Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy

An appropriate antibiotherapy is crucial for the safety and recovery of patients. Depending on the clinical conditions of patients, the required dose to effectively eradicate an infection may vary. An inadequate dosing not only reduces the efficacy of the antibiotic, but also promotes the emergence...

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Bibliographic Details
Published in:Scientific reports Vol. 7; no. 1; pp. 3127 - 10
Main Authors: Bruch, R., Chatelle, C., Kling, A., Rebmann, B., Wirth, S., Schumann, S., Weber, W., Dincer, C., Urban, G.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 09.06.2017
Nature Publishing Group
Nature Portfolio
Subjects:
101/1
101/62
142/126
631/1647/2196/2197
631/1647/277
631/61/350/877
96/95
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Antibiotics
beta-Lactams - administration & dosage
beta-Lactams - blood
beta-Lactams - pharmacokinetics
Blood levels
Cefazolin
Cefazolin - administration & dosage
Cefazolin - blood
Cefazolin - pharmacokinetics
Cefuroxime
Cefuroxime - administration & dosage
Cefuroxime - blood
Cefuroxime - pharmacokinetics
Cephalosporins
Drug Monitoring - instrumentation
Drug Monitoring - methods
Female
Humanities and Social Sciences
Humans
Male
Microfluidic Analytical Techniques
Microfluidics
multidisciplinary
Penicillin
Penicillin-binding protein
Pharmacokinetics
Piperacillin
Piperacillin - administration & dosage
Piperacillin - blood
Piperacillin - pharmacokinetics
Point-of-Care Testing
Precision Medicine
Science
Science (multidisciplinary)
Surgery
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:An appropriate antibiotherapy is crucial for the safety and recovery of patients. Depending on the clinical conditions of patients, the required dose to effectively eradicate an infection may vary. An inadequate dosing not only reduces the efficacy of the antibiotic, but also promotes the emergence of antimicrobial resistances. Therefore, a personalized therapy is of great interest for improved patients’ outcome and will reduce in long-term the prevalence of multidrug-resistances. In this context, on-site monitoring of the antibiotic blood concentration is fundamental to facilitate an individual adjustment of the antibiotherapy. Herein, we present a bioinspired approach for the bedside monitoring of free accessible ß-lactam antibiotics, including penicillins (piperacillin) and cephalosporins (cefuroxime and cefazolin) in untreated plasma samples. The introduced system combines a disposable microfluidic chip with a naturally occurring penicillin-binding protein, resulting in a high-performance platform, capable of gauging very low antibiotic concentrations (less than 6 ng ml −1 ) from only 1 µl of serum. The system’s applicability to a personalized antibiotherapy was successfully demonstrated by monitoring the pharmacokinetics of patients, treated with ß-lactam antibiotics, undergoing surgery.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-03338-z