Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence

Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is unknown. Here, we find that sedentary but not active humans display an age-related decline in the mitochondrial protein, optic atrophy 1 (OPA1), that is associated with muscle loss. In adult mice, acute, muscle-spe...

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Bibliographic Details
Published in:	Cell metabolism Vol. 25; no. 6; p. 1374
Main Authors:	Tezze, Caterina, Romanello, Vanina, Desbats, Maria Andrea, Fadini, Gian Paolo, Albiero, Mattia, Favaro, Giulia, Ciciliot, Stefano, Soriano, Maria Eugenia, Morbidoni, Valeria, Cerqua, Cristina, Loefler, Stefan, Kern, Helmut, Franceschi, Claudio, Salvioli, Stefano, Conte, Maria, Blaauw, Bert, Zampieri, Sandra, Salviati, Leonardo, Scorrano, Luca, Sandri, Marco
Format:	Journal Article
Language:	English
Published:	United States 06.06.2017
Subjects:	Aging - genetics Aging - metabolism Aging - pathology Animals Cellular Senescence - genetics Endoplasmic Reticulum Stress - genetics Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Inflammation - enzymology Inflammation - genetics Inflammation - pathology Mice Muscle, Skeletal - enzymology Muscle, Skeletal - pathology Muscular Atrophy - enzymology Muscular Atrophy - genetics Muscular Atrophy - pathology Organ Size Unfolded Protein Response - genetics FoxO Opa1 inflammation mitochondria muscle aging oxidative stress FGF21 sarcopenia
ISSN:	1932-7420, 1932-7420
Online Access:	Get more information
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