Protein identification strategies in MALDI imaging mass spectrometry: a brief review
[Display omitted] Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful technology used to investigate the spatial distributions of thousands of molecules throughout a tissue section from a single experiment. As proteins represent an important group of fun...
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| Vydáno v: | Current opinion in chemical biology Ročník 48; s. 64 - 72 |
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| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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England
Elsevier Ltd
01.02.2019
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| ISSN: | 1367-5931, 1879-0402, 1879-0402 |
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| Abstract | [Display omitted]
Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful technology used to investigate the spatial distributions of thousands of molecules throughout a tissue section from a single experiment. As proteins represent an important group of functional molecules in tissue and cells, the imaging of proteins has been an important point of focus in the development of IMS technologies and methods. Protein identification is crucial for the biological contextualization of molecular imaging data. However, gas-phase fragmentation efficiency of MALDI generated proteins presents significant challenges, making protein identification directly from tissue difficult. This review highlights methods and technologies specifically related to protein identification that have been developed to overcome these challenges in MALDI IMS experiments. |
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| AbstractList | Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful technology used to investigate the spatial distributions of thousands of molecules throughout a tissue section from a single experiment. As proteins represent an important group of functional molecules in tissue and cells, the imaging of proteins has been an important point of focus in the development of IMS technologies and methods. Protein identification is crucial for the biological contextualization of molecular imaging data. However, gas-phase fragmentation efficiency of MALDI generated proteins presents significant challenges, making protein identification directly from tissue difficult. This review highlights methods and technologies specifically related to protein identification that have been developed to overcome these challenges in MALDI IMS experiments. [Display omitted] Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful technology used to investigate the spatial distributions of thousands of molecules throughout a tissue section from a single experiment. As proteins represent an important group of functional molecules in tissue and cells, the imaging of proteins has been an important point of focus in the development of IMS technologies and methods. Protein identification is crucial for the biological contextualization of molecular imaging data. However, gas-phase fragmentation efficiency of MALDI generated proteins presents significant challenges, making protein identification directly from tissue difficult. This review highlights methods and technologies specifically related to protein identification that have been developed to overcome these challenges in MALDI IMS experiments. Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful technology used to investigate the spatial distributions of thousands of molecules throughout a tissue section from a single experiment. As proteins represent an important group of functional molecules in tissue and cells, the imaging of proteins has been an important point of focus in the development of IMS technologies and methods. Protein identification is crucial for the biological contextualization of molecular imaging data. However, gas-phase fragmentation efficiency of MALDI generated proteins presents significant challenges, making protein identification directly from tissue difficult. This review highlights methods and technologies specifically related to protein identification that have been developed to overcome these challenges in MALDI IMS experiments.Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful technology used to investigate the spatial distributions of thousands of molecules throughout a tissue section from a single experiment. As proteins represent an important group of functional molecules in tissue and cells, the imaging of proteins has been an important point of focus in the development of IMS technologies and methods. Protein identification is crucial for the biological contextualization of molecular imaging data. However, gas-phase fragmentation efficiency of MALDI generated proteins presents significant challenges, making protein identification directly from tissue difficult. This review highlights methods and technologies specifically related to protein identification that have been developed to overcome these challenges in MALDI IMS experiments. |
| Author | Caprioli, Richard M Ryan, Daniel J Spraggins, Jeffrey M |
| AuthorAffiliation | 2 Mass Spectrometry Research Center, Vanderbilt University, 465 21 st Ave S #9160, Nashville, TN 37235, USA 1 Department of Chemistry, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, TN 37235, USA 4 Department of Pharmacology, Vanderbilt University, 442 Robinson Research Building, 2220 Pierce Avenue, Nashville, TN 37232, USA 3 Department of Biochemistry, Vanderbilt University, 607 Light Hall, Nashville, TN 37205, USA 5 Department of Medicine, Vanderbilt University, 465 21 st Ave #9160, Nashville, TN 37235, USA |
| AuthorAffiliation_xml | – name: 4 Department of Pharmacology, Vanderbilt University, 442 Robinson Research Building, 2220 Pierce Avenue, Nashville, TN 37232, USA – name: 5 Department of Medicine, Vanderbilt University, 465 21 st Ave #9160, Nashville, TN 37235, USA – name: 3 Department of Biochemistry, Vanderbilt University, 607 Light Hall, Nashville, TN 37205, USA – name: 2 Mass Spectrometry Research Center, Vanderbilt University, 465 21 st Ave S #9160, Nashville, TN 37235, USA – name: 1 Department of Chemistry, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, TN 37235, USA |
| Author_xml | – sequence: 1 givenname: Daniel J orcidid: 0000-0001-8201-1472 surname: Ryan fullname: Ryan, Daniel J organization: Department of Chemistry, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, TN 37235, USA – sequence: 2 givenname: Jeffrey M surname: Spraggins fullname: Spraggins, Jeffrey M organization: Department of Chemistry, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, TN 37235, USA – sequence: 3 givenname: Richard M surname: Caprioli fullname: Caprioli, Richard M email: richard.m.caprioli@Vanderbilt.Edu organization: Department of Chemistry, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, TN 37235, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30476689$$D View this record in MEDLINE/PubMed |
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Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful technology used to investigate the spatial... Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful technology used to investigate the spatial distributions of... |
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| SubjectTerms | Animals Equipment Design Humans Molecular Imaging - instrumentation Molecular Imaging - methods Proteins - analysis Proteins - isolation & purification Specimen Handling - instrumentation Specimen Handling - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Workflow |
| Title | Protein identification strategies in MALDI imaging mass spectrometry: a brief review |
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