82)90160-3 – volume: 23 start-page: 159 year: 2004 ident: 10.1016/j.transproceed.2008.03.088_bib2 article-title: Immunosuppressive therapy after human lung transplantation publication-title: Eur Respir J doi: 10.1183/09031936.03.00039203 – volume: 323 start-page: 693 year: 1990 ident: 10.1016/j.transproceed.2008.03.088_bib27 article-title: Cyclosporine-induced sympathetic activation and hypertension after heart transplantation publication-title: N Engl J Med doi: 10.1056/NEJM199009133231101 – volume: 10 start-page: 191 year: 1998 ident: 10.1016/j.transproceed.2008.03.088_bib5 article-title: Lung transplantation for chronic obstructive pulmonary disease publication-title: Semin Thorac Cardiovasc Surg doi: 10.1016/S1043-0679(98)70037-1 – volume: 31 start-page: 694 year: 2000 ident: 10.1016/j.transproceed.2008.03.088_bib23 article-title: Contribution of reduced insulin sensitivity and secretion to the pathogenesis of hepatogenous diabetes: effect of liver transplantation publication-title: Hepatology doi: 10.1002/hep.510310320 – volume: 25 start-page: 530 year: 2002 ident: 10.1016/j.transproceed.2008.03.088_bib20 article-title: Glucose, fatty acids and leucine metabolism in heart transplanted patients publication-title: Diabetes Care doi: 10.2337/diacare.25.3.530 – volume: 52 start-page: 519 year: 1991 ident: 10.1016/j.transproceed.2008.03.088_bib26 article-title: In vivo effect of FK506 on human pancreatic islets publication-title: Transplantation doi: 10.1097/00007890-199109000-00026 – volume: 268 start-page: E501 year: 1995 ident: 10.1016/j.transproceed.2008.03.088_bib13 article-title: Effect of cortisol on energy expenditure and amino acid metabolism in humans publication-title: Am J Physiol |
| SSID | ssj0004243 |
| Score | 1.8182487 |
| Snippet | This study examined the metabolic effects of lung transplantation in patients with end-stage respiratory failure on low dose of steroids for immunosuppressive... Abstract Background This study examined the metabolic effects of lung transplantation in patients with end-stage respiratory failure on low dose of steroids... |
| SourceID | proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1566 |
| SubjectTerms | Adult Aged Azathioprine - therapeutic use Biological and medical sciences Blood Glucose - metabolism Cyclosporine - therapeutic use Fatty Acids, Nonesterified - metabolism Female Fundamental and applied biological sciences. Psychology Fundamental immunology Glucocorticoids - therapeutic use Hormones - blood Humans Immunosuppressive Agents - therapeutic use Insulin Resistance Leucine - metabolism Lung Transplantation - physiology Male Medical sciences Middle Aged Prednisone - therapeutic use Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tacrolimus - therapeutic use Tissue, organ and graft immunology |
| Title | Glucose and Leucine Metabolism in Lung Tranplanted Patients on Low Dose of Steroids for Immunosuppressive Therapy |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0041134508003084 https://www.clinicalkey.es/playcontent/1-s2.0-S0041134508003084 https://dx.doi.org/10.1016/j.transproceed.2008.03.088 https://www.ncbi.nlm.nih.gov/pubmed/18589153 https://www.proquest.com/docview/69275619 |
| Volume | 40 |
| WOSCitedRecordID | wos000257695300074&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-2623 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0004243 issn: 0041-1345 databaseCode: AIEXJ dateStart: 19970201 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZ2AQkJIdgYlMvwA9rLliqJc7MQDwUNGNqmSStS36LEcaROJSlNs637W_xBjm9JS6lUhHixotM6cXy-nHNsnwtCb_3ET2jGPCtxoPEcmlopSSMrSHLqMBqmdpTJYhPh-Xk0GNCLjY2fJhbmehQWRXR7S8f_ldVAA2aL0Nm_YHdzUyDANTAdWmA7tGsx_rN2Qhc74qe8Fgfnh2d8CsweiYIYw-LwFD5wmdV8PBLzmok8_UMZ6VaKGr43YFWrHf5LmPRymMmUDYcnIpKkrOqxcp295sJbo8lIcDWn-uRtFbBa_dhux4N0BYL0IrjsNgc-dZ5r4nFD7PPJpL67k9SThnoGQK0rucV71l3YtYha7yq1lWbCaRa8PUXyL8shKr9klyuJHIXEcgMVlGxEtsrwpKHpz8lfsRqd0-WOr-q7LOkJtWVx1Z3KWVFToR1rSddWhQZ_y8N9KUYnBidsbGJH3ibadkOfgijd7p0cD7624biucdZUb2Ny3Uq3wlVPXGUXPRwnFXytuSqzsnodJO2h_mP0SC9kcE8B8Ana4MUO2u0VybT8PsMHWLoWyzObHXT_g7k6uFCp0mdHuN9G_lVHskOTRH22i35oGGOAMdYwxi2M8bDAAsZ4DsbYwBiX8GN5gwWMcZljA2MMMMZLMNYDmT1F3z4d9z9-sXR5EIvBomFqUQa2ZgL2Fcm9wHYyECuc8yCLaGgzWEjYNstSL2WBTxhNQdmAsuJ5mhKSprnnM7KHtoqy4M8RZl6UeYxw4rmJ5_lukgKOcvhz5OZAzjuIGubETOfOFyVcRrFxkryK5xmri7uSGBjbQaTpO1YZZNbq9c5gIDYx0qDVYwDwWr3DP_XmlZZTVezElRvb8RKoO-h901Pb4Mq2XvvJ-wuAbV7ZtT3qgjncQW8MgmPQZOJ4Mil4WVdxQEUpCod20DMF7Ha6IlH71Ccv_nFwL9GDVha9QlvTSc1fo3vsejqsJvtoMxxE-_pj_gWWhi3F |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Glucose+and+Leucine+Metabolism+in+Lung+Tranplanted+Patients+on+Low+Dose+of+Steroids+for+Immunosuppressive+Therapy&rft.jtitle=Transplantation+proceedings&rft.au=Benedini%2C+S.&rft.au=Ruffini%2C+E.&rft.au=Terruzzi%2C+I.&rft.au=Mancuso%2C+M.&rft.date=2008-06-01&rft.pub=Elsevier+Inc&rft.issn=0041-1345&rft.eissn=1873-2623&rft.volume=40&rft.issue=5&rft.spage=1566&rft.epage=1571&rft_id=info:doi/10.1016%2Fj.transproceed.2008.03.088&rft.externalDocID=S0041134508003084 |
| thumbnail_m | http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00411345%2FS0041134508X00065%2Fcov150h.gif |