Fate of systemically and locally administered adipose‐derived mesenchymal stromal cells and their effect on wound healing
There is increasing interest in the use of adipose‐derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and effect of ASCs when administered either systemically or locally during wound repa...
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| Vydáno v: | Stem cells translational medicine Ročník 9; číslo 1; s. 131 - 144 |
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| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Hoboken, USA
John Wiley & Sons, Inc
01.01.2020
Oxford University Press |
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| ISSN: | 2157-6564, 2157-6580, 2157-6580 |
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| Abstract | There is increasing interest in the use of adipose‐derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and effect of ASCs when administered either systemically or locally during wound repair under physiological conditions. To determine the behavior of ASCs, a rat model with wounds on the dorsal aspect of the hind paws was used and two treatment modes were assessed: ASCs administered systemically into the tail vein or locally around the wound. ASCs were transduced to express both firefly luciferase (Fluc) and green fluorescent protein to enable tracking by bioluminescence imaging and immunohistological analysis. Systemically administered ASCs were detected in the lungs 3 hours after injection with a decrease in luminescent signal at 48 hours and signal disappearance from 72 hours. No ASCs were detected in the wound. Locally administered ASCs remained strongly detectable for 7 days at the injection site and became distributed within the wound bed as early as 24 hours post injection with a significant increase observed at 72 hours. Systemically administered ASCs were filtered out in the lungs, whereas ASCs administered locally remained and survived not only at the injection site but were also detected within the wound bed. Both treatments led to enhanced wound closure. It appears that systemically administered ASCs have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered ASCs enhanced wound repair as they became redistributed within the wound bed.
Adipose‐derived mesenchymal stromal cells were administered either systemically or locally in a rat model of wound repair under physiological conditions. It appears that systemically administered adipose‐derived mesenchymal stromal cells have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered adipose‐derived mesenchymal stromal cells enhanced wound repair as they became redistributed within the wound bed. |
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| AbstractList | There is increasing interest in the use of adipose-derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and effect of ASCs when administered either systemically or locally during wound repair under physiological conditions. To determine the behavior of ASCs, a rat model with wounds on the dorsal aspect of the hind paws was used and two treatment modes were assessed: ASCs administered systemically into the tail vein or locally around the wound. ASCs were transduced to express both firefly luciferase (Fluc) and green fluorescent protein to enable tracking by bioluminescence imaging and immunohistological analysis. Systemically administered ASCs were detected in the lungs 3 hours after injection with a decrease in luminescent signal at 48 hours and signal disappearance from 72 hours. No ASCs were detected in the wound. Locally administered ASCs remained strongly detectable for 7 days at the injection site and became distributed within the wound bed as early as 24 hours post injection with a significant increase observed at 72 hours. Systemically administered ASCs were filtered out in the lungs, whereas ASCs administered locally remained and survived not only at the injection site but were also detected within the wound bed. Both treatments led to enhanced wound closure. It appears that systemically administered ASCs have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered ASCs enhanced wound repair as they became redistributed within the wound bed. Abstract There is increasing interest in the use of adipose‐derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and effect of ASCs when administered either systemically or locally during wound repair under physiological conditions. To determine the behavior of ASCs, a rat model with wounds on the dorsal aspect of the hind paws was used and two treatment modes were assessed: ASCs administered systemically into the tail vein or locally around the wound. ASCs were transduced to express both firefly luciferase (Fluc) and green fluorescent protein to enable tracking by bioluminescence imaging and immunohistological analysis. Systemically administered ASCs were detected in the lungs 3 hours after injection with a decrease in luminescent signal at 48 hours and signal disappearance from 72 hours. No ASCs were detected in the wound. Locally administered ASCs remained strongly detectable for 7 days at the injection site and became distributed within the wound bed as early as 24 hours post injection with a significant increase observed at 72 hours. Systemically administered ASCs were filtered out in the lungs, whereas ASCs administered locally remained and survived not only at the injection site but were also detected within the wound bed. Both treatments led to enhanced wound closure. It appears that systemically administered ASCs have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered ASCs enhanced wound repair as they became redistributed within the wound bed. There is increasing interest in the use of adipose-derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and effect of ASCs when administered either systemically or locally during wound repair under physiological conditions. To determine the behavior of ASCs, a rat model with wounds on the dorsal aspect of the hind paws was used and two treatment modes were assessed: ASCs administered systemically into the tail vein or locally around the wound. ASCs were transduced to express both firefly luciferase (Fluc) and green fluorescent protein to enable tracking by bioluminescence imaging and immunohistological analysis. Systemically administered ASCs were detected in the lungs 3 hours after injection with a decrease in luminescent signal at 48 hours and signal disappearance from 72 hours. No ASCs were detected in the wound. Locally administered ASCs remained strongly detectable for 7 days at the injection site and became distributed within the wound bed as early as 24 hours post injection with a significant increase observed at 72 hours. Systemically administered ASCs were filtered out in the lungs, whereas ASCs administered locally remained and survived not only at the injection site but were also detected within the wound bed. Both treatments led to enhanced wound closure. It appears that systemically administered ASCs have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered ASCs enhanced wound repair as they became redistributed within the wound bed.There is increasing interest in the use of adipose-derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and effect of ASCs when administered either systemically or locally during wound repair under physiological conditions. To determine the behavior of ASCs, a rat model with wounds on the dorsal aspect of the hind paws was used and two treatment modes were assessed: ASCs administered systemically into the tail vein or locally around the wound. ASCs were transduced to express both firefly luciferase (Fluc) and green fluorescent protein to enable tracking by bioluminescence imaging and immunohistological analysis. Systemically administered ASCs were detected in the lungs 3 hours after injection with a decrease in luminescent signal at 48 hours and signal disappearance from 72 hours. No ASCs were detected in the wound. Locally administered ASCs remained strongly detectable for 7 days at the injection site and became distributed within the wound bed as early as 24 hours post injection with a significant increase observed at 72 hours. Systemically administered ASCs were filtered out in the lungs, whereas ASCs administered locally remained and survived not only at the injection site but were also detected within the wound bed. Both treatments led to enhanced wound closure. It appears that systemically administered ASCs have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered ASCs enhanced wound repair as they became redistributed within the wound bed. There is increasing interest in the use of adipose‐derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and effect of ASCs when administered either systemically or locally during wound repair under physiological conditions. To determine the behavior of ASCs, a rat model with wounds on the dorsal aspect of the hind paws was used and two treatment modes were assessed: ASCs administered systemically into the tail vein or locally around the wound. ASCs were transduced to express both firefly luciferase (Fluc) and green fluorescent protein to enable tracking by bioluminescence imaging and immunohistological analysis. Systemically administered ASCs were detected in the lungs 3 hours after injection with a decrease in luminescent signal at 48 hours and signal disappearance from 72 hours. No ASCs were detected in the wound. Locally administered ASCs remained strongly detectable for 7 days at the injection site and became distributed within the wound bed as early as 24 hours post injection with a significant increase observed at 72 hours. Systemically administered ASCs were filtered out in the lungs, whereas ASCs administered locally remained and survived not only at the injection site but were also detected within the wound bed. Both treatments led to enhanced wound closure. It appears that systemically administered ASCs have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered ASCs enhanced wound repair as they became redistributed within the wound bed. Adipose‐derived mesenchymal stromal cells were administered either systemically or locally in a rat model of wound repair under physiological conditions. It appears that systemically administered adipose‐derived mesenchymal stromal cells have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered adipose‐derived mesenchymal stromal cells enhanced wound repair as they became redistributed within the wound bed. There is increasing interest in the use of adipose‐derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and effect of ASCs when administered either systemically or locally during wound repair under physiological conditions. To determine the behavior of ASCs, a rat model with wounds on the dorsal aspect of the hind paws was used and two treatment modes were assessed: ASCs administered systemically into the tail vein or locally around the wound. ASCs were transduced to express both firefly luciferase (Fluc) and green fluorescent protein to enable tracking by bioluminescence imaging and immunohistological analysis. Systemically administered ASCs were detected in the lungs 3 hours after injection with a decrease in luminescent signal at 48 hours and signal disappearance from 72 hours. No ASCs were detected in the wound. Locally administered ASCs remained strongly detectable for 7 days at the injection site and became distributed within the wound bed as early as 24 hours post injection with a significant increase observed at 72 hours. Systemically administered ASCs were filtered out in the lungs, whereas ASCs administered locally remained and survived not only at the injection site but were also detected within the wound bed. Both treatments led to enhanced wound closure. It appears that systemically administered ASCs have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered ASCs enhanced wound repair as they became redistributed within the wound bed. Adipose‐derived mesenchymal stromal cells were administered either systemically or locally in a rat model of wound repair under physiological conditions. It appears that systemically administered adipose‐derived mesenchymal stromal cells have the potential to enhance wound repair distally from their site of entrapment in the lungs whereas locally administered adipose‐derived mesenchymal stromal cells enhanced wound repair as they became redistributed within the wound bed. |
| Author | Kallmeyer, Karlien Baquié, Mathurin Pepper, Michael S. Pittet‐Cuénod, Brigitte Krause, Karl‐Heinz Modarressi, Ali André‐Lévigne, Dominik |
| AuthorAffiliation | 1 Department of Plastic Reconstructive & Aesthetic Surgery, University Hospitals of Geneva, University of Geneva Geneva Switzerland 2 Institute for Cellular and Molecular Medicine (ICMM), Department of Immunology, and SAMRC Extramural Unit for Stem Cell Research and Therapy University of Pretoria Pretoria South Africa 5 Neurix SA Geneva Switzerland 3 Department of Pathology and Immunology University of Geneva Geneva Switzerland 4 Department of Human Genetics and Development University of Geneva Geneva Switzerland |
| AuthorAffiliation_xml | – name: 2 Institute for Cellular and Molecular Medicine (ICMM), Department of Immunology, and SAMRC Extramural Unit for Stem Cell Research and Therapy University of Pretoria Pretoria South Africa – name: 4 Department of Human Genetics and Development University of Geneva Geneva Switzerland – name: 5 Neurix SA Geneva Switzerland – name: 1 Department of Plastic Reconstructive & Aesthetic Surgery, University Hospitals of Geneva, University of Geneva Geneva Switzerland – name: 3 Department of Pathology and Immunology University of Geneva Geneva Switzerland |
| Author_xml | – sequence: 1 givenname: Karlien orcidid: 0000-0002-9181-694X surname: Kallmeyer fullname: Kallmeyer, Karlien email: karlienkallmeyer@gmail.com organization: University of Pretoria – sequence: 2 givenname: Dominik surname: André‐Lévigne fullname: André‐Lévigne, Dominik organization: Reconstructive & Aesthetic Surgery, University Hospitals of Geneva, University of Geneva – sequence: 3 givenname: Mathurin surname: Baquié fullname: Baquié, Mathurin organization: Neurix SA – sequence: 4 givenname: Karl‐Heinz surname: Krause fullname: Krause, Karl‐Heinz organization: University of Geneva – sequence: 5 givenname: Michael S. orcidid: 0000-0001-6406-2380 surname: Pepper fullname: Pepper, Michael S. organization: University of Geneva – sequence: 6 givenname: Brigitte surname: Pittet‐Cuénod fullname: Pittet‐Cuénod, Brigitte organization: Reconstructive & Aesthetic Surgery, University Hospitals of Geneva, University of Geneva – sequence: 7 givenname: Ali surname: Modarressi fullname: Modarressi, Ali email: ali.modarressi@hcuge.ch organization: Reconstructive & Aesthetic Surgery, University Hospitals of Geneva, University of Geneva |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31613054$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2019 The Authors. published by Wiley Periodicals, Inc. on behalf of AlphaMed Press 2019 The Authors. Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press. 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | in vivo imaging wound healing wound repair adipose-derived mesenchymal stromal cells bioluminescence imaging green fluorescent protein firefly luciferase |
| Language | English |
| License | Attribution http://creativecommons.org/licenses/by/4.0 2019 The Authors. Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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| Notes | Funding information Authored by a member of IFATS. SAMRC Extramural Unit for Stem Cell Research and Therapy; South African Medical Research Council University Flagship Program; Swiss National Science Foundation Project, Grant/Award Number: 310030_170132; Institute for Cellular and Molecular Medicine (ICMM); University of Pretoria Postgraduate Bursary Office; Ernst & Ethel Eriksen Trust; National Research Foundation, Grant/Award Number: 88799; Faculty of Medicine of the University of Geneva ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Funding information SAMRC Extramural Unit for Stem Cell Research and Therapy; South African Medical Research Council University Flagship Program; Swiss National Science Foundation Project, Grant/Award Number: 310030_170132; Institute for Cellular and Molecular Medicine (ICMM); University of Pretoria Postgraduate Bursary Office; Ernst & Ethel Eriksen Trust; National Research Foundation, Grant/Award Number: 88799; Faculty of Medicine of the University of Geneva |
| ORCID | 0000-0001-6406-2380 0000-0002-9181-694X |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fsctm.19-0091 |
| PMID | 31613054 |
| PQID | 2335629564 |
| PQPubID | 4370291 |
| PageCount | 14 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_a98f75522a6d4a80814f5f26eb0c62ac pubmedcentral_primary_oai_pubmedcentral_nih_gov_6954716 proquest_miscellaneous_2305799657 proquest_journals_2335629564 pubmed_primary_31613054 crossref_citationtrail_10_1002_sctm_19_0091 crossref_primary_10_1002_sctm_19_0091 wiley_primary_10_1002_sctm_19_0091_SCT312607 |
| PublicationCentury | 2000 |
| PublicationDate | January 2020 |
| PublicationDateYYYYMMDD | 2020-01-01 |
| PublicationDate_xml | – month: 01 year: 2020 text: January 2020 |
| PublicationDecade | 2020 |
| PublicationPlace | Hoboken, USA |
| PublicationPlace_xml | – name: Hoboken, USA – name: United States – name: Oxford |
| PublicationTitle | Stem cells translational medicine |
| PublicationTitleAlternate | Stem Cells Transl Med |
| PublicationYear | 2020 |
| Publisher | John Wiley & Sons, Inc Oxford University Press |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: Oxford University Press |
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| Snippet | There is increasing interest in the use of adipose‐derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly... There is increasing interest in the use of adipose-derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly... Abstract There is increasing interest in the use of adipose‐derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is... |
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| SubjectTerms | Adipose Tissue - cytology Adipose Tissue - metabolism adipose‐derived mesenchymal stromal cells Animals Bioluminescence bioluminescence imaging Disease Models, Animal firefly luciferase Flow cytometry Gene expression Glucose Green fluorescent protein Humans in vivo imaging Injection Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mesenchyme Rats Software Stromal cells Tissue‐specific Progenitor and Stem Cells Wound healing Wound Healing - drug effects wound repair |
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| Title | Fate of systemically and locally administered adipose‐derived mesenchymal stromal cells and their effect on wound healing |
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