GC-MS-based fecal metabolomics reveals gender-attributed fecal signatures in ankylosing spondylitis

Ankylosing spondylitis (AS) has different clinical features in males and females. Fecal metabolites play significant roles in AS disorders. This study aimed to reveal gender-attributed fecal signatures of AS. Fecal samples from 87 cross-sectional individuals (healthy controls: 20 males, 18 females;...

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Bibliographic Details
Published in:Scientific reports Vol. 9; no. 1; p. 3872
Main Authors: He, Zhixing, Wang, Mingzhu, Li, Haichang, Wen, Chengping
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 07.03.2019
Nature Publishing Group
Subjects:
631/1647/2196/1379
692/4023/1670/2766/1827
Acetic acid
Ankylosing spondylitis
Feces
Females
Gas chromatography
Gender
Humanities and Social Sciences
Inositol
Males
Mass spectroscopy
Metabolites
Metabolomics
multidisciplinary
Science
Science (multidisciplinary)
Spondylitis
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Ankylosing spondylitis (AS) has different clinical features in males and females. Fecal metabolites play significant roles in AS disorders. This study aimed to reveal gender-attributed fecal signatures of AS. Fecal samples from 87 cross-sectional individuals (healthy controls: 20 males, 18 females; AS patients: 26 males, 23 females) were analyzed by gas chromatography-mass spectroscopy (GC-MS). Partial least squares discriminant analysis (PLS-DA) was used to reveal differences in the fecal signatures of AS between males and females. Fecal signatures were defined by the significantly different fecal metabolites between AS patients and healthy individuals. Therefore, different fecal signatures of male and female AS patients were defined as gender-attributed fecal signatures. Male-specific fecal signatures in AS patients were steroid compounds, including cholestan-3-ol, tocopherol, stigmastan-3,5-diene, cholest-3-ene, cholest-4-en-6-one and 1-heptatriacotanol. Female-specific fecal signatures were ergost-5-en-3-ol, acetate and D-myo-Inositol. Gender-attributed fecal signatures of AS further reveal differences between males and females in terms of AS features.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-40351-w