Fasting blood glucose as a predictor of mortality: Lost in translation

Aging leads to profound changes in glucose homeostasis, weight, and adiposity, which are considered good predictors of health and survival in humans. Direct evidence that these age-associated metabolic alterations are recapitulated in animal models is lacking, impeding progress to develop and test i...

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Published in:	Cell metabolism Vol. 33; no. 11; p. 2189
Main Authors:	Palliyaguru, Dushani L, Shiroma, Eric J, Nam, John K, Duregon, Eleonora, Vieira Ligo Teixeira, Camila, Price, Nathan L, Bernier, Michel, Camandola, Simonetta, Vaughan, Kelli L, Colman, Ricki J, Deighan, Andrew, Korstanje, Ron, Peters, Luanne L, Dickinson, Stephanie L, Ejima, Keisuke, Simonsick, Eleanor M, Launer, Lenore J, Chia, Chee W, Egan, Josephine, Allison, David B, Churchill, Gary A, Anderson, Rozalyn M, Ferrucci, Luigi, Mattison, Julie A, de Cabo, Rafael
Format:	Journal Article
Language:	English
Published:	United States 02.11.2021
Subjects:	Adiposity Animals Blood Glucose - metabolism Fasting Longevity Mice Obesity - metabolism predictors fasting blood glucose mortality metabolism nonhuman primates humans mice
ISSN:	1932-7420, 1932-7420
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Abstract	Aging leads to profound changes in glucose homeostasis, weight, and adiposity, which are considered good predictors of health and survival in humans. Direct evidence that these age-associated metabolic alterations are recapitulated in animal models is lacking, impeding progress to develop and test interventions that delay the onset of metabolic dysfunction and promote healthy aging and longevity. We compared longitudinal trajectories, rates of change, and mortality risks of fasting blood glucose, body weight, and fat mass in mice, nonhuman primates, and humans throughout their lifespans and found similar trajectories of body weight and fat in the three species. In contrast, fasting blood glucose decreased late in life in mice but increased over the lifespan of nonhuman primates and humans. Higher glucose was associated with lower mortality in mice but higher mortality in nonhuman primates and humans, providing a cautionary tale for translating age-associated metabolic changes from mice to humans.
AbstractList	Aging leads to profound changes in glucose homeostasis, weight, and adiposity, which are considered good predictors of health and survival in humans. Direct evidence that these age-associated metabolic alterations are recapitulated in animal models is lacking, impeding progress to develop and test interventions that delay the onset of metabolic dysfunction and promote healthy aging and longevity. We compared longitudinal trajectories, rates of change, and mortality risks of fasting blood glucose, body weight, and fat mass in mice, nonhuman primates, and humans throughout their lifespans and found similar trajectories of body weight and fat in the three species. In contrast, fasting blood glucose decreased late in life in mice but increased over the lifespan of nonhuman primates and humans. Higher glucose was associated with lower mortality in mice but higher mortality in nonhuman primates and humans, providing a cautionary tale for translating age-associated metabolic changes from mice to humans. Aging leads to profound changes in glucose homeostasis, weight, and adiposity, which are considered good predictors of health and survival in humans. Direct evidence that these age-associated metabolic alterations are recapitulated in animal models is lacking, impeding progress to develop and test interventions that delay the onset of metabolic dysfunction and promote healthy aging and longevity. We compared longitudinal trajectories, rates of change, and mortality risks of fasting blood glucose, body weight, and fat mass in mice, nonhuman primates, and humans throughout their lifespans and found similar trajectories of body weight and fat in the three species. In contrast, fasting blood glucose decreased late in life in mice but increased over the lifespan of nonhuman primates and humans. Higher glucose was associated with lower mortality in mice but higher mortality in nonhuman primates and humans, providing a cautionary tale for translating age-associated metabolic changes from mice to humans.Aging leads to profound changes in glucose homeostasis, weight, and adiposity, which are considered good predictors of health and survival in humans. Direct evidence that these age-associated metabolic alterations are recapitulated in animal models is lacking, impeding progress to develop and test interventions that delay the onset of metabolic dysfunction and promote healthy aging and longevity. We compared longitudinal trajectories, rates of change, and mortality risks of fasting blood glucose, body weight, and fat mass in mice, nonhuman primates, and humans throughout their lifespans and found similar trajectories of body weight and fat in the three species. In contrast, fasting blood glucose decreased late in life in mice but increased over the lifespan of nonhuman primates and humans. Higher glucose was associated with lower mortality in mice but higher mortality in nonhuman primates and humans, providing a cautionary tale for translating age-associated metabolic changes from mice to humans.
Author	Palliyaguru, Dushani L Chia, Chee W Anderson, Rozalyn M Peters, Luanne L Bernier, Michel Mattison, Julie A Allison, David B Dickinson, Stephanie L Shiroma, Eric J Ejima, Keisuke de Cabo, Rafael Duregon, Eleonora Camandola, Simonetta Ferrucci, Luigi Price, Nathan L Korstanje, Ron Churchill, Gary A Vieira Ligo Teixeira, Camila Egan, Josephine Launer, Lenore J Nam, John K Deighan, Andrew Colman, Ricki J Simonsick, Eleanor M Vaughan, Kelli L
Author_xml	– sequence: 1 givenname: Dushani L surname: Palliyaguru fullname: Palliyaguru, Dushani L organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 2 givenname: Eric J surname: Shiroma fullname: Shiroma, Eric J organization: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 3 givenname: John K surname: Nam fullname: Nam, John K organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 4 givenname: Eleonora surname: Duregon fullname: Duregon, Eleonora organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 5 givenname: Camila surname: Vieira Ligo Teixeira fullname: Vieira Ligo Teixeira, Camila organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 6 givenname: Nathan L surname: Price fullname: Price, Nathan L organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA; Vascular Biology and Therapeutics Program, Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA – sequence: 7 givenname: Michel surname: Bernier fullname: Bernier, Michel organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 8 givenname: Simonetta surname: Camandola fullname: Camandola, Simonetta organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 9 givenname: Kelli L surname: Vaughan fullname: Vaughan, Kelli L organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 10 givenname: Ricki J surname: Colman fullname: Colman, Ricki J organization: Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA – sequence: 11 givenname: Andrew surname: Deighan fullname: Deighan, Andrew organization: The Jackson Laboratory, Bar Harbor, ME 04609, USA – sequence: 12 givenname: Ron surname: Korstanje fullname: Korstanje, Ron organization: The Jackson Laboratory, Bar Harbor, ME 04609, USA – sequence: 13 givenname: Luanne L surname: Peters fullname: Peters, Luanne L organization: The Jackson Laboratory, Bar Harbor, ME 04609, USA – sequence: 14 givenname: Stephanie L surname: Dickinson fullname: Dickinson, Stephanie L organization: School of Public Health, Indiana University, Bloomington, IN 47405, USA – sequence: 15 givenname: Keisuke surname: Ejima fullname: Ejima, Keisuke organization: School of Public Health, Indiana University, Bloomington, IN 47405, USA – sequence: 16 givenname: Eleanor M surname: Simonsick fullname: Simonsick, Eleanor M organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 17 givenname: Lenore J surname: Launer fullname: Launer, Lenore J organization: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 18 givenname: Chee W surname: Chia fullname: Chia, Chee W organization: Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 19 givenname: Josephine surname: Egan fullname: Egan, Josephine organization: Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 20 givenname: David B surname: Allison fullname: Allison, David B organization: School of Public Health, Indiana University, Bloomington, IN 47405, USA – sequence: 21 givenname: Gary A surname: Churchill fullname: Churchill, Gary A organization: The Jackson Laboratory, Bar Harbor, ME 04609, USA – sequence: 22 givenname: Rozalyn M surname: Anderson fullname: Anderson, Rozalyn M organization: Department of Medicine, University of Wisconsin-Madison and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA – sequence: 23 givenname: Luigi surname: Ferrucci fullname: Ferrucci, Luigi organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 24 givenname: Julie A surname: Mattison fullname: Mattison, Julie A organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA – sequence: 25 givenname: Rafael surname: de Cabo fullname: de Cabo, Rafael email: decabora@grc.nia.nih.gov organization: Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA. Electronic address: decabora@grc.nia.nih.gov
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Title	Fasting blood glucose as a predictor of mortality: Lost in translation
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