Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy

An appropriate antibiotherapy is crucial for the safety and recovery of patients. Depending on the clinical conditions of patients, the required dose to effectively eradicate an infection may vary. An inadequate dosing not only reduces the efficacy of the antibiotic, but also promotes the emergence...

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Vydáno v:	Scientific reports Ročník 7; číslo 1; s. 3127 - 10
Hlavní autoři:	Bruch, R., Chatelle, C., Kling, A., Rebmann, B., Wirth, S., Schumann, S., Weber, W., Dincer, C., Urban, G.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 09.06.2017 Nature Publishing Group Nature Portfolio
Témata:	101/1 101/62 142/126 631/1647/2196/2197 631/1647/277 631/61/350/877 96/95 Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Antibiotics beta-Lactams - administration & dosage beta-Lactams - blood beta-Lactams - pharmacokinetics Blood levels Cefazolin Cefazolin - administration & dosage Cefazolin - blood Cefazolin - pharmacokinetics Cefuroxime Cefuroxime - administration & dosage Cefuroxime - blood Cefuroxime - pharmacokinetics Cephalosporins Drug Monitoring - instrumentation Drug Monitoring - methods Female Humanities and Social Sciences Humans Male Microfluidic Analytical Techniques Microfluidics multidisciplinary Penicillin Penicillin-binding protein Pharmacokinetics Piperacillin Piperacillin - administration & dosage Piperacillin - blood Piperacillin - pharmacokinetics Point-of-Care Testing Precision Medicine Science Science (multidisciplinary) Surgery
ISSN:	2045-2322, 2045-2322
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Shrnutí:	An appropriate antibiotherapy is crucial for the safety and recovery of patients. Depending on the clinical conditions of patients, the required dose to effectively eradicate an infection may vary. An inadequate dosing not only reduces the efficacy of the antibiotic, but also promotes the emergence of antimicrobial resistances. Therefore, a personalized therapy is of great interest for improved patients’ outcome and will reduce in long-term the prevalence of multidrug-resistances. In this context, on-site monitoring of the antibiotic blood concentration is fundamental to facilitate an individual adjustment of the antibiotherapy. Herein, we present a bioinspired approach for the bedside monitoring of free accessible ß-lactam antibiotics, including penicillins (piperacillin) and cephalosporins (cefuroxime and cefazolin) in untreated plasma samples. The introduced system combines a disposable microfluidic chip with a naturally occurring penicillin-binding protein, resulting in a high-performance platform, capable of gauging very low antibiotic concentrations (less than 6 ng ml −1 ) from only 1 µl of serum. The system’s applicability to a personalized antibiotherapy was successfully demonstrated by monitoring the pharmacokinetics of patients, treated with ß-lactam antibiotics, undergoing surgery.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-017-03338-z