Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

The discovery of brown adipose tissue (BAT) in adult humans presents a new therapeutic target for metabolic disease; however, little is known about the regulation of human BAT. Chronic glucocorticoid excess causes obesity in humans, and glucocorticoids suppress BAT activation in rodents. We tested w...

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Vydané v:	Cell metabolism Ročník 24; číslo 1; s. 130
Hlavní autori:	Ramage, Lynne E, Akyol, Murat, Fletcher, Alison M, Forsythe, John, Nixon, Mark, Carter, Roderick N, van Beek, Edwin J R, Morton, Nicholas M, Walker, Brian R, Stimson, Roland H
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 12.07.2016
Predmet:	Adipocytes - drug effects Adipocytes - metabolism Adipose Tissue, Brown - diagnostic imaging Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Animals Anthropometry Biopsy Cells, Cultured Cold Temperature Energy Metabolism - drug effects Fluorodeoxyglucose F18 - metabolism Gene Expression Regulation - drug effects Glucocorticoids - pharmacology Humans Male Mice RNA, Messenger - genetics RNA, Messenger - metabolism Skin Temperature - drug effects Species Specificity Uncoupling Protein 1 - genetics Uncoupling Protein 1 - metabolism Young Adult
ISSN:	1932-7420, 1932-7420
On-line prístup:	Zistit podrobnosti o prístupe
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