Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects

Abstract Background Metformin, the most widely administered diabetes drug, has been proposed as a candidate adjunctive host-directed therapy for tuberculosis, but little is known about its effects on human host responses to Mycobacterium tuberculosis. Methods We investigated in vitro and in vivo eff...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 220; no. 1; pp. 139 - 150
Main Authors:	Lachmandas, Ekta, Eckold, Clare, Böhme, Julia, Koeken, Valerie A C M, Marzuki, Mardiana Binte, Blok, Bastiaan, Arts, Rob J W, Chen, Jinmiao, Teng, Karen W W, Ratter, Jacqueline, Smolders, Elise J, Van den Heuvel, Corina, Stienstra, Rinke, Dockrell, Hazel M, Newell, Evan, Netea, Mihai G, Singhal, Amit, Cliff, Jacqueline M, Van Crevel, Reinout
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 05.06.2019
Subjects:	Cell Proliferation - drug effects Down-Regulation - drug effects Healthy Volunteers Host-Pathogen Interactions - drug effects Humans Hypoglycemic Agents - pharmacology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - microbiology Metformin - pharmacology Monocytes - drug effects Monocytes - metabolism Mycobacterium tuberculosis - pathogenicity Myeloid Cells - drug effects Myeloid Cells - metabolism Phagocytosis - drug effects Reactive Oxygen Species - metabolism Signal Transduction - drug effects Tuberculosis - metabolism Tuberculosis - microbiology Up-Regulation - drug effects gene transcription host-directed therapy Metformin antimycobacterial mechanisms tuberculosis
ISSN:	0022-1899, 1537-6613, 1537-6613
Online Access:	Get full text
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