FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. In addition to its remarkable pharmacologic actions, the physiological roles of FGF21 include the maintenance of energy homeos...

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Vydáno v:Diabetes & metabolism journal Ročník 38; číslo 4; s. 245 - 251
Hlavní autoři: Kim, Kook Hwan, Lee, Myung-Shik
Médium: Journal Article
Jazyk:angličtina
Vydáno: Korea (South) Korean Diabetes Association / Daehan Dangnyobyeong Hakoe 01.08.2014
Korean Diabetes Association
대한당뇨병학회
Témata:
Amino acids
Autophagy
Body fat
Diabetes
Diet
Fatty acids
Fibroblast growth factor 21
Glucagon
Glucose
Homeostasis
Human subjects
Insulin resistance
Lipids
Liver
Malnutrition
Metabolism
Mitochondria
Mitochondrial DNA
Musculoskeletal system
Obesity
Oxidation
Review
Starvation
Stress
Toxicity
내과학
Obesity
Insulin resistance
Fibroblast growth factor 21
Mitochondria
Stress
ISSN:2233-6079, 2233-6087
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Shrnutí:Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. In addition to its remarkable pharmacologic actions, the physiological roles of FGF21 include the maintenance of energy homeostasis in the body in conditions of metabolic or environmental stress. The expression of FGF21 is induced in multiple organs in response to diverse physiological or pathological stressors, such as starvation, nutrient excess, autophagy deficiency, mitochondrial stress, exercise, and cold exposure. Thus, the FGF21 induction caused by stress plays an important role in adaptive response to these stimuli. Here, we highlight our current understanding of the functional importance of the induction of FGF21 by diverse stressors as a feedback mechanism that prevents excessive stress.
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G704-SER000002700.2014.38.4.003
ISSN:2233-6079
2233-6087
DOI:10.4093/dmj.2014.38.4.245