Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila

Fecal transfer from healthy donors is being explored as a microbiome modality. MicroRNAs (miRNAs) have been found to affect the microbiome. Multiple sclerosis (MS) patients have been shown to have an altered gut microbiome. Here, we unexpectedly found that transfer of feces harvested at peak disease...

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Vydáno v:	Cell host & microbe Ročník 26; číslo 6; s. 779
Hlavní autoři:	Liu, Shirong, Rezende, Rafael M, Moreira, Thais G, Tankou, Stephanie K, Cox, Laura M, Wu, Meng, Song, Anya, Dhang, Fyonn H, Wei, Zhiyun, Costamagna, Gianluca, Weiner, Howard L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 11.12.2019
Témata:	Administration, Oral Animals Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Fecal Microbiota Transplantation Feces Gastrointestinal Microbiome - immunology Host Microbial Interactions Humans Lactase - metabolism Mice Mice, Inbred C57BL MicroRNAs - metabolism MicroRNAs - therapeutic use Multiple Sclerosis - drug therapy T-Lymphocytes, Regulatory - metabolism Verrucomicrobia - growth & development Verrucomicrobia - immunology Verrucomicrobia - metabolism autoimmune diseases fecal transplantation microvesicle experimental autoimmune encephalomyelitis multiple sclerosis microRNA Akkermansia muciniphila regulatory T cell microbiome host-microbe interaction
ISSN:	1934-6069, 1934-6069
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