Digital quantitative assessment of PD-L1 using digital spatial profiling

The assessment of programmed death 1 ligand 1 (PD-L1) expression by Immunohistochemistry (IHC) is the US Food and Drug Administration (FDA)-approved predictive marker to select responders to checkpoint blockade anti-PD-1/PD-L1 axis immunotherapies. Different PD-L1 immunohistochemistry (IHC) assays u...

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Vydané v:	Laboratory investigation Ročník 100; číslo 10; s. 1311 - 1317
Hlavní autori:	Gupta, Swati, Zugazagoitia, Jon, Martinez-Morilla, Sandra, Fuhrman, Kit, Rimm, David L.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Elsevier Inc 01.10.2020 Nature Publishing Group US Nature Publishing Group
Predmet:	13/105 13/51 631/61/32 692/53/2423 82/1 82/80 Antibodies Apoptosis Assaying B7-H1 Antigen - analysis B7-H1 Antigen - metabolism Biomarkers - analysis Biomarkers - metabolism Biotechnology Cell Line Correlation analysis Diagnostic systems FDA approval Fluorescence Humans Immune checkpoint Immune system Immunofluorescence Immunohistochemistry Immunohistochemistry - methods Immunohistochemistry - statistics & numerical data Immunotherapy L1 protein Laboratory Medicine Medicine Medicine & Public Health New technology Pathology PD-1 protein PD-L1 protein Protein Array Analysis - methods Protein Array Analysis - statistics & numerical data Proteins Reproducibility of Results Standardization Tissue Array Analysis - methods Tissue Array Analysis - statistics & numerical data Tissues Tumor cells
ISSN:	0023-6837, 1530-0307, 1530-0307
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