YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

The Yes‐associated protein (YAP)/Hippo pathway has been implicated in tissue development, regeneration, and tumorigenesis. However, its role in cholangiocarcinoma (CC) is not established. We show that YAP activation is a common feature in CC patient biopsies and human CC cell lines. Using microarray...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 62; no. 5; pp. 1497 - 1510
Main Authors:	Marti, Patricia, Stein, Claudia, Blumer, Tanja, Abraham, Yann, Dill, Michael T., Pikiolek, Monika, Orsini, Vanessa, Jurisic, Giorgia, Megel, Philippe, Makowska, Zuzanna, Agarinis, Claudia, Tornillo, Luigi, Bouwmeester, Tewis, Ruffner, Heinz, Bauer, Andreas, Parker, Christian N., Schmelzle, Tobias, Terracciano, Luigi M., Heim, Markus H., Tchorz, Jan S.
Format:	Journal Article
Language:	English
Published:	United States Wolters Kluwer Health, Inc 01.11.2015
Subjects:	Angiogenesis Animals Apoptosis Bile Duct Neoplasms - blood supply Bile Duct Neoplasms - drug therapy Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic Cell Cycle Proteins Cell Proliferation Cholangiocarcinoma - blood supply Cholangiocarcinoma - drug therapy Cholangiocarcinoma - pathology Contractile Proteins - genetics DNA-Binding Proteins - physiology Drug Resistance, Neoplasm Female Gene Expression Regulation, Neoplastic Genes Glycoproteins - genetics Humans Intercellular Signaling Peptides and Proteins Mice Neovascularization, Pathologic - etiology Nuclear Proteins - physiology Oncogenes Transcription factors Transcription Factors - physiology
ISSN:	0270-9139, 1527-3350, 1527-3350
Online Access:	Get full text
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