Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

The discovery of brown adipose tissue (BAT) in adult humans presents a new therapeutic target for metabolic disease; however, little is known about the regulation of human BAT. Chronic glucocorticoid excess causes obesity in humans, and glucocorticoids suppress BAT activation in rodents. We tested w...

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Bibliographic Details
Published in:	Cell metabolism Vol. 24; no. 1; p. 130
Main Authors:	Ramage, Lynne E, Akyol, Murat, Fletcher, Alison M, Forsythe, John, Nixon, Mark, Carter, Roderick N, van Beek, Edwin J R, Morton, Nicholas M, Walker, Brian R, Stimson, Roland H
Format:	Journal Article
Language:	English
Published:	United States 12.07.2016
Subjects:	Adipocytes - drug effects Adipocytes - metabolism Adipose Tissue, Brown - diagnostic imaging Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Animals Anthropometry Biopsy Cells, Cultured Cold Temperature Energy Metabolism - drug effects Fluorodeoxyglucose F18 - metabolism Gene Expression Regulation - drug effects Glucocorticoids - pharmacology Humans Male Mice RNA, Messenger - genetics RNA, Messenger - metabolism Skin Temperature - drug effects Species Specificity Uncoupling Protein 1 - genetics Uncoupling Protein 1 - metabolism Young Adult
ISSN:	1932-7420, 1932-7420
Online Access:	Get more information
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